NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation

Targeting of electron affinic radiosensitizers to DNA via reversible non-covalent intercalative binding has potential for increasing sensitizer concentrations locally at the DNA target while decreasing accessibility to reductases responsible for bioactivation and cytotoxicity. We have prepared an DN...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1992, Vol.22 (3), p.553-556
Hauptverfasser:	Denny, William A., Roberts, Peter B., Anderson, Robert F., Martin Brown, J., Wilson, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-nitroimidazole Acridine Aminoacridines - metabolism Aminoacridines - pharmacology Aminoacridines - therapeutic use Animals Biological and medical sciences Cell Hypoxia - drug effects Cell Hypoxia - physiology Cell Hypoxia - radiation effects Cell Line Combined Modality Therapy DNA - metabolism DNA intercalation DNA, Neoplasm - metabolism EMT6 HPLC Intercalating Agents - metabolism Intercalating Agents - pharmacology Intercalating Agents - therapeutic use Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Misonidazole Neoplasms, Experimental - drug therapy Neoplasms, Experimental - radiotherapy Nitroimidazoles - metabolism Nitroimidazoles - pharmacology Nitroimidazoles - therapeutic use NLA-1 Pimonidazole Radiation therapy and radiosensitizing agent Radiation-Sensitizing Agents - metabolism Radiation-Sensitizing Agents - pharmacology Radiation-Sensitizing Agents - therapeutic use SCCVII Treatment with physical agents Treatment. General aspects Tumors
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