Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine

The adjuvant activity of a single highly purified saponin from the soap bark tree Quillaja saponaria was evaluated by using it as a component in an experimental vaccine containing rHIV-1 envelope protein (HIV-1 160D) adsorbed to alum. BALB/c mice immunized with experimental vaccine formulations cont...

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Veröffentlicht in:	The Journal of immunology (1950) 1992-03, Vol.148 (5), p.1519-1525
Hauptverfasser:	Wu, JY, Gardner, BH, Murphy, CI, Seals, JR, Kensil, CR, Recchia, J, Beltz, GA, Newman, GW, Newman, MJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology AIDS Vaccines - immunology AIDS/HIV Animals Biological and medical sciences Esterases - biosynthesis Female Fundamental and applied biological sciences. Psychology Gene Products, env - immunology HIV Antibodies - analysis HIV Envelope Protein gp160 HIV-1 - immunology human immunodeficiency virus 1 Lymphocyte Activation Mice Mice, Inbred BALB C Microbiology Protein Precursors - immunology Saponins - pharmacology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology Virology
Online-Zugang:	Volltext
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