Immunity in Hepatitis C Infection
Polymerase chain reaction (PCR) and newer serologic assays for hepatitis C virus (HCV) were used to investigate 19 HCV cross-challenge episodes in chimpanzees. In these cross-challenges, 59% showed seroconversion after challenge, 33% showed reappearance of HCV-associated hepatocellular ultrastructur...
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| Veröffentlicht in: | The Journal of infectious diseases 1992-03, Vol.165 (3), p.438-443 |
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| container_title | The Journal of infectious diseases |
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| creator | Prince, Alfred M. Brotman, Betsy Huima, Tellervo Pascual, Donna Jaffery, Mumtaz Genevieve, Inchauspé |
| description | Polymerase chain reaction (PCR) and newer serologic assays for hepatitis C virus (HCV) were used to investigate 19 HCV cross-challenge episodes in chimpanzees. In these cross-challenges, 59% showed seroconversion after challenge, 33% showed reappearance of HCV-associated hepatocellular ultrastructural changes, 5 animals not PCR-positive at the time of challenge showed return ofPCR positivity, and 26% developed hepatitis after rechallenge. A total of 74% showed at least one of these signs of reinfection. The frequency of development of serologic and ultrastructural responses was, however, reduced in secondary compared with primary infections (P < .01). In 10 animals, the cross-challenge was done with heterologous strains, and in 9 with the originally infecting virus. There was no significant difference in the responses to homologous and heterologous challenges. The data suggest relatively weak immunity in HCV infections. |
| doi_str_mv | 10.1093/infdis/165.3.438 |
| format | Article |
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In these cross-challenges, 59% showed seroconversion after challenge, 33% showed reappearance of HCV-associated hepatocellular ultrastructural changes, 5 animals not PCR-positive at the time of challenge showed return ofPCR positivity, and 26% developed hepatitis after rechallenge. A total of 74% showed at least one of these signs of reinfection. The frequency of development of serologic and ultrastructural responses was, however, reduced in secondary compared with primary infections (P < .01). In 10 animals, the cross-challenge was done with heterologous strains, and in 9 with the originally infecting virus. There was no significant difference in the responses to homologous and heterologous challenges. The data suggest relatively weak immunity in HCV infections.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/165.3.438</identifier><identifier>PMID: 1538149</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Alanine Transaminase - blood ; Animals ; Antibodies ; Antigens, Viral ; Biological and medical sciences ; Blood Transfusion ; Capsid - immunology ; Dosage ; Follow-Up Studies ; Hepacivirus ; Hepatitis ; Hepatitis Antibodies - biosynthesis ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis C - etiology ; Hepatitis C - immunology ; hepatitis C virus ; Humans ; Immunity ; Infections ; Infectious diseases ; Liver - ultrastructure ; Major Articles ; Male ; Medical sciences ; Microscopy, Electron ; Middle Aged ; Pan troglodytes ; Polymerase Chain Reaction ; Recurrence ; Reinfection ; Viral Nonstructural Proteins ; Viral Proteins - immunology ; Viremia - etiology ; Viremia - immunology ; Viruses</subject><ispartof>The Journal of infectious diseases, 1992-03, Vol.165 (3), p.438-443</ispartof><rights>Copyright 1992 The University of Chicago</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-121a42b4e58e1205bfe899da8cfe4ed3c18897e256b6a202ba60818eeeee5c783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30112045$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30112045$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4645397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1538149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prince, Alfred M.</creatorcontrib><creatorcontrib>Brotman, Betsy</creatorcontrib><creatorcontrib>Huima, Tellervo</creatorcontrib><creatorcontrib>Pascual, Donna</creatorcontrib><creatorcontrib>Jaffery, Mumtaz</creatorcontrib><creatorcontrib>Genevieve, Inchauspé</creatorcontrib><title>Immunity in Hepatitis C Infection</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Polymerase chain reaction (PCR) and newer serologic assays for hepatitis C virus (HCV) were used to investigate 19 HCV cross-challenge episodes in chimpanzees. In these cross-challenges, 59% showed seroconversion after challenge, 33% showed reappearance of HCV-associated hepatocellular ultrastructural changes, 5 animals not PCR-positive at the time of challenge showed return ofPCR positivity, and 26% developed hepatitis after rechallenge. A total of 74% showed at least one of these signs of reinfection. The frequency of development of serologic and ultrastructural responses was, however, reduced in secondary compared with primary infections (P < .01). In 10 animals, the cross-challenge was done with heterologous strains, and in 9 with the originally infecting virus. There was no significant difference in the responses to homologous and heterologous challenges. The data suggest relatively weak immunity in HCV infections.