Tissue ingrowth into titanium and hydroxyapatite-coated implants during stable and unstable mechanical conditions

Lack of initial mechanical stability of cementless prostheses may be responsible for fibrous tissue fixation of prosthetic components to bone. To study the influence of micromovements on bony ingrowth into titanium alloy (Ti) and hydroxyapatite (HA)‐coated implants, a loaded unstable device producin...

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Veröffentlicht in:Journal of orthopaedic research 1992-03, Vol.10 (2), p.285-299
Hauptverfasser: Søballe, Kjeld, Hansen, Ebbe S., B.-Rasmussen, Helle, Jørgensen, Peter H., Bünger, Code
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container_end_page 299
container_issue 2
container_start_page 285
container_title Journal of orthopaedic research
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creator Søballe, Kjeld
Hansen, Ebbe S.
B.-Rasmussen, Helle
Jørgensen, Peter H.
Bünger, Code
description Lack of initial mechanical stability of cementless prostheses may be responsible for fibrous tissue fixation of prosthetic components to bone. To study the influence of micromovements on bony ingrowth into titanium alloy (Ti) and hydroxyapatite (HA)‐coated implants, a loaded unstable device producing movements of 500 μm during each gait cycle was developed. Mechanically stable implants served as controls. The implants were inserted into the weight‐bearing regions of all four femoral condyles in each of seven mature dogs. Histological analysis after 4 weeks of implantation showed a fibrous tissue membrane surrounding both Ti and HA‐coated implants subjected to micromovements, whereas variable amounts of bony ingrowth were obtained in mechanically stable implants. The pushout test showed that the shear strength of unstable Ti and HA implants was significantly reduced as compared with the corresponding mechanically stable implants (p < 0.01). However, shear strength values of unstable HA‐coated implants were significantly greater than those of unstable Ti implants (p < 0.01) and comparable to those of stable Ti implants. The greatest shear strength was obtained with stable HA‐coated implants, which was threefold stronger as compared with the stable Ti implants (p < 0.001). Quantitative determination of bony ingrowth agreed with the mechanical test except for the stronger anchorage of unstable HA implants as compared with unstable Ti implants, where no difference in bony ingrowth was found. Unstable HA‐coated implants were surrounded by a fibrous membrane containing islands of fibrocartilage with higher collagen concentration, whereas fibrous connective tissue with lower collagen concentration was predominant around unstable Ti implants. In conclusion, micromovements between bone and implant inhibited bony ingrowth and led to the development of a fibrous membrane. The presence of fibrocartilage and a higher collagen concentration in the fibrous membrane may be responsible for the increased shear strength of unstable HA implants. Mechanically stable implants with HA coating had the strongest anchorage and the greatest amount of bony ingrowth.
doi_str_mv 10.1002/jor.1100100216
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To study the influence of micromovements on bony ingrowth into titanium alloy (Ti) and hydroxyapatite (HA)‐coated implants, a loaded unstable device producing movements of 500 μm during each gait cycle was developed. Mechanically stable implants served as controls. The implants were inserted into the weight‐bearing regions of all four femoral condyles in each of seven mature dogs. Histological analysis after 4 weeks of implantation showed a fibrous tissue membrane surrounding both Ti and HA‐coated implants subjected to micromovements, whereas variable amounts of bony ingrowth were obtained in mechanically stable implants. The pushout test showed that the shear strength of unstable Ti and HA implants was significantly reduced as compared with the corresponding mechanically stable implants (p &lt; 0.01). However, shear strength values of unstable HA‐coated implants were significantly greater than those of unstable Ti implants (p &lt; 0.01) and comparable to those of stable Ti implants. The greatest shear strength was obtained with stable HA‐coated implants, which was threefold stronger as compared with the stable Ti implants (p &lt; 0.001). Quantitative determination of bony ingrowth agreed with the mechanical test