Endocannabinoids and related fatty acid derivatives in pain modulation
The brain produces at least five compounds that possess sub-micromolar affinity for cannabinoid receptors: anandamide, 2-arachidonoylglycerol, noladin ether, virodhamine, and N-arachidonoyldopamine (NADA). One function of these and/or related compounds is to suppress pain sensitivity. Much evidence...
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| Veröffentlicht in: | Chemistry and Physics of Lipids 2002-12, Vol.121 (1), p.159-172 |
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| container_title | Chemistry and Physics of Lipids |
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| creator | Walker, J.Michael Krey, Jocelyn F. Chu, Constance J. Huang, Susan M. |
| description | The brain produces at least five compounds that possess sub-micromolar affinity for cannabinoid receptors: anandamide, 2-arachidonoylglycerol, noladin ether, virodhamine, and
N-arachidonoyldopamine (NADA). One function of these and/or related compounds is to suppress pain sensitivity. Much evidence supports a role of endocannabinoids in pain modulation in general, and some evidence points to the role of particular endocannabinoids. Related endogenous fatty acid derivatives such as oleamide, palmitoylethanolamide, 2-lineoylglycerol, 2-palmitoylglycerol, and a family of arachidonoyl amino acids may interact with endocannabinoids in the modulation of pain sensitivity. |
| doi_str_mv | 10.1016/S0009-3084(02)00152-4 |
| format | Article |
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N-arachidonoyldopamine (NADA). One function of these and/or related compounds is to suppress pain sensitivity. Much evidence supports a role of endocannabinoids in pain modulation in general, and some evidence points to the role of particular endocannabinoids. Related endogenous fatty acid derivatives such as oleamide, palmitoylethanolamide, 2-lineoylglycerol, 2-palmitoylglycerol, and a family of arachidonoyl amino acids may interact with endocannabinoids in the modulation of pain sensitivity.</description><identifier>ISSN: 0009-3084</identifier><identifier>EISSN: 1873-2941</identifier><identifier>DOI: 10.1016/S0009-3084(02)00152-4</identifier><identifier>PMID: 12505698</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Analgesia ; Anandamide ; Animals ; Biomarkers ; Cannabinoid ; Cannabinoid Receptor Modulators ; Endocannabinoid ; Endocannabinoids ; Fatty Acids - chemistry ; Fatty Acids - metabolism ; Fatty Acids - pharmacology ; Fatty Acids, Unsaturated - chemistry ; Fatty Acids, Unsaturated - metabolism ; Fatty Acids, Unsaturated - pharmacology ; Humans ; Nervous System - metabolism ; Pain ; Pain - metabolism ; Receptor ; Receptors, Cannabinoid ; Receptors, Drug - metabolism</subject><ispartof>Chemistry and Physics of Lipids, 2002-12, Vol.121 (1), p.159-172</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-ab5f384d110928403513516cab2105cd215745cda49826ef5a417423e5d4d0f3</citedby><cites>FETCH-LOGICAL-c479t-ab5f384d110928403513516cab2105cd215745cda49826ef5a417423e5d4d0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0009-3084(02)00152-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3548,27921,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12505698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, J.Michael</creatorcontrib><creatorcontrib>Krey, Jocelyn F.</creatorcontrib><creatorcontrib>Chu, Constance J.</creatorcontrib><creatorcontrib>Huang, Susan M.</creatorcontrib><title>Endocannabinoids and related fatty acid derivatives in pain modulation</title><title>Chemistry and Physics of Lipids</title><addtitle>Chem Phys Lipids</addtitle><description>The brain produces at least five compounds that possess sub-micromolar affinity for cannabinoid receptors: anandamide, 2-arachidonoylglycerol, noladin ether, virodhamine, and
N-arachidonoyldopamine (NADA). One function of these and/or related compounds is to suppress pain sensitivity. Much evidence supports a role of endocannabinoids in pain modulation in general, and some evidence points to the role of particular endocannabinoids. Related endogenous fatty acid derivatives such as oleamide, palmitoylethanolamide, 2-lineoylglycerol, 2-palmitoylglycerol, and a family of arachidonoyl amino acids may interact with endocannabinoids in the modulation of pain sensitivity.