</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens, Viral</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Capsid - immunology</subject><subject>Dosage</subject><subject>Follow-Up Studies</subject><subject>Hepacivirus</subject><subject>Hepatitis</subject><subject>Hepatitis Antibodies - biosynthesis</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C - etiology</subject><subject>Hepatitis C - immunology</subject><subject>hepatitis C virus</subject><subject>Humans</subject><subject>Immunity</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Liver - ultrastructure</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Pan troglodytes</subject><subject>Polymerase Chain Reaction</subject><subject>Recurrence</subject><subject>Reinfection</subject><subject>Viral Nonstructural Proteins</subject><subject>Viral Proteins - immunology</subject><subject>Viremia - etiology</subject><subject>Viremia - immunology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotVb3boQK4m5qbt6z1GJtwQe-QNyETJqBaGemTmbA_ntTptql2dzF-c4JfAgdAx4BTumFL_O5Dxcg-IiOGFU7qA-cykQIoLuojzEhCag03UcHIXxgjBkVsod6EVLA0j46nRVFW_pmNfTlcOqWpvGND8PxcFbmzja-Kg_RXm4WwR1t7gC9Tq5fxtPk9uFmNr68TSwD1iRAwDCSMceVA4J5lrv479womzvm5tSCUql0hItMGIJJZgRWoNz6cSsVHaDzbndZV1-tC40ufLBusTClq9qgJVEgOZb_giAIE5CmEcQdaOsqhNrleln7wtQrDViv9elOX2xwTXXUFysnm-02K9x8W-h8xfxsk5tgzSKvTWnjwC_GBOM0lduZj9BU9V9MMUQ1ERmgpMt9aNz3X27qTy0klVxP39713dPV_USKZ_1IfwAhqpA0</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>Prince, Alfred M.</creator><creator>Brotman, Betsy</creator><creator>Huima, Tellervo</creator><creator>Pascual, Donna</creator><creator>Jaffery, Mumtaz</creator><creator>Genevieve, Inchauspé</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19920301</creationdate><title>Immunity in Hepatitis C Infection</title><author>Prince, Alfred M. ; Brotman, Betsy ; Huima, Tellervo ; Pascual, Donna ; Jaffery, Mumtaz ; Genevieve, Inchauspé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-121a42b4e58e1205bfe899da8cfe4ed3c18897e256b6a202ba60818eeeee5c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens, Viral</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>Capsid - immunology</topic><topic>Dosage</topic><topic>Follow-Up Studies</topic><topic>Hepacivirus</topic><topic>Hepatitis</topic><topic>Hepatitis Antibodies - biosynthesis</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C - etiology</topic><topic>Hepatitis C - immunology</topic><topic>hepatitis C virus</topic><topic>Humans</topic><topic>Immunity</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Liver - ultrastructure</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Pan troglodytes</topic><topic>Polymerase Chain Reaction</topic><topic>Recurrence</topic><topic>Reinfection</topic><topic>Viral Nonstructural Proteins</topic><topic>Viral Proteins - immunology</topic><topic>Viremia - etiology</topic><topic>Viremia - immunology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prince, Alfred M.</creatorcontrib><creatorcontrib>Brotman, Betsy</creatorcontrib><creatorcontrib>Huima, Tellervo</creatorcontrib><creatorcontrib>Pascual, Donna</creatorcontrib><creatorcontrib>Jaffery, Mumtaz</creatorcontrib><creatorcontrib>Genevieve, Inchauspé</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prince, Alfred M.</au><au>Brotman, Betsy</au><au>Huima, Tellervo</au><au>Pascual, Donna</au><au>Jaffery, Mumtaz</au><au>Genevieve, Inchauspé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunity in Hepatitis C Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>165</volume><issue>3</issue><spage>438</spage><epage>443</epage><pages>438-443</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Polymerase chain reaction (PCR) and newer serologic assays for hepatitis C virus (HCV) were used to investigate 19 HCV cross-challenge episodes in chimpanzees. In these cross-challenges, 59% showed seroconversion after challenge, 33% showed reappearance of HCV-associated hepatocellular ultrastructural changes, 5 animals not PCR-positive at the time of challenge showed return ofPCR positivity, and 26% developed hepatitis after rechallenge. A total of 74% showed at least one of these signs of reinfection. The frequency of development of serologic and ultrastructural responses was, however, reduced in secondary compared with primary infections (P < .01). In 10 animals, the cross-challenge was done with heterologous strains, and in 9 with the originally infecting virus. There was no significant difference in the responses to homologous and heterologous challenges. The data suggest relatively weak immunity in HCV infections.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>1538149</pmid><doi>10.1093/infdis/165.3.438</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1992-03, Vol.165 (3), p.438-443 |
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| subjects | Alanine Transaminase - blood Animals Antibodies Antigens, Viral Biological and medical sciences Blood Transfusion Capsid - immunology Dosage Follow-Up Studies Hepacivirus Hepatitis Hepatitis Antibodies - biosynthesis Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis C - etiology Hepatitis C - immunology hepatitis C virus Humans Immunity Infections Infectious diseases Liver - ultrastructure Major Articles Male Medical sciences Microscopy, Electron Middle Aged Pan troglodytes Polymerase Chain Reaction Recurrence Reinfection Viral Nonstructural Proteins Viral Proteins - immunology Viremia - etiology Viremia - immunology Viruses |
| title | Immunity in Hepatitis C Infection |
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