Growth inhibition of Francisella tularensis live vaccine strain by IFN- gamma-activated macrophages is mediated by reactive nitrogen intermediates derived from L-arginine metabolism

We have examined the abilities of the recombinant murine lymphokines IFN-gamma, granulocyte-macrophage (GM)-CSF, and IL-4 to stimulate the in vitro antimicrobial activity of macrophages against the live vaccine strain (LVS) of Francisella tularensis. Resident peritoneal macrophages from C57BL/6 stra...

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