Endogenous interferon and triglyceride concentrations to assess response to zidovudine in AIDS and advanced AIDS-related complex

To improve evaluation of new antiretroviral drugs in the acquired immunodeficiency syndrome (AIDS), sensitive biological markers that accurately predict response to treatment are needed. Two possible markers are endogenous interferon (E-IFN), which is a cytokine involved in the pathophysiology of AI...

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Veröffentlicht in:	The Lancet (British edition) 1992-02, Vol.339 (8791), p.453-456
Hauptverfasser:	Mildvan, D, Wilets, I, Machado, S.G, Grossberg, S.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - mortality Adult AIDS AIDS-related complex AIDS-Related Complex - blood AIDS-Related Complex - drug therapy AIDS-Related Complex - mortality AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiviral agents Biological and medical sciences Biomarkers Biomarkers - blood Body Mass Index CD4 antigen CD4-Positive T-Lymphocytes Cytokines Drugs Health care HIV HIV Core Protein p24 - analysis Human immunodeficiency virus Humans Immunodeficiency Interferon Interferons - blood Leukocyte Count Medical research Medical sciences Middle Aged Patients Pharmacology. Drug treatments Proportional Hazards Models Retrospective Studies Survival Survival Analysis Survival Rate Triglycerides Triglycerides - blood Viruses Zidovudine Zidovudine - therapeutic use
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