Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE)
Reproductive hormones such as estrogen, progesterone, and testosterone are synthesized from a common cholesterol precursor pathway. We hypothesized that use of statins and the resultant lower blood lipoprotein levels would be associated with lower reproductive hormone levels in women. We also sought...
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| Veröffentlicht in: | The American journal of medicine 2002-12, Vol.113 (9), p.723-727 |
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| creator | Bairey Merz, C.Noel Olson, Marian B Johnson, B.Delia Bittner, Vera Hodgson, T.Keta Berga, Sarah L Braunstein, Glenn D Pepine, Carl J Reis, Steven E Sopko, George Kelsey, Sheryl F |
| description | Reproductive hormones such as estrogen, progesterone, and testosterone are synthesized from a common cholesterol precursor pathway. We hypothesized that use of statins and the resultant lower blood lipoprotein levels would be associated with lower reproductive hormone levels in women. We also sought to evaluate this association, independent of statin use, particularly among premenopausal women of childbearing age.
We enrolled 453 (114 pre-, 30 peri-, and 309 postmenopausal) women with coronary risk factors (mean [± SD] age, 58 ± 13 years) who were undergoing coronary angiography for suspected ischemia at four academic medical centers. Blood lipoprotein levels (total cholesterol, triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol) and serum reproductive hormone levels (estradiol, bioavailable estradiol, estrone, progesterone) were measured.
Use of statins was associated with lower lipoprotein levels, but not lower reproductive hormone levels, in all women. Mean estradiol levels were not significantly lower among premenopausal women with very low LDL cholesterol levels compared with women with higher LDL cholesterol levels (estradiol: 71 ± 52 pg/mL vs. 88 ± 67 pg/mL,
P = 0.32).
Among women undergoing coronary angiography for suspected myocardial ischemia, the use of statins, or lower cholesterol levels, are not associated with significantly lower levels of reproductive hormones. |
| doi_str_mv | 10.1016/S0002-9343(02)01366-9 |
| format | Article |
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We enrolled 453 (114 pre-, 30 peri-, and 309 postmenopausal) women with coronary risk factors (mean [± SD] age, 58 ± 13 years) who were undergoing coronary angiography for suspected ischemia at four academic medical centers. Blood lipoprotein levels (total cholesterol, triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol) and serum reproductive hormone levels (estradiol, bioavailable estradiol, estrone, progesterone) were measured.
Use of statins was associated with lower lipoprotein levels, but not lower reproductive hormone levels, in all women. Mean estradiol levels were not significantly lower among premenopausal women with very low LDL cholesterol levels compared with women with higher LDL cholesterol levels (estradiol: 71 ± 52 pg/mL vs. 88 ± 67 pg/mL,
P = 0.32).
Among women undergoing coronary angiography for suspected myocardial ischemia, the use of statins, or lower cholesterol levels, are not associated with significantly lower levels of reproductive hormones.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/S0002-9343(02)01366-9</identifier><identifier>PMID: 12517361</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Algorithms ; Anticholesteremic Agents - therapeutic use ; Biological and medical sciences ; Cholesterol ; Cholesterol - blood ; Climacteric ; Coronary Angiography ; Cross-Sectional Studies ; Drug therapy ; Drug toxicity and drugs side effects treatment ; Estradiol - blood ; Estrone - blood ; Female ; General and cellular metabolism. Vitamins ; Hormones ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Lipoproteins - blood ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Myocardial Ischemia - blood ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - diagnostic imaging ; Pharmacology. Drug treatments ; Postmenopause ; Premenopause ; Progesterone - blood ; Reproduction ; Risk Factors ; Women</subject><ispartof>The American journal of medicine, 2002-12, Vol.113 (9), p.723-727</ispartof><rights>2002 Excerpta Medica Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Dec 15, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-bf5624f203ae8a875efd1cff0b6b254e97304b4537f89f2d43baa6d635e7e2183</citedby><cites>FETCH-LOGICAL-c470t-bf5624f203ae8a875efd1cff0b6b254e97304b4537f89f2d43baa6d635e7e2183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002934302013669$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14464680$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12517361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bairey Merz, C.Noel</creatorcontrib><creatorcontrib>Olson, Marian B</creatorcontrib><creatorcontrib>Johnson, B.Delia</creatorcontrib><creatorcontrib>Bittner, Vera</creatorcontrib><creatorcontrib>Hodgson, T.Keta</creatorcontrib><creatorcontrib>Berga, Sarah L</creatorcontrib><creatorcontrib>Braunstein, Glenn D</creatorcontrib><creatorcontrib>Pepine, Carl J</creatorcontrib><creatorcontrib>Reis, Steven E</creatorcontrib><creatorcontrib>Sopko, George</creatorcontrib><creatorcontrib>Kelsey, Sheryl F</creatorcontrib><creatorcontrib>Women's Ischemia Syndrome Evaluation</creatorcontrib><title>Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE)</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Reproductive hormones such as estrogen, progesterone, and testosterone are synthesized from a common cholesterol precursor pathway. We hypothesized that use of statins and the resultant lower blood lipoprotein levels would be associated with lower reproductive hormone levels in women. We also sought to evaluate this association, independent of statin use, particularly among premenopausal women of childbearing age.
