Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides

A series of 2',3'-dideoxy-4'-thionucleoside analogues of purines and pyrimidines, including 4'-thioddI (17), 4'-thioddC (27), and 4'-thioAZT (34), were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). A stereospecific s...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-02, Vol.35 (3), p.533-538
Hauptverfasser:	Secrist, John A, Riggs, Robert M, Tiwari, Kamal N, Montgomery, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Dideoxynucleosides - chemical synthesis Dideoxynucleosides - pharmacology HIV - drug effects human immunodeficiency virus
Online-Zugang:	Volltext
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