Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors

In various species, including humans, 5-hydroxytryptamine (5-HT) has been shown to exert positive chronotropic and inotropic cardiac effects through different types of receptors. The goal of the present study was to investigate the regulation by 5-HT of voltage-gated Ca2+ channels in human atrial my...

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Veröffentlicht in:	Molecular pharmacology 1992-02, Vol.41 (2), p.346-351
Hauptverfasser:	OUADID, H, SEGUIN, J, DUMUIS, A, BOCKAERT, NARGEOT, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anura Atrial Function Biological and medical sciences Calcium - metabolism Calcium - physiology Calcium Channels - drug effects Calcium Channels - physiology Cardiotonic Agents - pharmacology Cells, Cultured Cyclic AMP - metabolism Cyclic AMP - physiology Fundamental and applied biological sciences. Psychology Guinea Pigs Heart Heart - drug effects Heart - physiology Heart Atria - drug effects Humans Membrane Potentials - drug effects Membrane Potentials - physiology Myocardium - cytology Myocardium - metabolism Myocardium - ultrastructure Rabbits Rats Receptors, Serotonin - physiology Serotonin - pharmacology Species Specificity Vertebrates: cardiovascular system
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