Basic calcium phosphate crystals stimulate cell proliferation and collagenase message accumulation in cultured adult articular chondrocytes

Objective. To investigate BCP (basic calcium phosphate) crystal—stimulated mitogenesis and collagenase gene transcription in primary cultures of porcine chondrocytes. Methods. The role of protein kinases in BCP crystal—stimulated DNA synthesis was investigated using thymidine incorporation, kinase i...

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Veröffentlicht in:	Arthritis and rheumatism 1992-03, Vol.35 (3), p.343-350
Hauptverfasser:	Mitchell, Peter G., Struve, Janine A., Mccarthy, Geraldine M., Cheung, Herman S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium Phosphates - pharmacology Cartilage, Articular - cytology Cell cycle, cell proliferation Cell Division - drug effects Cell physiology Crystallization DNA - biosynthesis Fundamental and applied biological sciences. Psychology Humans Membrane Proteins - metabolism Microbial Collagenase - genetics Molecular and cellular biology Protein Kinase C - pharmacology Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-jun - genetics RNA, Messenger Transcription, Genetic
Online-Zugang:	Volltext
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