Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma?
Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa is a rare tumor, with only 15 cases reported to date. We report a case in a 61-year-old man complaining of dysphagia. The upper endoscopy revealed that the tumor measured 3 cm and was 22 cm distant from the incisivors. A hia...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2002-10, Vol.441 (4), p.406-411 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | CHATELAIN, Denis DE LAJARTE-THIROUARD, Anne-Sophie TIRET, Emmanuel FLEJOU, Jean-Francois |
| description | Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa is a rare tumor, with only 15 cases reported to date. We report a case in a 61-year-old man complaining of dysphagia. The upper endoscopy revealed that the tumor measured 3 cm and was 22 cm distant from the incisivors. A hiatal hernia with erosive esophagitis of the distal esophagus was present. On microscopic examination the tumor corresponded to a poorly differentiated adenocarcinoma immunoreactive for cytokeratin (CK) 7 and p53. The surrounding heterotopic gastric mucosa contained foci of intestinal metaplasia immunoreactive for CK7 in the surface epithelium and the entire glands and CK20 in the superficial epithelium and superficial glands. The CK7 and p53 positivity that we observed is very common in Barrett's adenocarcinomas. Moreover, intestinal metaplasia in heterotopic gastric mucosa shows the same CK7/CK20 pattern as specialized Barrett's mucosa. These common features shared by adenocarcinomas of the upper esophagus arising in heterotopic gastric mucosa and adenocarcinoma of the lower esophagus developing on Barrett's mucosa suggest that those two types of cancer have a common pathogenesis, related to gastroesophageal reflux disease. |
| doi_str_mv | 10.1007/s00428-002-0697-7 |
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We report a case in a 61-year-old man complaining of dysphagia. The upper endoscopy revealed that the tumor measured 3 cm and was 22 cm distant from the incisivors. A hiatal hernia with erosive esophagitis of the distal esophagus was present. On microscopic examination the tumor corresponded to a poorly differentiated adenocarcinoma immunoreactive for cytokeratin (CK) 7 and p53. The surrounding heterotopic gastric mucosa contained foci of intestinal metaplasia immunoreactive for CK7 in the surface epithelium and the entire glands and CK20 in the superficial epithelium and superficial glands. The CK7 and p53 positivity that we observed is very common in Barrett's adenocarcinomas. Moreover, intestinal metaplasia in heterotopic gastric mucosa shows the same CK7/CK20 pattern as specialized Barrett's mucosa. These common features shared by adenocarcinomas of the upper esophagus arising in heterotopic gastric mucosa and adenocarcinoma of the lower esophagus developing on Barrett's mucosa suggest that those two types of cancer have a common pathogenesis, related to gastroesophageal reflux disease.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-002-0697-7</identifier><identifier>PMID: 12516606</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adenocarcinoma - etiology ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Adenocarcinoma - therapy ; Barrett Esophagus - pathology ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Choristoma - complications ; Choristoma - metabolism ; Choristoma - pathology ; Choristoma - therapy ; Combined Modality Therapy ; Esophageal Neoplasms - etiology ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Esophagus ; Fatal Outcome ; Gastric Mucosa ; Gastroenterology. 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Abdomen ; Humans ; Immunohistochemistry ; Keratin-7 ; Keratins - metabolism ; Male ; Medical sciences ; Middle Aged ; Tumor Suppressor Protein p53 - metabolism ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2002-10, Vol.441 (4), p.406-411</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-a70d2f03ce32bb6ce86336dae3f709ff4b5d47cdacae7bc7d4439b908e026a533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14008172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12516606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHATELAIN, Denis</creatorcontrib><creatorcontrib>DE LAJARTE-THIROUARD, Anne-Sophie</creatorcontrib><creatorcontrib>TIRET, Emmanuel</creatorcontrib><creatorcontrib>FLEJOU, Jean-Francois</creatorcontrib><title>Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma?</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><description>Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa is a rare tumor, with only 15 cases reported to date. We report a case in a 61-year-old man complaining of dysphagia. The upper endoscopy revealed that the tumor measured 3 cm and was 22 cm distant from the incisivors. A hiatal hernia with erosive esophagitis of the distal esophagus was present. On microscopic examination the tumor corresponded to a poorly differentiated adenocarcinoma immunoreactive for cytokeratin (CK) 7 and p53. The surrounding heterotopic gastric mucosa contained foci of intestinal metaplasia immunoreactive for CK7 in the surface epithelium and the entire glands and CK20 in the superficial epithelium and superficial glands. The CK7 and p53 positivity that we observed is very common in Barrett's adenocarcinomas. Moreover, intestinal metaplasia in heterotopic gastric mucosa shows the same CK7/CK20 pattern as specialized Barrett's mucosa. These common features shared by adenocarcinomas of the upper esophagus arising in heterotopic gastric mucosa and adenocarcinoma of the lower esophagus developing on Barrett's mucosa suggest that those two types of cancer have a common pathogenesis, related to gastroesophageal reflux disease.