Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura
Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-u...
Gespeichert in:
| Veröffentlicht in: | Internal Medicine 2002, Vol.41(12), pp.1199-1203 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1203 |
|---|---|
| container_issue | 12 |
| container_start_page | 1199 |
| container_title | Internal Medicine |
| container_volume | 41 |
| creator | KAMEI, Nozomu YAMANE, Kiminori YAMASHITA, Yasuyo NAKANISHI, Shuhei WATANABE, Hiroshi FUJIKAWA, Rumi HIYAMA, Keiko ISHIOKA, Shinichi MENDOZA, Giro KOHNO, Nobuoki |
| description | Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose γ-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases. (Internal Medicine 41: 1199-1203, 2002) |
| doi_str_mv | 10.2169/internalmedicine.41.1199 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72820220</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72820220</sourcerecordid><originalsourceid>FETCH-LOGICAL-c616t-84d38e0141d0781d462ccc04a045e45611ab68e6a029ca55b408a5751db046b33</originalsourceid><addsrcrecordid>eNplkcFu1DAQhi0EokvhFZAvwCmL7ThOcqy6pVRUaqUtZ2vizLauEjvYzkp5AN6bpLu0Elz-Ocw3M7_mJ4RythZc1V-tSxgcdD221liHa8nXnNf1K7LiuayzUuTFa7JiNa8yMcsJeRfjI2N5VdbiLTnhohB83rQiv89cstmPkS618e2U3fpok90j3ZoOg28x9JBtFk2-n56akd7sMXQw0O3k2uB7pBvcY-cH6-7pZYA9xi90YyNCRAqupVd9Pzqkdw8z3HgzJT-gs4bejmEYA7wnb3bQRfxwrKfk57eLu_Pv2fXN5dX52XVmFFcpq2SbV8i45C0rK95KJYwxTAKTBcpCcQ6NqlABE7WBomgkq6AoC942TKomz0_J58PeIfhfI8akexsNdh049GPUpagEE4LNYHUATfAxBtzpIdgewqQ500sE-t8ItOR6iWAe_Xi8MTZz82Xw-PMZ-HQEIBrodgGcsfGFk4XMS7WY3R64x5jgHp8BCMnO0fznYD4unlz81cXOM20eIGh0-R8dR7Tr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72820220</pqid></control><display><type>article</type><title>Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>KAMEI, Nozomu ; YAMANE, Kiminori ; YAMASHITA, Yasuyo ; NAKANISHI, Shuhei ; WATANABE, Hiroshi ; FUJIKAWA, Rumi ; HIYAMA, Keiko ; ISHIOKA, Shinichi ; MENDOZA, Giro ; KOHNO, Nobuoki</creator><creatorcontrib>KAMEI, Nozomu ; YAMANE, Kiminori ; YAMASHITA, Yasuyo ; NAKANISHI, Shuhei ; WATANABE, Hiroshi ; FUJIKAWA, Rumi ; HIYAMA, Keiko ; ISHIOKA, Shinichi ; MENDOZA, Giro ; KOHNO, Nobuoki</creatorcontrib><description>Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose γ-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases. (Internal Medicine 41: 1199-1203, 2002)</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.41.1199</identifier><identifier>PMID: 12521216</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Anti-Inflammatory Agents - therapeutic use ; anti-thyroid drug ; Antigens, Nuclear - immunology ; Antithyroid Agents - therapeutic use ; Autoantibodies - blood ; Biological and medical sciences ; Dermatomyositis - complications ; Dermatomyositis - drug therapy ; Dermatomyositis - immunology ; DNA Helicases ; DNA-Binding Proteins - immunology ; Endocrinopathies ; Female ; Graves Disease - complications ; Graves Disease - drug therapy ; Graves Disease - immunology ; Humans ; Ku Autoantigen ; Medical sciences ; Methimazole - therapeutic use ; natural killer Tcell ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Platelet Transfusion ; Propylthiouracil - therapeutic use ; Purpura, Thrombocytopenic, Idiopathic - complications ; Purpura, Thrombocytopenic, Idiopathic - immunology ; Purpura, Thrombocytopenic, Idiopathic - therapy ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - drug therapy ; Scleroderma, Systemic - immunology ; Steroids ; thrombocytopenia ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Internal Medicine, 2002, Vol.41(12), pp.1199-1203</ispartof><rights>The Japanese Society of Internal