except for the stronger anchorage of unstable HA implants as compared with unstable Ti implants, where no difference in bony ingrowth was found. Unstable HA‐coated implants were surrounded by a fibrous membrane containing islands of fibrocartilage with higher collagen concentration, whereas fibrous connective tissue with lower collagen concentration was predominant around unstable Ti implants. In conclusion, micromovements between bone and implant inhibited bony ingrowth and led to the development of a fibrous membrane. The presence of fibrocartilage and a higher collagen concentration in the fibrous membrane may be responsible for the increased shear strength of unstable HA implants. 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Psychology ; Hydroxyapatite ; Hydroxyapatites ; Hydroxyproline - analysis ; Joint Instability - pathology ; Joint Instability - physiopathology ; Joint Prosthesis ; Knee Joint - pathology ; Knee Joint - physiology ; Knee Joint - surgery ; Micromotion ; Movement ; Porous ingrowth ; Prosthesis Design ; Prosthesis Failure ; Skeleton and joints ; Titanium ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of orthopaedic research, 1992-03, Vol.10 (2), p.285-299</ispartof><rights>Copyright © 1992 Orthopaedic Research Society</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4476-dba85d1c2356cb06bd62cbcf71865bfc802c3bad7dad7c176f7da8c215df4b773</citedby><cites>FETCH-LOGICAL-c4476-dba85d1c2356cb06bd62cbcf71865bfc802c3bad7dad7c176f7da8c215df4b773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjor.1100100216$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjor.1100100216$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=5275692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1311039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Søballe, Kjeld</creatorcontrib><creatorcontrib>Hansen, Ebbe S.</creatorcontrib><creatorcontrib>B.-Rasmussen, Helle</creatorcontrib><creatorcontrib>Jørgensen, Peter H.</creatorcontrib><creatorcontrib>Bünger, Code</creatorcontrib><title>Tissue ingrowth into titanium and hydroxyapatite-coated implants during stable and unstable mechanical conditions</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>Lack of initial mechanical stability of cementless prostheses may be responsible for fibrous tissue fixation of prosthetic components to bone. To study the influence of micromovements on bony ingrowth into titanium alloy (Ti) and hydroxyapatite (HA)‐coated implants, a loaded unstable device producing movements of 500 μm during each gait cycle was developed. Mechanically stable implants served as controls. The implants were inserted into the weight‐bearing regions of all four femoral condyles in each of seven mature dogs. Histological analysis after 4 weeks of implantation showed a fibrous tissue membrane surrounding both Ti and HA‐coated implants subjected to micromovements, whereas variable amounts of bony ingrowth were obtained in mechanically stable implants. The pushout test showed that the shear strength of unstable Ti and HA implants was significantly reduced as compared with the corresponding mechanically stable implants (p &lt; 0.01). 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Psychology</subject><subject>Hydroxyapatite</subject><subject>Hydroxyapatites</subject><subject>Hydroxyproline - analysis</subject><subject>Joint Instability - pathology</subject><subject>Joint Instability - physiopathology</subject><subject>Joint Prosthesis</subject><subject>Knee Joint - pathology</subject><subject>Knee Joint - physiology</subject><subject>Knee Joint - surgery</subject><subject>Micromotion</subject><subject>Movement</subject><subject>Porous ingrowth</subject><subject>Prosthesis Design</subject><subject>Prosthesis Failure</subject><subject>Skeleton and joints</subject><subject>Titanium</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUUtPxCAYJEaj6-PqzaQH460r0ALdo9n4zKqJ0eiN8KqLtmUFGt1_L9qNxpMHwnx8M8PHAMA-gmMEIT5-cX6MEvoqEF0DI0RImRPMntbBCLKC5hBTugW2Q3iBEDKEq02wiYqkKSYj8HZvQ-hNZrtn797jPIHosmij6GzfZqLT2XypvftYioVIxyZXTkSjM9suGtHFkOneJ3EWopCN-Rb03apojZonHyWaTLlO22hdF3bBRi2aYPZW-w54ODu9n17ks9vzy-nJLFdlyWiupaiIRgoXhCoJqdQUK6lqhipKZK0qiFUhhWY6LYUYrROqFEZE16VkrNgBR4Pvwru33oTIWxuUadLUxvWBM1xBBstJIo4HovIuBG9qvvC2FX7JEeRfsfKUMf_NOAkOVs69bI3-pQ-hpv7hqi9CenvtRads-KGlvyF0ghNtMtDebWOW_1zKr27v_oyQD1obovn40Qr_yikrGOGPN-f8Ec6e8M30mlfFJ5REp60</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>Søballe, Kjeld</creator><creator>Hansen, Ebbe S.