</description><subject>Adenocarcinoma - etiology</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Barrett Esophagus - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Choristoma - complications</subject><subject>Choristoma - metabolism</subject><subject>Choristoma - pathology</subject><subject>Choristoma - therapy</subject><subject>Combined Modality Therapy</subject><subject>Esophageal Neoplasms - etiology</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophagus</subject><subject>Fatal Outcome</subject><subject>Gastric Mucosa</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratin-7</subject><subject>Keratins - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1v1DAURS0EokPhB7BB3gCrwLOdsRM2qFTlQ6rEBtbWi_MyMZrEwc8RYsVfJ9WMVHV1N-feKx0hXip4pwDcewaodVMB6Aps6yr3SOxUbXSlDbjHYgdtva-sUe5CPGP-tXGqUfapuFB6r6wFuxP_rnqaU8Ac4pwmlGmQZSS5LgtlSZyWEQ8rS8yR43yQcZYjFcqppCUGeUAuectpDYnxgwxpmtIsFyxjOtBMHFn-iWWUnzBnKuXttvTg7-Nz8WTAI9OLc16Kn59vflx_rW6_f_l2fXVbBaNdqdBBrwcwgYzuOhuoscbYHskMDtphqLt9X7vQY0ByXXB9XZu2a6Eh0Bb3xlyKN6fdJaffK3HxU-RAxyPOlFb2TjdKqxY2UJ3AkBNzpsEvOU6Y_3oF_s66P1n3m01_Z927rfPqPL52E_X3jbPmDXh9BpADHoeMc4h8z9UAjXLa_AeCr42q</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>CHATELAIN, Denis</creator><creator>DE LAJARTE-THIROUARD, Anne-Sophie</creator><creator>TIRET, Emmanuel</creator><creator>FLEJOU, Jean-Francois</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma?</title><author>CHATELAIN, Denis ; DE LAJARTE-THIROUARD, Anne-Sophie ; TIRET, Emmanuel ; FLEJOU, Jean-Francois</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-a70d2f03ce32bb6ce86336dae3f709ff4b5d47cdacae7bc7d4439b908e026a533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adenocarcinoma - etiology</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - therapy</topic><topic>Barrett Esophagus - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Choristoma - complications</topic><topic>Choristoma - metabolism</topic><topic>Choristoma - pathology</topic><topic>Choristoma - therapy</topic><topic>Combined Modality Therapy</topic><topic>Esophageal Neoplasms - etiology</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophagus</topic><topic>Fatal Outcome</topic><topic>Gastric Mucosa</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratin-7</topic><topic>Keratins - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHATELAIN, Denis</creatorcontrib><creatorcontrib>DE LAJARTE-THIROUARD, Anne-Sophie</creatorcontrib><creatorcontrib>TIRET, Emmanuel</creatorcontrib><creatorcontrib>FLEJOU, Jean-Francois</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHATELAIN, Denis</au><au>DE LAJARTE-THIROUARD, Anne-Sophie</au><au>TIRET, Emmanuel</au><au>FLEJOU, Jean-Francois</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma?</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><addtitle>Virchows Arch</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>441</volume><issue>4</issue><spage>406</spage><epage>411</epage><pages>406-411</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa is a rare tumor, with only 15 cases reported to date. We report a case in a 61-year-old man complaining of dysphagia. The upper endoscopy revealed that the tumor measured 3 cm and was 22 cm distant from the incisivors. A hiatal hernia with erosive esophagitis of the distal esophagus was present. On microscopic examination the tumor corresponded to a poorly differentiated adenocarcinoma immunoreactive for cytokeratin (CK) 7 and p53. The surrounding heterotopic gastric mucosa contained foci of intestinal metaplasia immunoreactive for CK7 in the surface epithelium and the entire glands and CK20 in the superficial epithelium and superficial glands. The CK7 and p53 positivity that we observed is very common in Barrett's adenocarcinomas. Moreover, intestinal metaplasia in heterotopic gastric mucosa shows the same CK7/CK20 pattern as specialized Barrett's mucosa. 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| subjects | Adenocarcinoma - etiology Adenocarcinoma - metabolism Adenocarcinoma - secondary Adenocarcinoma - therapy Barrett Esophagus - pathology Biological and medical sciences Biomarkers, Tumor - metabolism Choristoma - complications Choristoma - metabolism Choristoma - pathology Choristoma - therapy Combined Modality Therapy Esophageal Neoplasms - etiology Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagus Fatal Outcome Gastric Mucosa Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Keratin-7 Keratins - metabolism Male Medical sciences Middle Aged Tumor Suppressor Protein p53 - metabolism Tumors |
| title | Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma? |
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