Kinetics of anti-CD4-induced T helper cell depletion and inhibition of function. Activation of T cells by the CD3 pathway inhibits anti-CD4- mediated T cell elimination and down-regulation of cell surface CD4

In vivo treatment with anti-CD4 antibody profoundly suppresses a number of T cell-dependent responses and is clinically useful in the treatment of certain mouse models of autoimmune disease. Treatment with anti-CD4 antibody will inactivate and can deplete CD4 T cells, but the mechanisms responsible...

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Veröffentlicht in:	The Journal of immunology (1950) 1992-03, Vol.148 (6), p.1613-1619
Hauptverfasser:	Jamali, I, Field, EH, Fleming, A, Cowdery, JS
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Antibody Reactions Antigens, Differentiation, T-Lymphocyte - physiology CD3 Complex CD4 Antigens - immunology CD4 Antigens - metabolism CD4-Positive T-Lymphocytes - immunology Down-Regulation Isoantibodies - immunology Lymphocyte Activation Lymphocyte Depletion Macrophages - immunology Receptors, Antigen, T-Cell - physiology Spleen - cytology T-Lymphocytes, Helper-Inducer - immunology Time Factors
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