Reduced Levels of Total Leukocytes and Neutrophils in Norwegian Cattle Selected for Decreased Mastitis Incidence
Two groups of Norwegian Cattle showing significant genetic differences in clinical mastitis susceptibility were examined for hematological changes at three stages of lactation. Blood samples were taken from 91 healthy Norwegian Cattle cows and heifers belonging either to a high protein yield group o...
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| Veröffentlicht in: | Journal of dairy science 2002-12, Vol.85 (12), p.3470-3475 |
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| creator | Kulberg, S. Storset, A.K. Heringstad, B. Larsen, H.J.S. |
| description | Two groups of Norwegian Cattle showing significant genetic differences in clinical mastitis susceptibility were examined for hematological changes at three stages of lactation. Blood samples were taken from 91 healthy Norwegian Cattle cows and heifers belonging either to a high protein yield group or to a low clinical mastitis group and analyzed for hematological properties and serum cortisol levels at three stages of lactation. All animals were free of intramammary infections at the time of sampling.
All cows had increased total white blood cells, neutrophils, and neutrophil/lymphocyte ratio as parturition approached, with peak levels at parturition. Cows selected for low clinical mastitis had lower levels of total white blood cells and neutrophils compared with cows selected for high protein yield throughout all three periods. The difference was significant prepartum. Cows from the low clinical mastitis group also had lower neutrophil/lymphocyte ratios and lower serum cortisol levels than those in the high protein yield group. A significant positive correlation was found between cortisol and total white blood cells and neutrophils, respectively.
We conclude that selection for lower mastitis incidence in the low clinical mastitis group is associated with a significant decrease in total white blood cells and neutrophils in blood prepartum. Results from the present study, and the genetic difference in mastitis incidence observed in the groups, indicates that increased leukocyte mobilization at certain stages of lactation may be associated with increased susceptibility to mastitis. |
| doi_str_mv | 10.3168/jds.S0022-0302(02)74435-4 |
| format | Article |
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All cows had increased total white blood cells, neutrophils, and neutrophil/lymphocyte ratio as parturition approached, with peak levels at parturition. Cows selected for low clinical mastitis had lower levels of total white blood cells and neutrophils compared with cows selected for high protein yield throughout all three periods. The difference was significant prepartum. Cows from the low clinical mastitis group also had lower neutrophil/lymphocyte ratios and lower serum cortisol levels than those in the high protein yield group. A significant positive correlation was found between cortisol and total white blood cells and neutrophils, respectively.
We conclude that selection for lower mastitis incidence in the low clinical mastitis group is associated with a significant decrease in total white blood cells and neutrophils in blood prepartum. Results from the present study, and the genetic difference in mastitis incidence observed in the groups, indicates that increased leukocyte mobilization at certain stages of lactation may be associated with increased susceptibility to mastitis.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(02)74435-4</identifier><identifier>PMID: 12512620</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>Animal productions ; Animals ; Biological and medical sciences ; Cattle - blood ; Cattle - genetics ; dairy cow ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Hydrocortisone - blood ; Labor, Obstetric ; Lactation ; leukocyte ; Leukocyte Count ; Mastitis, Bovine - blood ; Mastitis, Bovine - genetics ; Neutrophils ; Norway ; parturition ; Pregnancy ; selected cattle group ; Selection, Genetic ; Terrestrial animal productions ; Vertebrates</subject><ispartof>Journal of dairy science, 2002-12, Vol.85 (12), p.3470-3475</ispartof><rights>2002 American Dairy Science Association</rights><rights>2003 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Dec 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-a8dd7ee6c448f1a18cee05639a46dabe33269993a8e5029eecea3045e572a2cf3</citedby><cites>FETCH-LOGICAL-c513t-a8dd7ee6c448f1a18cee05639a46dabe33269993a8e5029eecea3045e572a2cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.S0022-0302(02)74435-4$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14429892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12512620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulberg, S.</creatorcontrib><creatorcontrib>Storset, A.K.</creatorcontrib><creatorcontrib>Heringstad, B.</creatorcontrib><creatorcontrib>Larsen, H.J.S.</creatorcontrib><title>Reduced Levels of Total Leukocytes and Neutrophils in Norwegian Cattle Selected for Decreased Mastitis Incidence</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Two groups of Norwegian Cattle showing significant genetic differences in clinical mastitis susceptibility were examined for hematological changes at three stages of lactation. Blood samples were taken from 91 healthy Norwegian Cattle cows and heifers belonging either to a high protein yield group or to a low clinical mastitis group and analyzed for hematological properties and serum cortisol levels at three stages of lactation. All animals were free of intramammary infections at the time of sampling.
All cows had increased total white blood cells, neutrophils, and neutrophil/lymphocyte ratio as parturition approached, with peak levels at parturition. Cows selected for low clinical mastitis had lower levels of total white blood cells and neutrophils compared with cows selected for high protein yield throughout all three periods. The difference was significant prepartum. Cows from the low clinical mastitis group also had lower neutrophil/lymphocyte ratios and lower serum cortisol levels than those in the high protein yield group. A significant positive correlation was found between cortisol and total white blood cells and neutrophils, respectively.
