The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice
Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (alpha2-alpha10, beta2-beta4), are expressed in autonomic ganglia, playing a central role in autonomic transmission. The repertoire of nicotinic subunits in autonomic ganglia includes alpha3, alpha5, alpha7, beta2 and beta4...
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| Veröffentlicht in: | Progress in neurobiology 2002-12, Vol.68 (5), p.341-360 |
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| creator | Wang, Ningshan Orr-Urtreger, Avi Korczyn, Amos D |
| description | Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (alpha2-alpha10, beta2-beta4), are expressed in autonomic ganglia, playing a central role in autonomic transmission. The repertoire of nicotinic subunits in autonomic ganglia includes alpha3, alpha5, alpha7, beta2 and beta4 subunits. In the last 10 years, heterologous expression studies have revealed much about the nature of neuronal nAChRs. However, there is only limited understanding of subunit actions in autonomic system. Functional deletions of subunit by gene knockout in animals could overcome these limitations. We review recent studies on nAChRs on autonomic ganglia for physiological and pharmacological properties and potential locations of the subunits. |
| doi_str_mv | 10.1016/s0301-0082(02)00106-5 |
| format | Article |
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We review recent studies on nAChRs on autonomic ganglia for physiological and pharmacological properties and potential locations of the subunits.</description><subject>Animals</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Ganglia, Autonomic - physiology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Models, Animal</subject><subject>Protein Subunits - genetics</subject><subject>Protein Subunits - physiology</subject><subject>Receptors, Nicotinic - genetics</subject><subject>Receptors, Nicotinic - physiology</subject><subject>Synaptic Transmission - physiology</subject><subject>Up-Regulation - physiology</subject><issn>0301-0082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9LxDAQxXNQ3HX1Iyg5iR6qk6RJW2-y-A8ED67nkE2nWjdN1qQ9-O1tcdGjMMzA8Hsz8B4hJwwuGTB1lUAAywBKfg78AoCByuQemf-uZ-QwpQ8AUALEAZkxLgXjIp-TsHpHGoNDGhrqcYjBG0d9a0Pfjp0ai_2Xs-_BtX4E0eK2D5GmYT34tk-09dQMffChG-E3499ca66pw5SCT7SJoaMbH-wmDD0dETwi-41xCY93c0Fe725Xy4fs6fn-cXnzlNkceJ-xYi2rRpWqKkqjuKyxtqwGhjVYqAqjhFS5VKVBrkpRWTDQSODMNqrCoirFgpz93N3G8Dlg6nXXJovOGY9hSLrgJc9Vzv8FWTlSwKeL8ge0MaQUsdHb2HYmfmkGeopBv0x-68lvDWNNMWg56k53D4Z1h_WfapeB-Ab234Y9</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Wang, Ningshan</creator><creator>Orr-Urtreger, Avi</creator><creator>Korczyn, Amos D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice</title><author>Wang, Ningshan ; Orr-Urtreger, Avi ; Korczyn, Amos D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-17b59f686978a625dedc1d01ed0c097a63564568ae26839c0a0f5021cf69e7983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>Ganglia, Autonomic - physiology</topic><topic>Gene Expression Regulation - physiology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Models, Animal</topic><topic>Protein Subunits - genetics</topic><topic>Protein Subunits - physiology</topic><topic>Receptors, Nicotinic - genetics</topic><topic>Receptors, Nicotinic - physiology</topic><topic>Synaptic Transmission - physiology</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Ningshan</creatorcontrib><creatorcontrib>Orr-Urtreger, Avi</creatorcontrib><creatorcontrib>Korczyn, Amos D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Ningshan</au><au>Orr-Urtreger, Avi</au><au>Korczyn, Amos D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice</atitle><jtitle>Progress in neurobiology</jtitle><addtitle>Prog Neurobiol</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>68</volume><issue>5</issue><spage>341</spage><epage>360</epage><pages>341-360</pages><issn>0301-0082</issn><abstract>Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (alpha2-alpha10, beta2-beta4), are expressed in autonomic ganglia, playing a central role in autonomic transmission. 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| subjects | Animals Excitatory Postsynaptic Potentials - physiology Ganglia, Autonomic - physiology Gene Expression Regulation - physiology Mice Mice, Knockout Models, Animal Protein Subunits - genetics Protein Subunits - physiology Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology Synaptic Transmission - physiology Up-Regulation - physiology |
| title | The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice |
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