We enrolled 453 (114 pre-, 30 peri-, and 309 postmenopausal) women with coronary risk factors (mean [± SD] age, 58 ± 13 years) who were undergoing coronary angiography for suspected ischemia at four academic medical centers. Blood lipoprotein levels (total cholesterol, triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol) and serum reproductive hormone levels (estradiol, bioavailable estradiol, estrone, progesterone) were measured.
Use of statins was associated with lower lipoprotein levels, but not lower reproductive hormone levels, in all women. Mean estradiol levels were not significantly lower among premenopausal women with very low LDL cholesterol levels compared with women with higher LDL cholesterol levels (estradiol: 71 ± 52 pg/mL vs. 88 ± 67 pg/mL,
P = 0.32).
Among women undergoing coronary angiography for suspected myocardial ischemia, the use of statins, or lower cholesterol levels, are not associated with significantly lower levels of reproductive hormones.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Anticholesteremic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Climacteric</subject><subject>Coronary Angiography</subject><subject>Cross-Sectional Studies</subject><subject>Drug therapy</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Estradiol - blood</subject><subject>Estrone - blood</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Lipoproteins - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause</subject><subject>Premenopause</subject><subject>Progesterone - blood</subject><subject>Reproduction</subject><subject>Risk Factors</subject><subject>Women</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9qFTEUxoMo9nr1EZQgKC10NP9nxo3IpWqh4KKKy5DJnPGmZJKazNzSnVsfwdfzScz9gwU3rk5y-OU7X86H0FNKXlFC1etLQgirWi74MWEnhHKlqvYeWlApZVVTxe6jxV_kCD3K-apcSSvVQ3REmaQ1V3SBfq7W0UOeIEVf-XgDyYVveITeWTO5GE6xvQOwhw34U2xCjxNcp9jPdnIbwOuYxhggYxfwTRwhvMHTGvbH3z9-lX62axidwfk29Km0MWyMn3cj8PHX88uzk8fowWB8hieHukRf3p99Xn2sLj59OF-9u6isqMlUdYNUTAyMcAONaWoJQ0_tMJBOdUwKaGtORCckr4emHVgveGeM6hWXUAOjDV-il3vd4v_7XH6mx-IOvDcB4px1zRoqBG0L-Pwf8CrOKRRvmnHGec2LiSWSe8immHOCQV8nN5p0qynR26D0Lii9TUGXugtKb8WfHcTnrmz77tUhmQK8OAAmW-OHZIJ1-Y4TQgnVbA283XNQdrZxkHS2DoItCSawk-6j-4-VPyrOsgw</recordid><startdate>20021215</startdate><enddate>20021215</enddate><creator>Bairey Merz, C.Noel</creator><creator>Olson, Marian B</creator><creator>Johnson, B.Delia</creator><creator>Bittner, Vera</creator><creator>Hodgson, T.Keta</creator><creator>Berga, Sarah L</creator><creator>Braunstein, Glenn D</creator><creator>Pepine, Carl J</creator><creator>Reis, Steven E</creator><creator>Sopko, George</creator><creator>Kelsey, Sheryl F</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20021215</creationdate><title>Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE)</title><author>Bairey Merz, C.Noel ; Olson, Marian B ; Johnson, B.Delia ; Bittner, Vera ; Hodgson, T.Keta ; Berga, Sarah L ; Braunstein, Glenn D ; Pepine, Carl J ; Reis, Steven E ; Sopko, George ; Kelsey, Sheryl F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-bf5624f203ae8a875efd1cff0b6b254e97304b4537f89f2d43baa6d635e7e2183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Anticholesteremic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Climacteric</topic><topic>Coronary Angiography</topic><topic>Cross-Sectional Studies</topic><topic>Drug therapy</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Estradiol - blood</topic><topic>Estrone - blood</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Lipoproteins - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Myocardial Ischemia - blood</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause</topic><topic>Premenopause</topic><topic>Progesterone - blood</topic><topic>Reproduction</topic><topic>Risk Factors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bairey Merz, C.Noel</creatorcontrib><creatorcontrib>Olson, Marian B</creatorcontrib><creatorcontrib>Johnson, B.Delia</creatorcontrib><creatorcontrib>Bittner, Vera</creatorcontrib><creatorcontrib>Hodgson, T.Keta</creatorcontrib><creatorcontrib>Berga, Sarah L</creatorcontrib><creatorcontrib>Braunstein, Glenn D</creatorcontrib><creatorcontrib>Pepine, Carl J</creatorcontrib><creatorcontrib>Reis, Steven E</creatorcontrib><creatorcontrib>Sopko, George</creatorcontrib><creatorcontrib>Kelsey, Sheryl F</creatorcontrib><creatorcontrib>Women's Ischemia Syndrome Evaluation</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bairey Merz, C.Noel</au><au>Olson, Marian B</au><au>Johnson, B.Delia</au><au>Bittner, Vera</au><au>Hodgson, T.Keta</au><au>Berga, Sarah L</au><au>Braunstein, Glenn D</au><au>Pepine, Carl J</au><au>Reis, Steven E</au><au>Sopko, George</au><au>Kelsey, Sheryl F</au><aucorp>Women's Ischemia Syndrome Evaluation</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE)</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>2002-12-15</date><risdate>2002</risdate><volume>113</volume><issue>9</issue><spage>723</spage><epage>727</epage><pages>723-727</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>Reproductive hormones such as estrogen, progesterone, and testosterone are synthesized from a common cholesterol precursor pathway. We hypothesized that use of statins and the resultant lower blood lipoprotein levels would be associated with lower reproductive hormone levels in women. We also sought to evaluate this association, independent of statin use, particularly among premenopausal women of childbearing age.
We enrolled 453 (114 pre-, 30 peri-, and 309 postmenopausal) women with coronary risk factors (mean [± SD] age, 58 ± 13 years) who were undergoing coronary angiography for suspected ischemia at four academic medical centers. Blood lipoprotein levels (total cholesterol, triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol) and serum reproductive hormone levels (estradiol, bioavailable estradiol, estrone, progesterone) were measured.
Use of statins was associated with lower lipoprotein levels, but not lower reproductive hormone levels, in all women. Mean estradiol levels were not significantly lower among premenopausal women with very low LDL cholesterol levels compared with women with higher LDL cholesterol levels (estradiol: 71 ± 52 pg/mL vs. 88 ± 67 pg/mL,
P = 0.32).
Among women undergoing coronary angiography for suspected myocardial ischemia, the use of statins, or lower cholesterol levels, are not associated with significantly lower levels of reproductive hormones.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12517361</pmid><doi>10.1016/S0002-9343(02)01366-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Algorithms Anticholesteremic Agents - therapeutic use Biological and medical sciences Cholesterol Cholesterol - blood Climacteric Coronary Angiography Cross-Sectional Studies Drug therapy Drug toxicity and drugs side effects treatment Estradiol - blood Estrone - blood Female General and cellular metabolism. Vitamins Hormones Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lipoproteins - blood Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Myocardial Ischemia - blood Myocardial Ischemia - diagnosis Myocardial Ischemia - diagnostic imaging Pharmacology. Drug treatments Postmenopause Premenopause Progesterone - blood Reproduction Risk Factors Women |
| title | Cholesterol-lowering medication, cholesterol level, and reproductive hormones in women: the women’s ischemia syndrome evaluation (WISE) |
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