A retrospective study of hyposensitization in canine atopy based on a polyclonal ELISA test
Compliance with the treatment protocol and the most significant reasons encountered in general practice for the discontinuation of treatment in hyposensitized dogs are examined. The data are based on (1) a review of order forms for the hyposenzitization mixture and information sheets for an ELISA te...
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Veröffentlicht in: | Veterinary research communications 2002-12, Vol.26 (8), p.613-624 |
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description | Compliance with the treatment protocol and the most significant reasons encountered in general practice for the discontinuation of treatment in hyposensitized dogs are examined. The data are based on (1) a review of order forms for the hyposenzitization mixture and information sheets for an ELISA test and (2) telephone interviews with dog owners. Most of the owners (81%) gave their dogs allergen injections at home. Non-compliance was defined as discontinuation of treatment in the induction period; 33.9% of the owners became non-compliant. A large proportion of non-compliant owners (51.2%) claimed to be unaware of the length of the induction period. Furthermore, 70.2% of the owners were not aware that treatment would most likely need to be lifelong if it was to remain effective. Although 67.5% of the owners perceived that their dogs had beneficial effects from hyposensitization, only 36.3% of the dogs were receiving maintenance injections at the time of the telephone interview, considerably reducing the long-term benefit from treatment. Canine atopy is a chronic disease characterized by remission and relapses. Since no control group was available in this study, the beneficial outcome of treatment reported by the owners could be partly due to the natural course of the disease. Nevertheless, the results indicated that the long-term effect of hyposensitization in canine atopy will be reduced by premature discontinuation of treatment in the maintenance period. The discontinuation of treatment could be a reflection of the treatment becoming less effective, owing to the development of new hypersensitivities or to a reduction in the placebo effect that may occur in 'new' treatments. However, poor client education and follow-up seem to be important reasons for both noncompliance and discontinuation of the treatment in the maintenance period. |
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The data are based on (1) a review of order forms for the hyposenzitization mixture and information sheets for an ELISA test and (2) telephone interviews with dog owners. Most of the owners (81%) gave their dogs allergen injections at home. Non-compliance was defined as discontinuation of treatment in the induction period; 33.9% of the owners became non-compliant. A large proportion of non-compliant owners (51.2%) claimed to be unaware of the length of the induction period. Furthermore, 70.2% of the owners were not aware that treatment would most likely need to be lifelong if it was to remain effective. Although 67.5% of the owners perceived that their dogs had beneficial effects from hyposensitization, only 36.3% of the dogs were receiving maintenance injections at the time of the telephone interview, considerably reducing the long-term benefit from treatment. Canine atopy is a chronic disease characterized by remission and relapses. Since no control group was available in this study, the beneficial outcome of treatment reported by the owners could be partly due to the natural course of the disease. Nevertheless, the results indicated that the long-term effect of hyposensitization in canine atopy will be reduced by premature discontinuation of treatment in the maintenance period. The discontinuation of treatment could be a reflection of the treatment becoming less effective, owing to the development of new hypersensitivities or to a reduction in the placebo effect that may occur in 'new' treatments. However, poor client education and follow-up seem to be important reasons for both noncompliance and discontinuation of the treatment in the maintenance period.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1023/A:1020968703929</identifier><identifier>PMID: 12507036</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Allergens - analysis ; Animals ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - prevention & control ; Dermatitis, Atopic - veterinary ; Desensitization, Immunologic - methods ; Desensitization, Immunologic - veterinary ; Dog Diseases - immunology ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Female ; Immunoglobulin E - blood ; Male ; Retrospective Studies ; Skin Tests - veterinary ; Surveys and Questionnaires ; Treatment Refusal</subject><ispartof>Veterinary research communications, 2002-12, Vol.26 (8), p.613-624</ispartof><rights>Copyright (c) 2002 Kluwer Academic Publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-7c6cd59cf35714a4cc5d0402adca66f3c64ab11629d80d4d1f73a6ec44ee4b413</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12507036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saevik, B