</creator><creator>B.-Rasmussen, Helle</creator><creator>Jørgensen, Peter H.</creator><creator>Bünger, Code</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199203</creationdate><title>Tissue ingrowth into titanium and hydroxyapatite-coated implants during stable and unstable mechanical conditions</title><author>Søballe, Kjeld ; Hansen, Ebbe S. ; B.-Rasmussen, Helle ; Jørgensen, Peter H. ; Bünger, Code</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4476-dba85d1c2356cb06bd62cbcf71865bfc802c3bad7dad7c176f7da8c215df4b773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Bone ingrowth</topic><topic>Connective Tissue - pathology</topic><topic>Connective Tissue - physiology</topic><topic>Dogs</topic><topic>Durapatite</topic><topic>Femur - pathology</topic><topic>Femur - physiology</topic><topic>Femur - surgery</topic><topic>Fibrous membrane</topic><topic>Fundamental and applied biological sciences. 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Orthop. Res</addtitle><date>1992-03</date><risdate>1992</risdate><volume>10</volume><issue>2</issue><spage>285</spage><epage>299</epage><pages>285-299</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><coden>JOREDR</coden><abstract>Lack of initial mechanical stability of cementless prostheses may be responsible for fibrous tissue fixation of prosthetic components to bone. To study the influence of micromovements on bony ingrowth into titanium alloy (Ti) and hydroxyapatite (HA)‐coated implants, a loaded unstable device producing movements of 500 μm during each gait cycle was developed. Mechanically stable implants served as controls. The implants were inserted into the weight‐bearing regions of all four femoral condyles in each of seven mature dogs. Histological analysis after 4 weeks of implantation showed a fibrous tissue membrane surrounding both Ti and HA‐coated implants subjected to micromovements, whereas variable amounts of bony ingrowth were obtained in mechanically stable implants. The pushout test showed that the shear strength of unstable Ti and HA implants was significantly reduced as compared with the corresponding mechanically stable implants (p &lt; 0.01). However, shear strength values of unstable HA‐coated implants were significantly greater than those of unstable Ti implants (p &lt; 0.01) and comparable to those of stable Ti implants. The greatest shear strength was obtained with stable HA‐coated implants, which was threefold stronger as compared with the stable Ti implants (p &lt; 0.001). Quantitative determination of bony ingrowth agreed with the mechanical test except for the stronger anchorage of unstable HA implants as compared with unstable Ti implants, where no difference in bony ingrowth was found. Unstable HA‐coated implants were surrounded by a fibrous membrane containing islands of fibrocartilage with higher collagen concentration, whereas fibrous connective tissue with lower collagen concentration was predominant around unstable Ti implants. In conclusion, micromovements between bone and implant inhibited bony ingrowth and led to the development of a fibrous membrane. The presence of fibrocartilage and a higher collagen concentration in the fibrous membrane may be responsible for the increased shear strength of unstable HA implants. Mechanically stable implants with HA coating had the strongest anchorage and the greatest amount of bony ingrowth.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1311039</pmid><doi>10.1002/jor.1100100216</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record>
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subjects Analysis of Variance
Animals
Biological and medical sciences
Biomechanical Phenomena
Bone ingrowth
Connective Tissue - pathology
Connective Tissue - physiology
Dogs
Durapatite
Femur - pathology
Femur - physiology
Femur - surgery
Fibrous membrane
Fundamental and applied biological sciences. Psychology
Hydroxyapatite
Hydroxyapatites
Hydroxyproline - analysis
Joint Instability - pathology
Joint Instability - physiopathology
Joint Prosthesis
Knee Joint - pathology
Knee Joint - physiology
Knee Joint - surgery
Micromotion
Movement
Porous ingrowth
Prosthesis Design
Prosthesis Failure
Skeleton and joints
Titanium
Vertebrates: osteoarticular system, musculoskeletal system
title Tissue ingrowth into titanium and hydroxyapatite-coated implants during stable and unstable mechanical conditions
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