Medicine</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-84d38e0141d0781d462ccc04a045e45611ab68e6a029ca55b408a5751db046b33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14543763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12521216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAMEI, Nozomu</creatorcontrib><creatorcontrib>YAMANE, Kiminori</creatorcontrib><creatorcontrib>YAMASHITA, Yasuyo</creatorcontrib><creatorcontrib>NAKANISHI, Shuhei</creatorcontrib><creatorcontrib>WATANABE, Hiroshi</creatorcontrib><creatorcontrib>FUJIKAWA, Rumi</creatorcontrib><creatorcontrib>HIYAMA, Keiko</creatorcontrib><creatorcontrib>ISHIOKA, Shinichi</creatorcontrib><creatorcontrib>MENDOZA, Giro</creatorcontrib><creatorcontrib>KOHNO, Nobuoki</creatorcontrib><title>Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose γ-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases. (Internal Medicine 41: 1199-1203, 2002)</description><subject>Adult</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>anti-thyroid drug</subject><subject>Antigens, Nuclear - immunology</subject><subject>Antithyroid Agents - therapeutic use</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Dermatomyositis - complications</subject><subject>Dermatomyositis - drug therapy</subject><subject>Dermatomyositis - immunology</subject><subject>DNA Helicases</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Graves Disease - complications</subject><subject>Graves Disease - drug therapy</subject><subject>Graves Disease - immunology</subject><subject>Humans</subject><subject>Ku Autoantigen</subject><subject>Medical sciences</subject><subject>Methimazole - therapeutic use</subject><subject>natural killer Tcell</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Platelet Transfusion</subject><subject>Propylthiouracil - therapeutic use</subject><subject>Purpura, Thrombocytopenic, Idiopathic - complications</subject><subject>Purpura, Thrombocytopenic, Idiopathic - immunology</subject><subject>Purpura, Thrombocytopenic, Idiopathic - therapy</subject><subject>Scleroderma, Systemic - complications</subject><subject>Scleroderma, Systemic - drug therapy</subject><subject>Scleroderma, Systemic - immunology</subject><subject>Steroids</subject><subject>thrombocytopenia</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkcFu1DAQhi0EokvhFZAvwCmL7ThOcqy6pVRUaqUtZ2vizLauEjvYzkp5AN6bpLu0Elz-Ocw3M7_mJ4RythZc1V-tSxgcdD221liHa8nXnNf1K7LiuayzUuTFa7JiNa8yMcsJeRfjI2N5VdbiLTnhohB83rQiv89cstmPkS618e2U3fpok90j3ZoOg28x9JBtFk2-n56akd7sMXQw0O3k2uB7pBvcY-cH6-7pZYA9xi90YyNCRAqupVd9Pzqkdw8z3HgzJT-gs4bejmEYA7wnb3bQRfxwrKfk57eLu_Pv2fXN5dX52XVmFFcpq2SbV8i45C0rK95KJYwxTAKTBcpCcQ6NqlABE7WBomgkq6AoC942TKomz0_J58PeIfhfI8akexsNdh049GPUpagEE4LNYHUATfAxBtzpIdgewqQ500sE-t8ItOR6iWAe_Xi8MTZz82Xw-PMZ-HQEIBrodgGcsfGFk4XMS7WY3R64x5jgHp8BCMnO0fznYD4unlz81cXOM20eIGh0-R8dR7Tr</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>KAMEI, Nozomu</creator><creator>YAMANE, Kiminori</creator><creator>YAMASHITA, Yasuyo</creator><creator>NAKANISHI, Shuhei</creator><creator>WATANABE, Hiroshi</creator><creator>FUJIKAWA, Rumi</creator><creator>HIYAMA, Keiko</creator><creator>ISHIOKA, Shinichi</creator><creator>MENDOZA, Giro</creator><creator>KOHNO, Nobuoki</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura</title><author>KAMEI, Nozomu ; YAMANE, Kiminori ; YAMASHITA, Yasuyo ; NAKANISHI, Shuhei ; WATANABE, Hiroshi ; FUJIKAWA, Rumi ; HIYAMA, Keiko ; ISHIOKA, Shinichi ; MENDOZA, Giro ; KOHNO, Nobuoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c616t-84d38e0141d0781d462ccc04a045e45611ab68e6a029ca55b408a5751db046b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>anti-thyroid drug</topic><topic>Antigens, Nuclear - immunology</topic><topic>Antithyroid Agents - therapeutic use</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Dermatomyositis - complications</topic><topic>Dermatomyositis - drug therapy</topic><topic>Dermatomyositis - immunology</topic><topic>DNA Helicases</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Graves Disease - complications</topic><topic>Graves Disease - drug therapy</topic><topic>Graves Disease - immunology</topic><topic>Humans</topic><topic>Ku Autoantigen</topic><topic>Medical sciences</topic><topic>Methimazole - therapeutic use</topic><topic>natural killer Tcell</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Platelet Transfusion</topic><topic>Propylthiouracil - therapeutic use</topic><topic>Purpura, Thrombocytopenic, Idiopathic - complications</topic><topic>Purpura, Thrombocytopenic, Idiopathic - immunology</topic><topic>Purpura, Thrombocytopenic, Idiopathic - therapy</topic><topic>Scleroderma, Systemic - complications</topic><topic>Scleroderma, Systemic - drug therapy</topic><topic>Scleroderma, Systemic - immunology</topic><topic>Steroids</topic><topic>thrombocytopenia</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAMEI, Nozomu</creatorcontrib><creatorcontrib>YAMANE, Kiminori</creatorcontrib><creatorcontrib>YAMASHITA, Yasuyo</creatorcontrib><creatorcontrib>NAKANISHI, Shuhei</creatorcontrib><creatorcontrib>WATANABE, Hiroshi</creatorcontrib><creatorcontrib>FUJIKAWA, Rumi</creatorcontrib><creatorcontrib>HIYAMA, Keiko</creatorcontrib><creatorcontrib>ISHIOKA, Shinichi</creatorcontrib><creatorcontrib>MENDOZA, Giro</creatorcontrib><creatorcontrib>KOHNO, Nobuoki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAMEI, Nozomu</au><au>YAMANE, Kiminori</au><au>YAMASHITA, Yasuyo</au><au>NAKANISHI, Shuhei</au><au>WATANABE, Hiroshi</au><au>FUJIKAWA, Rumi</au><au>HIYAMA, Keiko</au><au>ISHIOKA, Shinichi</au><au>MENDOZA, Giro</au><au>KOHNO, Nobuoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>41</volume><issue>12</issue><spage>1199</spage><epage>1203</epage><pages>1199-1203</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose γ-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases. (Internal Medicine 41: 1199-1203, 2002)</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>12521216</pmid><doi>10.2169/internalmedicine.41.1199</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-2918 |
| ispartof | Internal Medicine, 2002, Vol.41(12), pp.1199-1203 |
| issn | 0918-2918 1349-7235 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72820220 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Anti-Inflammatory Agents - therapeutic use anti-thyroid drug Antigens, Nuclear - immunology Antithyroid Agents - therapeutic use Autoantibodies - blood Biological and medical sciences Dermatomyositis - complications Dermatomyositis - drug therapy Dermatomyositis - immunology DNA Helicases DNA-Binding Proteins - immunology Endocrinopathies Female Graves Disease - complications Graves Disease - drug therapy Graves Disease - immunology Humans Ku Autoantigen Medical sciences Methimazole - therapeutic use natural killer Tcell Non tumoral diseases. Target tissue resistance. Benign neoplasms Platelet Transfusion Propylthiouracil - therapeutic use Purpura, Thrombocytopenic, Idiopathic - complications Purpura, Thrombocytopenic, Idiopathic - immunology Purpura, Thrombocytopenic, Idiopathic - therapy Scleroderma, Systemic - complications Scleroderma, Systemic - drug therapy Scleroderma, Systemic - immunology Steroids thrombocytopenia Thyroid. Thyroid axis (diseases) |
| title | Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T09%3A25%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-Ku%20Antibody-Positive%20Scleroderma-Dermatomyositis%20Overlap%20Syndrome%20Developing%20Graves'%20Disease%20and%20Immune%20Thrombocytopenic%20Purpura&rft.jtitle=Internal%20Medicine&rft.au=KAMEI,%20Nozomu&rft.date=2002-12-01&rft.volume=41&rft.issue=12&rft.spage=1199&rft.epage=1203&rft.pages=1199-1203&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.41.1199&rft_dat=%3Cproquest_cross%3E72820220%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72820220&rft_id=info:pmid/12521216&rfr_iscdi=true |