Outcome of hepatic amebic abscesses managed with three different therapeutic strategies
Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N = 11 patients), open surgical drainage (N = 9 patients), and percutaneous drainage using ultrasound guidance fo...
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| Veröffentlicht in: | Digestive diseases and sciences 1992-02, Vol.37 (2), p.240-247 |
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| container_title | Digestive diseases and sciences |
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| creator | FILICE, C DI PERRI, G STROSSELLI, M BRUNETTI, E DUGHETTI, S VAN THIEL, D. H SCOTTI-FOGLIENI, C |
| description | Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N = 11 patients), open surgical drainage (N = 9 patients), and percutaneous drainage using ultrasound guidance followed by intralesional nitroimidazole administration (N = 31 patients). The results with each form of therapy were assessed clinically and by abdominal ultrasound. Patients receiving combined US-guided drainage and intralesional chemotherapy experienced a faster and overall better clinical response, which was confirmed also by sonographic follow-up of the hepatic lesions. This better response was associated with faster resolution, fewer relapses, and less residual hepatic scarring than either with medical therapy alone or open surgical drainage combined with medical therapy. |
| doi_str_mv | 10.1007/BF01308178 |
| format | Article |
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H</creatorcontrib><creatorcontrib>SCOTTI-FOGLIENI, C</creatorcontrib><title>Outcome of hepatic amebic abscesses managed with three different therapeutic strategies</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N = 11 patients), open surgical drainage (N = 9 patients), and percutaneous drainage using ultrasound guidance followed by intralesional nitroimidazole administration (N = 31 patients). The results with each form of therapy were assessed clinically and by abdominal ultrasound. Patients receiving combined US-guided drainage and intralesional chemotherapy experienced a faster and overall better clinical response, which was confirmed also by sonographic follow-up of the hepatic lesions. This better response was associated with faster resolution, fewer relapses, and less residual hepatic scarring than either with medical therapy alone or open surgical drainage combined with medical therapy.</description><subject>Adult</subject><subject>Amibiasis</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Drainage - methods</subject><subject>Entamoeba histolytica</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Injections, Intralesional</subject><subject>Liver Abscess, Amebic - complications</subject><subject>Liver Abscess, Amebic - diagnostic imaging</subject><subject>Liver Abscess, Amebic - pathology</subject><subject>Liver Abscess, Amebic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitroimidazoles - therapeutic use</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Ultrasonography</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLAzEQhYMotVYv3oU9iAehOkk2ye5Ri1Wh0IvicZnNTtqVbrcmWcR_75YWe3Qub4b3zTA8xi453HEAc_84BS4h4yY7YkOujBwLpbNjNgSu-55zfcrOQvgEgNxwPWADbqSSqRiyj3kXbdtQ0rpkSRuMtU2woXIrZbAUAoWkwTUuqEq-67hM4tITJVXtHHlax34mjxvqtpsheoy0qCmcsxOHq0AXex2x9-nT2-RlPJs_v04eZmMrlIljRGkwJ52bXDuSCpxFXaVQlVxx0Bql0EZIR9qUlYQ0E6nkGmQmVOYybeWI3ezubnz71VGIRVP3b69WuKa2C4URGRjZ139gn5Tg2qgevN2B1rcheHLFxtcN-p-CQ7GNuzjE3cNX-6td2VB1QHf59v713sdgceU8rm0d_jDF8zQFKX8BKuiF2A</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>FILICE, C</creator><creator>DI PERRI, G</creator><creator>STROSSELLI, M</creator><creator>BRUNETTI, E</creator><creator>DUGHETTI, S</creator><creator>VAN THIEL, D. 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H ; SCOTTI-FOGLIENI, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-aa37a9e69796fe350fca6d40db151066a326723fe67bd304824316038258f86c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Amibiasis</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Drainage - methods</topic><topic>Entamoeba histolytica</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Injections, Intralesional</topic><topic>Liver Abscess, Amebic - complications</topic><topic>Liver Abscess, Amebic - diagnostic imaging</topic><topic>Liver Abscess, Amebic - pathology</topic><topic>Liver Abscess, Amebic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitroimidazoles - therapeutic use</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FILICE, C</creatorcontrib><creatorcontrib>DI PERRI, G</creatorcontrib><creatorcontrib>STROSSELLI, M</creatorcontrib><creatorcontrib>BRUNETTI, E</creatorcontrib><creatorcontrib>DUGHETTI, S</creatorcontrib><creatorcontrib>VAN THIEL, D. 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H</au><au>SCOTTI-FOGLIENI, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome of hepatic amebic abscesses managed with three different therapeutic strategies</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1992-02</date><risdate>1992</risdate><volume>37</volume><issue>2</issue><spage>240</spage><epage>247</epage><pages>240-247</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N = 11 patients), open surgical drainage (N = 9 patients), and percutaneous drainage using ultrasound guidance followed by intralesional nitroimidazole administration (N = 31 patients). The results with each form of therapy were assessed clinically and by abdominal ultrasound. Patients receiving combined US-guided drainage and intralesional chemotherapy experienced a faster and overall better clinical response, which was confirmed also by sonographic follow-up of the hepatic lesions. This better response was associated with faster resolution, fewer relapses, and less residual hepatic scarring than either with medical therapy alone or open surgical drainage combined with medical therapy.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>1735342</pmid><doi>10.1007/BF01308178</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Digestive diseases and sciences, 1992-02, Vol.37 (2), p.240-247 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Amibiasis Biological and medical sciences Combined Modality Therapy Drainage - methods Entamoeba histolytica Female Human protozoal diseases Humans Infectious diseases Injections, Intralesional Liver Abscess, Amebic - complications Liver Abscess, Amebic - diagnostic imaging Liver Abscess, Amebic - pathology Liver Abscess, Amebic - therapy Male Medical sciences Middle Aged Nitroimidazoles - therapeutic use Parasitic diseases Protozoal diseases Ultrasonography |
| title | Outcome of hepatic amebic abscesses managed with three different therapeutic strategies |
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