Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves
This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of IgG concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a referen...
Gespeichert in:
| Veröffentlicht in: | Mammalian genome 2002-12, Vol.13 (12), p.704-710 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 710 |
|---|---|
| container_issue | 12 |
| container_start_page | 704 |
| container_title | Mammalian genome |
| container_volume | 13 |
| creator | Laegreid, William W Heaton, Michael P Keen, James E Grosse, William M Chitko-McKown, Carol G Smith, Timothy P L Keele, John W Bennett, Gary L Besser, Thomas E |
| description | This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of IgG concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population. These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study. This study established that dams with FCGRT haplotype 3 had a significantly greater risk of failure of passive transfer in their calves (odds ratio [OR] = 3.80, CI95% 1.10-13.18, p = 0.035). Calves with FCGRT haplotype 2 were less likely to have high levels of passively acquired immunoglobulin (OR = 0.18, CI95% 0.05-0.68, p = 0.011). These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality. |
| doi_str_mv | 10.1007/s00335-002-2219-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72806179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72806179</sourcerecordid><originalsourceid>FETCH-LOGICAL-p207t-92605388548269c758987edb70fdb83e3905f0c9939c9235e211b3359a6b53dc3</originalsourceid><addsrcrecordid>eNo1kLFOwzAURT2AaCl8AAvyhGAIPNtNbI9VRUulSkiozJHjvDRBiR3ipFUH_p1Iheku517pHkLuGDwzAPkSAISIIwAecc50dLogU9BCRUprmJDrEL4AmEyYvCITxmM2l3M9JT-LELytTF95R31BM3-oHFKH3pne1HRlaYcW29531NRtaSJbmsrRPY7U42q5_tg90dK0te9PLQZ6rPqSBuyGhm72a2q9s-j67rw_9hweM985ak19wHBDLgtTB7z9yxn5XL3ulm_R9n29WS62UctB9pHmCcRCqXiueKKtjJVWEvNMQpFnSqDQEBdgtRbaai5i5Ixlow1tkiwWuRUz8nDebTv_PWDo06YKFuvajEeHkEquYDSjR_D-DxyyBvO07arGdKf0X5j4BbuLa9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72806179</pqid></control><display><type>article</type><title>Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Laegreid, William W ; Heaton, Michael P ; Keen, James E ; Grosse, William M ; Chitko-McKown, Carol G ; Smith, Timothy P L ; Keele, John W ; Bennett, Gary L ; Besser, Thomas E</creator><creatorcontrib>Laegreid, William W ; Heaton, Michael P ; Keen, James E ; Grosse, William M ; Chitko-McKown, Carol G ; Smith, Timothy P L ; Keele, John W ; Bennett, Gary L ; Besser, Thomas E</creatorcontrib><description>This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of IgG concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population. These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study. This study established that dams with FCGRT haplotype 3 had a significantly greater risk of failure of passive transfer in their calves (odds ratio [OR] = 3.80, CI95% 1.10-13.18, p = 0.035). Calves with FCGRT haplotype 2 were less likely to have high levels of passively acquired immunoglobulin (OR = 0.18, CI95% 0.05-0.68, p = 0.011). These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality.</description><identifier>ISSN: 0938-8990</identifier><identifier>DOI: 10.1007/s00335-002-2219-y</identifier><identifier>PMID: 12514749</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Animals, Newborn - immunology ; Antigens, CD - genetics ; Breeding ; Cattle ; Chromosome Mapping ; Chromosome Segregation ; Female ; Genotype ; Haplotypes ; Histocompatibility Antigens Class I ; Immunity, Maternally-Acquired ; Immunoglobulin G - blood ; Linkage Disequilibrium ; Male ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Receptors, Fc - genetics ; Risk Factors ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><ispartof>Mammalian genome, 2002-12, Vol.13 (12), p.704-710</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12514749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laegreid, William W</creatorcontrib><creatorcontrib>Heaton, Michael P</creatorcontrib><creatorcontrib>Keen, James E</creatorcontrib><creatorcontrib>Grosse, William M</creatorcontrib><creatorcontrib>Chitko-McKown, Carol G</creatorcontrib><creatorcontrib>Smith, Timothy P L</creatorcontrib><creatorcontrib>Keele, John W</creatorcontrib><creatorcontrib>Bennett, Gary L</creatorcontrib><creatorcontrib>Besser, Thomas E</creatorcontrib><title>Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves</title><title>Mammalian genome</title><addtitle>Mamm Genome</addtitle><description>This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of IgG concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population. These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study. This study established that dams with FCGRT haplotype 3 had a significantly greater risk of failure of passive transfer in their calves (odds ratio [OR] = 3.80, CI95% 1.10-13.18, p = 0.035). Calves with FCGRT haplotype 2 were less likely to have high levels of passively acquired immunoglobulin (OR = 0.18, CI95% 0.05-0.68, p = 0.011). These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality.