Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome
Cytomegalovirus (CMV) retinitis is the most common ocular opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). The disease is inexorably progressive when untreated, making early detection and prompt treatment essential for preservation of functional vision. The retinit...
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| Veröffentlicht in: | The American journal of medicine 1992-02, Vol.92 (2), p.S12-S16 |
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| container_title | The American journal of medicine |
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| creator | Heinemann, Murk-Hein |
| description | Cytomegalovirus (CMV) retinitis is the most common ocular opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). The disease is inexorably progressive when untreated, making early detection and prompt treatment essential for preservation of functional vision. The retinitis tends to be unilateral at presentation but often becomes bilateral as it progresses. Lesions may be unifocal or multifocal and may appear in the posterior retina or peripheral retina. Primary ophthalmoscopic features of CMV retinitis include white granular zones of retinal necrosis, variable degrees of associated hemorrhage, and low-grade iritis and vitritis. Differential diagnosis is aided by characteristic features of CMV retinitis and other AIDS-related retinopathies. Initial treatment with ganciclovir or foscarnet has been found to stabilize retinitis, and maintenance therapy with either has been shown to prolong the time to retinitis progression. Further studies should help to determine the optimal approach to treatment of the disease. |
| doi_str_mv | 10.1016/0002-9343(92)90331-5 |
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The disease is inexorably progressive when untreated, making early detection and prompt treatment essential for preservation of functional vision. The retinitis tends to be unilateral at presentation but often becomes bilateral as it progresses. Lesions may be unifocal or multifocal and may appear in the posterior retina or peripheral retina. Primary ophthalmoscopic features of CMV retinitis include white granular zones of retinal necrosis, variable degrees of associated hemorrhage, and low-grade iritis and vitritis. Differential diagnosis is aided by characteristic features of CMV retinitis and other AIDS-related retinopathies. Initial treatment with ganciclovir or foscarnet has been found to stabilize retinitis, and maintenance therapy with either has been shown to prolong the time to retinitis progression. 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The disease is inexorably progressive when untreated, making early detection and prompt treatment essential for preservation of functional vision. The retinitis tends to be unilateral at presentation but often becomes bilateral as it progresses. Lesions may be unifocal or multifocal and may appear in the posterior retina or peripheral retina. Primary ophthalmoscopic features of CMV retinitis include white granular zones of retinal necrosis, variable degrees of associated hemorrhage, and low-grade iritis and vitritis. Differential diagnosis is aided by characteristic features of CMV retinitis and other AIDS-related retinopathies. Initial treatment with ganciclovir or foscarnet has been found to stabilize retinitis, and maintenance therapy with either has been shown to prolong the time to retinitis progression. Further studies should help to determine the optimal approach to treatment of the disease.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antiviral Agents - therapeutic use</subject><subject>cytomegalovirus</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - drug therapy</subject><subject>Cytomegalovirus Infections - pathology</subject><subject>Drugs</subject><subject>Eye Infections, Viral - drug therapy</subject><subject>Eye Infections, Viral - etiology</subject><subject>Eye Infections, Viral - pathology</subject><subject>Eyes & eyesight</subject><subject>Foscarnet</subject><subject>Ganciclovir - therapeutic use</subject><subject>Health care</subject><subject>Humans</subject><subject>Infections</subject><subject>Phosphonoacetic Acid - analogs & derivatives</subject><subject>Phosphonoacetic Acid - therapeutic use</subject><subject>Retina - pathology</subject><subject>Retinitis - drug therapy</subject><subject>Retinitis - etiology</subject><subject>Retinitis - pathology</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKtvCPwDJ4oDKIWVsx05yqYRWtFSqxKWcjWNPWlebeGs7i_bf47AVSD3Q08h-34w97xHyjsEZA6Y-AwCvOlGL045_6kAIVskXZMWklFXDFH9JVn-R1-Q4pftyhE6qI3LEBAPZwIr8XN-ZaGzG6FP2NtEwULvPYcRbswk7H-dEI2Y_-ewT9RPdmuxxyon-8vmOGvsw-4iO-nGcp-Bw8LbIdk_TfnKxjHlDXg1mk_DtYz0hPy6-3qy_VdffL6_WX64rWzOZK4OoakBuyx4C2g6F7c2gWuesa2zvLChlymXNsXd8YLyVPajBDY3oDVdGnJCPh7nbGB5mTFmPPlncbMyEYU664S00TMCzIFNtzRWvC_jhCXgf5jiVJTQXvHyyBlmg-gDZGFKKOOht9KOJe81ALzHpJQO9ZKC7UpeY9NL2_nH23I_o_jUdcin6-UHHYtnOY9Tpj6_oits2axf8_x_4DaCMo7o</recordid><startdate>19920214</startdate><enddate>19920214</enddate><creator>Heinemann, Murk-Hein</creator><general>Elsevier Inc</general><general>Elsevier Sequoia S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19920214</creationdate><title>Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome</title><author>Heinemann, Murk-Hein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-aee640e2c0333089e3cbaf68ddcd7cbdc066ae3c42ebd2f1285b06fdf73ba26a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antiviral Agents - therapeutic use</topic><topic>cytomegalovirus</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - drug therapy</topic><topic>Cytomegalovirus Infections - pathology</topic><topic>Drugs</topic><topic>Eye Infections, Viral - drug therapy</topic><topic>Eye Infections, Viral - etiology</topic><topic>Eye Infections, Viral - pathology</topic><topic>Eyes & eyesight</topic><topic>Foscarnet</topic><topic>Ganciclovir - therapeutic use</topic><topic>Health care</topic><topic>Humans</topic><topic>Infections</topic><topic>Phosphonoacetic Acid - analogs & derivatives</topic><topic>Phosphonoacetic Acid - therapeutic use</topic><topic>Retina - pathology</topic><topic>Retinitis - drug therapy</topic><topic>Retinitis - etiology</topic><topic>Retinitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heinemann, Murk-Hein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - 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The disease is inexorably progressive when untreated, making early detection and prompt treatment essential for preservation of functional vision. The retinitis tends to be unilateral at presentation but often becomes bilateral as it progresses. Lesions may be unifocal or multifocal and may appear in the posterior retina or peripheral retina. Primary ophthalmoscopic features of CMV retinitis include white granular zones of retinal necrosis, variable degrees of associated hemorrhage, and low-grade iritis and vitritis. Differential diagnosis is aided by characteristic features of CMV retinitis and other AIDS-related retinopathies. Initial treatment with ganciclovir or foscarnet has been found to stabilize retinitis, and maintenance therapy with either has been shown to prolong the time to retinitis progression. Further studies should help to determine the optimal approach to treatment of the disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1310570</pmid><doi>10.1016/0002-9343(92)90331-5</doi></addata></record> |
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| ispartof | The American journal of medicine, 1992-02, Vol.92 (2), p.S12-S16 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications AIDS AIDS/HIV Antiviral Agents - therapeutic use cytomegalovirus Cytomegalovirus Infections - complications Cytomegalovirus Infections - drug therapy Cytomegalovirus Infections - pathology Drugs Eye Infections, Viral - drug therapy Eye Infections, Viral - etiology Eye Infections, Viral - pathology Eyes & eyesight Foscarnet Ganciclovir - therapeutic use Health care Humans Infections Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - therapeutic use Retina - pathology Retinitis - drug therapy Retinitis - etiology Retinitis - pathology |
| title | Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome |
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