Effect of Signal Interference from Dosing Excipients on Pharmacokinetic Screening of Drug Candidates by Liquid Chromatography/Mass Spectrometry

The effect of dosing vehicle excipients such as PEG400, propylene glycol, Tween 80, and hydroxypropyl-β-cyclodextrin on the accuracy of LC/MS measurements used in pharmacokinetic studies is examined. Using PEG400 as a probe compound, the concentration−time profile of the excipient in plasma from rat...

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Veröffentlicht in:	Analytical chemistry (Washington) 2002-12, Vol.74 (24), p.6305-6313
Hauptverfasser:	Tong, Xinchun S, Wang, Junying, Zheng, Song, Pivnichny, James V, Griffin, Patrick R, Shen, Xiaolan, Donnelly, Marcie, Vakerich, Ken, Nunes, Chris, Fenyk-Melody, Judy
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Chemistry Chromatography Chromatography, Liquid - methods Drug Evaluation, Preclinical Excipients - administration & dosage Excipients - analysis Excipients - pharmacokinetics General pharmacology Injections, Intravenous Male Mass Spectrometry - methods Medical sciences Medical screening Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - blood Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polyethylene Glycols - administration & dosage Polyethylene Glycols - analysis Polyethylene Glycols - pharmacokinetics Rats Rats, Sprague-Dawley Scientific imaging Sensitivity and Specificity
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