Women's Angiographic Vitamin and Estrogen trial:: design and methods
The Women's Angiographic Vitamin and Estrogen trial was a randomized, double-blind, placebo-controlled study designed to test the efficacy of estrogen replacement and antioxidant vitamins for preventing angiographic progression of coronary artery disease. Postmenopausal women with one or more a...
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| Veröffentlicht in: | Controlled clinical trials 2002-12, Vol.23 (6), p.708-727 |
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| container_title | Controlled clinical trials |
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| creator | Hsia, Judith Alderman, Edwin L Verter, Joel I Rogers, William J Thompson, Paul Howard, Barbara V Cobb, Frederick R Ouyang, Pamela Tardif, Jean Claude Higginson, Lyall Bittner, Vera Barofsky, Ivan Steffes, Michael Gordon, David J Proschan, Michael Younes, Naji Waters, David |
| description | The Women's Angiographic Vitamin and Estrogen trial was a randomized, double-blind, placebo-controlled study designed to test the efficacy of estrogen replacement and antioxidant vitamins for preventing angiographic progression of coronary artery disease. Postmenopausal women with one or more angiographically documented coronary stenoses of 15–75% at baseline were assigned in a 2×2 factorial randomization to active hormone replacement therapy (conjugated estrogens for women who had had a hysterectomy or conjugated estrogens with medroxyprogesterone for women with intact uteri) or placebo and to active vitamins E and C or their placebos. Seven clinical centers, five in the United States and two in Canada, randomized 423 women between July 1997 and July 1999. Quantitative coronary angiography was performed at baseline and repeated after projected mean follow-up of 3 years. |
| doi_str_mv | 10.1016/S0197-2456(02)00237-4 |
| format | Article |
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Postmenopausal women with one or more angiographically documented coronary stenoses of 15–75% at baseline were assigned in a 2×2 factorial randomization to active hormone replacement therapy (conjugated estrogens for women who had had a hysterectomy or conjugated estrogens with medroxyprogesterone for women with intact uteri) or placebo and to active vitamins E and C or their placebos. Seven clinical centers, five in the United States and two in Canada, randomized 423 women between July 1997 and July 1999. Quantitative coronary angiography was performed at baseline and repeated after projected mean follow-up of 3 years.</description><identifier>ISSN: 0197-2456</identifier><identifier>EISSN: 1879-050X</identifier><identifier>DOI: 10.1016/S0197-2456(02)00237-4</identifier><identifier>PMID: 12505248</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antioxidants ; Antioxidants - therapeutic use ; Biological and medical sciences ; Canada ; Coronary Angiography ; Coronary Disease - prevention & control ; Coronary heart disease ; Endpoint Determination ; Estrogen ; Estrogen Replacement Therapy ; Female ; General and cellular metabolism. Vitamins ; Hormones. Endocrine system ; Humans ; Medical sciences ; Multicenter Studies as Topic ; Pharmacology. Drug treatments ; Randomized Controlled Trials as Topic - methods ; Randomized Controlled Trials as Topic - statistics & numerical data ; Research Design ; United States</subject><ispartof>Controlled clinical trials, 2002-12, Vol.23 (6), p.708-727</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14408141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12505248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsia, Judith</creatorcontrib><creatorcontrib>Alderman, Edwin L</creatorcontrib><creatorcontrib>Verter, Joel I</creatorcontrib><creatorcontrib>Rogers, William J</creatorcontrib><creatorcontrib>Thompson, Paul</creatorcontrib><creatorcontrib>Howard, Barbara V</creatorcontrib><creatorcontrib>Cobb, Frederick R</creatorcontrib><creatorcontrib>Ouyang, Pamela</creatorcontrib><creatorcontrib>Tardif, Jean Claude</creatorcontrib><creatorcontrib>Higginson, Lyall</creatorcontrib><creatorcontrib>Bittner, Vera</creatorcontrib><creatorcontrib>Barofsky, Ivan</creatorcontrib><creatorcontrib>Steffes, Michael</creatorcontrib><creatorcontrib>Gordon, David J</creatorcontrib><creatorcontrib>Proschan, Michael</creatorcontrib><creatorcontrib>Younes, Naji</creatorcontrib><creatorcontrib>Waters, David</creatorcontrib><title>Women's Angiographic Vitamin and Estrogen trial:: design and methods</title><title>Controlled clinical trials</title><addtitle>Control Clin Trials</addtitle><description>The Women's Angiographic Vitamin and Estrogen trial was a randomized, double-blind, placebo-controlled study designed to test the efficacy of estrogen replacement and antioxidant vitamins for preventing angiographic progression of coronary artery disease. Postmenopausal women with one or more angiographically documented coronary stenoses of 15–75% at baseline were assigned in a 2×2 factorial randomization to active hormone replacement therapy (conjugated estrogens for women who had had a hysterectomy or conjugated estrogens with medroxyprogesterone for women with intact uteri) or placebo and to active vitamins E and C or their placebos. Seven clinical centers, five in the United States and two in Canada, randomized 423 women between July 1997 and July 1999. Quantitative coronary angiography was performed at baseline and repeated after projected mean follow-up of 3 years.</description><subject>Antioxidants</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Canada</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - prevention & control</subject><subject>Coronary heart disease</subject><subject>Endpoint Determination</subject><subject>Estrogen</subject><subject>Estrogen Replacement Therapy</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Multicenter Studies as Topic</subject><subject>Pharmacology. 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| subjects | Antioxidants Antioxidants - therapeutic use Biological and medical sciences Canada Coronary Angiography Coronary Disease - prevention & control Coronary heart disease Endpoint Determination Estrogen Estrogen Replacement Therapy Female General and cellular metabolism. Vitamins Hormones. Endocrine system Humans Medical sciences Multicenter Studies as Topic Pharmacology. Drug treatments Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - statistics & numerical data Research Design United States |
| title | Women's Angiographic Vitamin and Estrogen trial:: design and methods |
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