Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age
In the UK an accelerated schedule for immunisation against diphtheria, tetanus, and pertussis (injections at 2, 3, and 4 months of age) was introduced in 1990 to replace the more widely spaced schedule of 3, 5, and 9 months. There is concern, however, that the new schedule may be less immunogenic an...
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| Veröffentlicht in: | The Lancet (British edition) 1992-02, Vol.339 (8792), p.507-510 |
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| creator | Booy, R. Taylor, S. Tudor-Williams, G. Moxon, E.R. Aitken, S.J.M. Griffiths, H. Chapel, H.M. Ashworth, L.A.E. Macfarlane, J.A. Mayon-White, R.T. |
| description | In the UK an accelerated schedule for immunisation against diphtheria, tetanus, and pertussis (injections at 2, 3, and 4 months of age) was introduced in 1990 to replace the more widely spaced schedule of 3, 5, and 9 months. There is concern, however, that the new schedule may be less immunogenic and therefore less protective than the old schedule. We have measured serum concentrations of antibodies against diphtheria, pertussis, and tetanus in infants immunised according to the two regimens. Both schedules resulted in protective concentrations of antibody against tetanus and diphtheria and in satisfactory antibody responses to three pertussis antigens (filamentous haemagglutinin, pertussis toxin, fimbriae). However, immunisation by the old schedule led to significantly higher antibody concentrations against both diphtheria and tetanus than did immunisation by the new schedule (p < 0·01). In infants immunised with the new schedule, postimmunisation antibody concentrations against tetanus toxoid and against two pertussis antigens (pertussis toxin and fimbriae) were significantly lower in infants in whom pre-immunisation (maternally derived) antibody concentrations were high (p < 0·02). The findings suggest that with an accelerated immunisation schedule maternal antibodies can have an inhibitory effect on the responses to immunisation against tetanus and pertussis. |
| doi_str_mv | 10.1016/0140-6736(92)90336-2 |
| format | Article |
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There is concern, however, that the new schedule may be less immunogenic and therefore less protective than the old schedule. We have measured serum concentrations of antibodies against diphtheria, pertussis, and tetanus in infants immunised according to the two regimens. Both schedules resulted in protective concentrations of antibody against tetanus and diphtheria and in satisfactory antibody responses to three pertussis antigens (filamentous haemagglutinin, pertussis toxin, fimbriae). However, immunisation by the old schedule led to significantly higher antibody concentrations against both diphtheria and tetanus than did immunisation by the new schedule (p < 0·01). In infants immunised with the new schedule, postimmunisation antibody concentrations against tetanus toxoid and against two pertussis antigens (pertussis toxin and fimbriae) were significantly lower in infants in whom pre-immunisation (maternally derived) antibody concentrations were high (p < 0·02). The findings suggest that with an accelerated immunisation schedule maternal antibodies can have an inhibitory effect on the responses to immunisation against tetanus and pertussis.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(92)90336-2</identifier><identifier>PMID: 1346876</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Antibodies, Bacterial - biosynthesis ; Biological and medical sciences ; Bordetella pertussis - immunology ; Clostridium tetani - immunology ; Corynebacterium diphtheriae - immunology ; Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage ; Diphtheria-Tetanus-Pertussis Vaccine - immunology ; Disease ; Epidemiology. Vaccinations ; General aspects ; Humans ; Immunization ; Immunization Schedule ; Immunogenicity ; Infant ; Infants ; Infectious diseases ; Medical research ; Medical sciences ; Toxins ; Vaccines</subject><ispartof>The Lancet (British edition), 1992-02, Vol.339 (8792), p.507-510</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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There is concern, however, that the new schedule may be less immunogenic and therefore less protective than the old schedule. We have measured serum concentrations of antibodies against diphtheria, pertussis, and tetanus in infants immunised according to the two regimens. Both schedules resulted in protective concentrations of antibody against tetanus and diphtheria and in satisfactory antibody responses to three pertussis antigens (filamentous haemagglutinin, pertussis toxin, fimbriae). However, immunisation by the old schedule led to significantly higher antibody concentrations against both diphtheria and tetanus than did immunisation by the new schedule (p < 0·01). In infants immunised with the new schedule, postimmunisation antibody concentrations against tetanus toxoid and against two pertussis antigens (pertussis toxin and fimbriae) were significantly lower in infants in whom pre-immunisation (maternally derived) antibody concentrations were high (p < 0·02). The findings suggest that with an accelerated immunisation schedule maternal antibodies can have an inhibitory effect on the responses to immunisation against tetanus and pertussis.</description><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Bordetella pertussis - immunology</subject><subject>Clostridium tetani - immunology</subject><subject>Corynebacterium diphtheriae - immunology</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - immunology</subject><subject>Disease</subject><subject>Epidemiology. 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Vaccinations</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Immunogenicity</topic><topic>Infant</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Toxins</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Booy, R.</creatorcontrib><creatorcontrib>Taylor, S.</creatorcontrib><creatorcontrib>Tudor-Williams, G.</creatorcontrib><creatorcontrib>Moxon, E.R.</creatorcontrib><creatorcontrib>Aitken, S.J.M.</creatorcontrib><creatorcontrib>Griffiths, H.</creatorcontrib><creatorcontrib>Chapel, H.M.</creatorcontrib><creatorcontrib>Ashworth, L.A.E.</creatorcontrib><creatorcontrib>Macfarlane, J.A.</creatorcontrib><creatorcontrib>Mayon-White, R.T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest - 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There is concern, however, that the new schedule may be less immunogenic and therefore less protective than the old schedule. We have measured serum concentrations of antibodies against diphtheria, pertussis, and tetanus in infants immunised according to the two regimens. Both schedules resulted in protective concentrations of antibody against tetanus and diphtheria and in satisfactory antibody responses to three pertussis antigens (filamentous haemagglutinin, pertussis toxin, fimbriae). However, immunisation by the old schedule led to significantly higher antibody concentrations against both diphtheria and tetanus than did immunisation by the new schedule (p < 0·01). In infants immunised with the new schedule, postimmunisation antibody concentrations against tetanus toxoid and against two pertussis antigens (pertussis toxin and fimbriae) were significantly lower in infants in whom pre-immunisation (maternally derived) antibody concentrations were high (p < 0·02). The findings suggest that with an accelerated immunisation schedule maternal antibodies can have an inhibitory effect on the responses to immunisation against tetanus and pertussis.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>1346876</pmid><doi>10.1016/0140-6736(92)90336-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1992-02, Vol.339 (8792), p.507-510 |
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| language | eng |
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| subjects | Antibodies, Bacterial - biosynthesis Biological and medical sciences Bordetella pertussis - immunology Clostridium tetani - immunology Corynebacterium diphtheriae - immunology Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage Diphtheria-Tetanus-Pertussis Vaccine - immunology Disease Epidemiology. Vaccinations General aspects Humans Immunization Immunization Schedule Immunogenicity Infant Infants Infectious diseases Medical research Medical sciences Toxins Vaccines |
| title | Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age |
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