</description><subject>Animals</subject><subject>Animals, Newborn - immunology</subject><subject>Antigens, CD - genetics</subject><subject>Breeding</subject><subject>Cattle</subject><subject>Chromosome Mapping</subject><subject>Chromosome Segregation</subject><subject>Female</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Histocompatibility Antigens Class I</subject><subject>Immunity, Maternally-Acquired</subject><subject>Immunoglobulin G - blood</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Fc - genetics</subject><subject>Risk Factors</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><issn>0938-8990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLFOwzAURT2AaCl8AAvyhGAIPNtNbI9VRUulSkiozJHjvDRBiR3ipFUH_p1Iheku517pHkLuGDwzAPkSAISIIwAecc50dLogU9BCRUprmJDrEL4AmEyYvCITxmM2l3M9JT-LELytTF95R31BM3-oHFKH3pne1HRlaYcW29531NRtaSJbmsrRPY7U42q5_tg90dK0te9PLQZ6rPqSBuyGhm72a2q9s-j67rw_9hweM985ak19wHBDLgtTB7z9yxn5XL3ulm_R9n29WS62UctB9pHmCcRCqXiueKKtjJVWEvNMQpFnSqDQEBdgtRbaai5i5Ixlow1tkiwWuRUz8nDebTv_PWDo06YKFuvajEeHkEquYDSjR_D-DxyyBvO07arGdKf0X5j4BbuLa9A</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Laegreid, William W</creator><creator>Heaton, Michael P</creator><creator>Keen, James E</creator><creator>Grosse, William M</creator><creator>Chitko-McKown, Carol G</creator><creator>Smith, Timothy P L</creator><creator>Keele, John W</creator><creator>Bennett, Gary L</creator><creator>Besser, Thomas E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves</title><author>Laegreid, William W ; Heaton, Michael P ; Keen, James E ; Grosse, William M ; Chitko-McKown, Carol G ; Smith, Timothy P L ; Keele, John W ; Bennett, Gary L ; Besser, Thomas E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-92605388548269c758987edb70fdb83e3905f0c9939c9235e211b3359a6b53dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Animals, Newborn - immunology</topic><topic>Antigens, CD - genetics</topic><topic>Breeding</topic><topic>Cattle</topic><topic>Chromosome Mapping</topic><topic>Chromosome Segregation</topic><topic>Female</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Histocompatibility Antigens Class I</topic><topic>Immunity, Maternally-Acquired</topic><topic>Immunoglobulin G - blood</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Fc - genetics</topic><topic>Risk Factors</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laegreid, William W</creatorcontrib><creatorcontrib>Heaton, Michael P</creatorcontrib><creatorcontrib>Keen, James E</creatorcontrib><creatorcontrib>Grosse, William M</creatorcontrib><creatorcontrib>Chitko-McKown, Carol G</creatorcontrib><creatorcontrib>Smith, Timothy P L</creatorcontrib><creatorcontrib>Keele, John W</creatorcontrib><creatorcontrib>Bennett, Gary L</creatorcontrib><creatorcontrib>Besser, Thomas E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Mammalian genome</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laegreid, William W</au><au>Heaton, Michael P</au><au>Keen, James E</au><au>Grosse, William M</au><au>Chitko-McKown, Carol G</au><au>Smith, Timothy P L</au><au>Keele, John W</au><au>Bennett, Gary L</au><au>Besser, Thomas E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves</atitle><jtitle>Mammalian genome</jtitle><addtitle>Mamm Genome</addtitle><date>2002-12</date><risdate>2002</risdate><volume>13</volume><issue>12</issue><spage>704</spage><epage>710</epage><pages>704-710</pages><issn>0938-8990</issn><abstract>This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of IgG concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population. These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study. This study established that dams with FCGRT haplotype 3 had a significantly greater risk of failure of passive transfer in their calves (odds ratio [OR] = 3.80, CI95% 1.10-13.18, p = 0.035). Calves with FCGRT haplotype 2 were less likely to have high levels of passively acquired immunoglobulin (OR = 0.18, CI95% 0.05-0.68, p = 0.011). These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality.</abstract><cop>United States</cop><pmid>12514749</pmid><doi>10.1007/s00335-002-2219-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-8990 |
| ispartof | Mammalian genome, 2002-12, Vol.13 (12), p.704-710 |
| issn | 0938-8990 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72806179 |
| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Animals Animals, Newborn - immunology Antigens, CD - genetics Breeding Cattle Chromosome Mapping Chromosome Segregation Female Genotype Haplotypes Histocompatibility Antigens Class I Immunity, Maternally-Acquired Immunoglobulin G - blood Linkage Disequilibrium Male Polymerase Chain Reaction Polymorphism, Single Nucleotide Receptors, Fc - genetics Risk Factors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| title | Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A51%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20bovine%20neonatal%20Fc%20receptor%20alpha-chain%20gene%20(FCGRT)%20haplotypes%20with%20serum%20IgG%20concentration%20in%20newborn%20calves&rft.jtitle=Mammalian%20genome&rft.au=Laegreid,%20William%20W&rft.date=2002-12&rft.volume=13&rft.issue=12&rft.spage=704&rft.epage=710&rft.pages=704-710&rft.issn=0938-8990&rft_id=info:doi/10.1007/s00335-002-2219-y&rft_dat=%3Cproquest_pubme%3E72806179%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72806179&rft_id=info:pmid/12514749&rfr_iscdi=true |