K</creatorcontrib><creatorcontrib>Thoresen, S I</creatorcontrib><creatorcontrib>Kristensen, F</creatorcontrib><title>A retrospective study of hyposensitization in canine atopy based on a polyclonal ELISA test</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>Compliance with the treatment protocol and the most significant reasons encountered in general practice for the discontinuation of treatment in hyposensitized dogs are examined. The data are based on (1) a review of order forms for the hyposenzitization mixture and information sheets for an ELISA test and (2) telephone interviews with dog owners. Most of the owners (81%) gave their dogs allergen injections at home. Non-compliance was defined as discontinuation of treatment in the induction period; 33.9% of the owners became non-compliant. A large proportion of non-compliant owners (51.2%) claimed to be unaware of the length of the induction period. Furthermore, 70.2% of the owners were not aware that treatment would most likely need to be lifelong if it was to remain effective. Although 67.5% of the owners perceived that their dogs had beneficial effects from hyposensitization, only 36.3% of the dogs were receiving maintenance injections at the time of the telephone interview, considerably reducing the long-term benefit from treatment. Canine atopy is a chronic disease characterized by remission and relapses. Since no control group was available in this study, the beneficial outcome of treatment reported by the owners could be partly due to the natural course of the disease. Nevertheless, the results indicated that the long-term effect of hyposensitization in canine atopy will be reduced by premature discontinuation of treatment in the maintenance period. The discontinuation of treatment could be a reflection of the treatment becoming less effective, owing to the development of new hypersensitivities or to a reduction in the placebo effect that may occur in 'new' treatments. However, poor client education and follow-up seem to be important reasons for both noncompliance and discontinuation of the treatment in the maintenance period.</description><subject>Allergens - analysis</subject><subject>Animals</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - prevention & control</subject><subject>Dermatitis, Atopic - veterinary</subject><subject>Desensitization, Immunologic - methods</subject><subject>Desensitization, Immunologic - veterinary</subject><subject>Dog Diseases - immunology</subject><subject>Dogs</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Immunoglobulin E - blood</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Skin Tests - veterinary</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Refusal</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkL1PwzAUxC0EoqUwsyGLgS3w_BE7YYuqApUqMQATQ-TYjnCVxiF2KoW_niDKwnTD-7270yF0SeCWAGV3xf0kkItMAstpfoTmJJUskZyLYzQHItJEsgxm6CyELQDkGbBTNCM0helDzNF7gXsbex86q6PbWxziYEbsa_wxdj7YNrjovlR0vsWuxVq1rrVYRd-NuFLBGjwdFO58M-rGt6rBq836pcDRhniOTmrVBHtx0AV6e1i9Lp-SzfPjellsEk0ziInUQps01zVLJeGKa50a4ECV0UqImmnBVUWIoLnJwHBDasmUsJpza3nFCVugm1_frvefwxRc7lzQtmlUa_0QSjnFcCAwgdf_wK0f-ql0KCkFwiEVP25XB2iodtaUXe92qh_Lv83YNyOPbdc</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Saevik, B K</creator><creator>Thoresen, S I</creator><creator>Kristensen, F</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200212</creationdate><title>A retrospective study of hyposensitization in canine atopy based on a polyclonal ELISA test</title><author>Saevik, B K ; 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The data are based on (1) a review of order forms for the hyposenzitization mixture and information sheets for an ELISA test and (2) telephone interviews with dog owners. Most of the owners (81%) gave their dogs allergen injections at home. Non-compliance was defined as discontinuation of treatment in the induction period; 33.9% of the owners became non-compliant. A large proportion of non-compliant owners (51.2%) claimed to be unaware of the length of the induction period. Furthermore, 70.2% of the owners were not aware that treatment would most likely need to be lifelong if it was to remain effective. Although 67.5% of the owners perceived that their dogs had beneficial effects from hyposensitization, only 36.3% of the dogs were receiving maintenance injections at the time of the telephone interview, considerably reducing the long-term benefit from treatment. Canine atopy is a chronic disease characterized by remission and relapses. 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subjects | Allergens - analysis Animals Dermatitis, Atopic - blood Dermatitis, Atopic - immunology Dermatitis, Atopic - prevention & control Dermatitis, Atopic - veterinary Desensitization, Immunologic - methods Desensitization, Immunologic - veterinary Dog Diseases - immunology Dogs Enzyme-Linked Immunosorbent Assay Female Immunoglobulin E - blood Male Retrospective Studies Skin Tests - veterinary Surveys and Questionnaires Treatment Refusal |
title | A retrospective study of hyposensitization in canine atopy based on a polyclonal ELISA test |
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