Localization and characterization of secretin binding sites expressed by rat bile duct epithelium

The goal of the present studies was to identify and characterize the site of secretin action in the liver. Sections of normal and bile duct-ligated rat livers were used for in vitro 125I-secretin receptor autoradiography. Saturable binding was observed in both normal and bile duct-ligated livers but...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1992-03, Vol.102 (3), p.963-968
Hauptverfasser:	Farouk, Marwan, Vigna, Steven R., McVey, Douglas C., Meyers, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Bile Ducts - metabolism Binding Sites Binding, Competitive - drug effects Biological and medical sciences Cholecystokinin - pharmacology Dose-Response Relationship, Drug Epithelium - metabolism Fundamental and applied biological sciences. Psychology Gastric Inhibitory Polypeptide - pharmacology Glucagon - pharmacology Growth Hormone-Releasing Hormone - pharmacology Hyperplasia - metabolism Liver - metabolism Liver - pathology Male Rats Rats, Inbred Strains Receptors, G-Protein-Coupled Receptors, Gastrointestinal Hormone - biosynthesis Secretin - metabolism Vasoactive Intestinal Peptide - pharmacology Vertebrates: digestive system
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