We conclude that selection for lower mastitis incidence in the low clinical mastitis group is associated with a significant decrease in total white blood cells and neutrophils in blood prepartum. Results from the present study, and the genetic difference in mastitis incidence observed in the groups, indicates that increased leukocyte mobilization at certain stages of lactation may be associated with increased susceptibility to mastitis.</description><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle - blood</subject><subject>Cattle - genetics</subject><subject>dairy cow</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Hydrocortisone - blood</subject><subject>Labor, Obstetric</subject><subject>Lactation</subject><subject>leukocyte</subject><subject>Leukocyte Count</subject><subject>Mastitis, Bovine - blood</subject><subject>Mastitis, Bovine - genetics</subject><subject>Neutrophils</subject><subject>Norway</subject><subject>parturition</subject><subject>Pregnancy</subject><subject>selected cattle group</subject><subject>Selection, Genetic</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkd1rFDEUxYModq3-CzIKfj1MzedM8ijrV2GtYOtzSJM73azZyZpkWvrfm-kuFnwSAuHC75x7OQehFwSfMNLJ9xuXT84xprTFDNO3mL7rOWei5Q_QgggqWkaUfIgWf5Ej9CTnTR0JxeIxOiJUENpRvEC7H-AmC65ZwTWE3MShuYjFhDpPv6K9LZAbM7rmDKaS4m7tK-PH5iymG7jyZmyWppQAzTkEsKX6DDE1H8EmMLlO30wuvvjcnI7WOxgtPEWPBhMyPDv8x-jn508Xy6_t6vuX0-WHVWsFYaU10rkeoLOcy4EYIi0AFh1ThnfOXAJjtFNKMSNBYKoALBiGuQDRU0PtwI7R673vLsXfE-Sitz5bCMGMEKeseyqxZBRX8OU_4CZOaay3aaKExEyRGVJ7yKaYc4JB75LfmnSrCdZzJ7p2ou860XPgur67TjSv2ueHBdPlFty98lBCBV4dAJOtCUMyNax8z3FOlVS0cm_23NpfrW98Ap23JoRqS-b1UlRLzXg_Oy73ZK0Urj0kna2f03dVZYt20f_H4X8A3R65Rw</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Kulberg, S.</creator><creator>Storset, A.K.</creator><creator>Heringstad, B.</creator><creator>Larsen, H.J.S.</creator><general>Elsevier Inc</general><general>Am Dairy Sci Assoc</general><general>American Dairy Science Association</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Reduced Levels of Total Leukocytes and Neutrophils in Norwegian Cattle Selected for Decreased Mastitis Incidence</title><author>Kulberg, S. ; Storset, A.K. ; Heringstad, B. ; Larsen, H.J.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-a8dd7ee6c448f1a18cee05639a46dabe33269993a8e5029eecea3045e572a2cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle - blood</topic><topic>Cattle - genetics</topic><topic>dairy cow</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Hydrocortisone - blood</topic><topic>Labor, Obstetric</topic><topic>Lactation</topic><topic>leukocyte</topic><topic>Leukocyte Count</topic><topic>Mastitis, Bovine - blood</topic><topic>Mastitis, Bovine - genetics</topic><topic>Neutrophils</topic><topic>Norway</topic><topic>parturition</topic><topic>Pregnancy</topic><topic>selected cattle group</topic><topic>Selection, Genetic</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulberg, S.</creatorcontrib><creatorcontrib>Storset, A.K.</creatorcontrib><creatorcontrib>Heringstad, B.</creatorcontrib><creatorcontrib>Larsen, H.J.S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulberg, S.</au><au>Storset, A.K.</au><au>Heringstad, B.</au><au>Larsen, H.J.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Levels of Total Leukocytes and Neutrophils in Norwegian Cattle Selected for Decreased Mastitis Incidence</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>85</volume><issue>12</issue><spage>3470</spage><epage>3475</epage><pages>3470-3475</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>Two groups of Norwegian Cattle showing significant genetic differences in clinical mastitis susceptibility were examined for hematological changes at three stages of lactation. Blood samples were taken from 91 healthy Norwegian Cattle cows and heifers belonging either to a high protein yield group or to a low clinical mastitis group and analyzed for hematological properties and serum cortisol levels at three stages of lactation. All animals were free of intramammary infections at the time of sampling.
All cows had increased total white blood cells, neutrophils, and neutrophil/lymphocyte ratio as parturition approached, with peak levels at parturition. Cows selected for low clinical mastitis had lower levels of total white blood cells and neutrophils compared with cows selected for high protein yield throughout all three periods. The difference was significant prepartum. Cows from the low clinical mastitis group also had lower neutrophil/lymphocyte ratios and lower serum cortisol levels than those in the high protein yield group. A significant positive correlation was found between cortisol and total white blood cells and neutrophils, respectively.
We conclude that selection for lower mastitis incidence in the low clinical mastitis group is associated with a significant decrease in total white blood cells and neutrophils in blood prepartum. Results from the present study, and the genetic difference in mastitis incidence observed in the groups, indicates that increased leukocyte mobilization at certain stages of lactation may be associated with increased susceptibility to mastitis.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>12512620</pmid><doi>10.3168/jds.S0022-0302(02)74435-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal productions Animals Biological and medical sciences Cattle - blood Cattle - genetics dairy cow Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Hydrocortisone - blood Labor, Obstetric Lactation leukocyte Leukocyte Count Mastitis, Bovine - blood Mastitis, Bovine - genetics Neutrophils Norway parturition Pregnancy selected cattle group Selection, Genetic Terrestrial animal productions Vertebrates |
| title | Reduced Levels of Total Leukocytes and Neutrophils in Norwegian Cattle Selected for Decreased Mastitis Incidence |
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