</description><subject>Analgesia</subject><subject>Anandamide</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Cannabinoid</subject><subject>Cannabinoid Receptor Modulators</subject><subject>Endocannabinoid</subject><subject>Endocannabinoids</subject><subject>Fatty Acids - chemistry</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids - pharmacology</subject><subject>Fatty Acids, Unsaturated - chemistry</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Fatty Acids, Unsaturated - pharmacology</subject><subject>Humans</subject><subject>Nervous System - metabolism</subject><subject>Pain</subject><subject>Pain - metabolism</subject><subject>Receptor</subject><subject>Receptors, Cannabinoid</subject><subject>Receptors, Drug - metabolism</subject><issn>0009-3084</issn><issn>1873-2941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7rr6E5SeRA_VSZr0cRJZ1gcseHDvIU2mEGnTNWkX9t-bfaBHYZhh4JsZ5iPkmsIDBZo_fgJAlWZQ8jtg9wBUsJSfkCktiyxlFaenZPqLTMhFCF-xBSHoOZlQJkDkVTklLwtneq2cU7V1vTUhUc4kHls1oEkaNQzbRGlrEoPebtRgNxgS65K1iqnrzRhB27tLctaoNuDVsc7I6mWxmr-ly4_X9_nzMtW8qIZU1aLJSm4ohYqVHDJBY-Ra1YyC0IZRUfBYFa9KlmMjFKcFZxkKww002YzcHtauff89YhhkZ4PGtlUO-zHIgpUQ8SyC4gBq34fgsZFrbzvlt5KC3PmTe39yJ0cCk3t_kse5m-OBse7Q_E0dhUXg6QBg_HJj0cugLTqNxnrUgzS9_efED1ikfng</recordid><startdate>20021231</startdate><enddate>20021231</enddate><creator>Walker, J.Michael</creator><creator>Krey, Jocelyn F.</creator><creator>Chu, Constance J.</creator><creator>Huang, Susan M.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021231</creationdate><title>Endocannabinoids and related fatty acid derivatives in pain modulation</title><author>Walker, J.Michael ; Krey, Jocelyn F. ; Chu, Constance J. ; Huang, Susan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-ab5f384d110928403513516cab2105cd215745cda49826ef5a417423e5d4d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analgesia</topic><topic>Anandamide</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Cannabinoid</topic><topic>Cannabinoid Receptor Modulators</topic><topic>Endocannabinoid</topic><topic>Endocannabinoids</topic><topic>Fatty Acids - chemistry</topic><topic>Fatty Acids - metabolism</topic><topic>Fatty Acids - pharmacology</topic><topic>Fatty Acids, Unsaturated - chemistry</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Fatty Acids, Unsaturated - pharmacology</topic><topic>Humans</topic><topic>Nervous System - metabolism</topic><topic>Pain</topic><topic>Pain - metabolism</topic><topic>Receptor</topic><topic>Receptors, Cannabinoid</topic><topic>Receptors, Drug - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walker, J.Michael</creatorcontrib><creatorcontrib>Krey, Jocelyn F.</creatorcontrib><creatorcontrib>Chu, Constance J.</creatorcontrib><creatorcontrib>Huang, Susan M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry and Physics of Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walker, J.Michael</au><au>Krey, Jocelyn F.</au><au>Chu, Constance J.</au><au>Huang, Susan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocannabinoids and related fatty acid derivatives in pain modulation</atitle><jtitle>Chemistry and Physics of Lipids</jtitle><addtitle>Chem Phys Lipids</addtitle><date>2002-12-31</date><risdate>2002</risdate><volume>121</volume><issue>1</issue><spage>159</spage><epage>172</epage><pages>159-172</pages><issn>0009-3084</issn><eissn>1873-2941</eissn><abstract>The brain produces at least five compounds that possess sub-micromolar affinity for cannabinoid receptors: anandamide, 2-arachidonoylglycerol, noladin ether, virodhamine, and
N-arachidonoyldopamine (NADA). One function of these and/or related compounds is to suppress pain sensitivity. Much evidence supports a role of endocannabinoids in pain modulation in general, and some evidence points to the role of particular endocannabinoids. Related endogenous fatty acid derivatives such as oleamide, palmitoylethanolamide, 2-lineoylglycerol, 2-palmitoylglycerol, and a family of arachidonoyl amino acids may interact with endocannabinoids in the modulation of pain sensitivity.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>12505698</pmid><doi>10.1016/S0009-3084(02)00152-4</doi><tpages>14</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analgesia Anandamide Animals Biomarkers Cannabinoid Cannabinoid Receptor Modulators Endocannabinoid Endocannabinoids Fatty Acids - chemistry Fatty Acids - metabolism Fatty Acids - pharmacology Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - metabolism Fatty Acids, Unsaturated - pharmacology Humans Nervous System - metabolism Pain Pain - metabolism Receptor Receptors, Cannabinoid Receptors, Drug - metabolism |
| title | Endocannabinoids and related fatty acid derivatives in pain modulation |
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