Atypical t(15;17)(q13;q12) in a patient with all- trans retinoic acid refractory secondary acute promyelocytic leukemia: : a case report and review of the literature
A 69-year-old woman developed microgranular acute promyelocytic leukemia (APL-M3) 10 months after receiving adjuvant cyclophosphamide, doxorubicin, and paclitaxel for breast cancer. Replicate bone marrow aspirate karyotypes contained a translocation between the long arms of chromosomes 15 and 17, bu...
Gespeichert in:
| Veröffentlicht in: | Cancer genetics and cytogenetics 2002-10, Vol.138 (2), p.143-148 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 148 |
|---|---|
| container_issue | 2 |
| container_start_page | 143 |
| container_title | Cancer genetics and cytogenetics |
| container_volume | 138 |
| creator | Kurian, Sobha Hogan, Thomas F. Bleigh, Ona C. Dowdy, Yvonne G. Merghoub, Taha Pandolfi, Pier Paolo Wenger, Sharon L. |
| description | A 69-year-old woman developed microgranular acute promyelocytic leukemia (APL-M3) 10 months after receiving adjuvant cyclophosphamide, doxorubicin, and paclitaxel for breast cancer. Replicate bone marrow aspirate karyotypes contained a translocation between the long arms of chromosomes 15 and 17, but not at breakpoints typical for APL. Fluorescence in situ hybridization paints and RARα/PML cosmid probes verified that the breakpoints on chromosomes 15 and 17 were proximal to both the
PML and
RARα genes; t(15;17)(q13;12). Although the patient received induction chemotherapy and a several month trial of all-
trans retinoic acid (ATRA), there was no clinical improvement or hematological remission. We suspect that this patient developed postchemotherapy secondary APL with an atypical t(15;17), which rendered her leukemic cells unresponsive to ATRA therapy. |
| doi_str_mv | 10.1016/S0165-4608(02)00591-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72802536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165460802005915</els_id><sourcerecordid>72802536</sourcerecordid><originalsourceid>FETCH-LOGICAL-e293t-4fcc1876ac1b81a2425fc8634fbc1f3644e8b022819943b50fa01c74b1d322053</originalsourceid><addsrcrecordid>eNpFkUtv1DAUhS0EokPhJ4C8oZpZBK5fSaZdoKqigFSJBbC2bpwb1ZDX2A7V_CD-J552Chs_pM_n-pzD2GsB7wSI8v23vJhCl1CvQW4AzFYU5glbibpShdamfMpW_5AT9iLGnwBQyW35nJ0IacDIElbsz2Xaz95hz9NamAtRbdY7oS52Qm64HznyGZOnMfE7n2459n3BU8Ax8kDJj5N3HJ1v860L6NIU9jySm8YW8wndkojPYRr21E9unzLd0_KLBo_n_DyLO4yU385TSBzHg8xvT3d86ni6Jd77RAHTEugle9ZhH-nVcT9lP64_fr_6XNx8_fTl6vKmILlVqdCdc9l_iU40tUCppelcXSrdNU50qtSa6gakrMV2q1VjoEMQrtKNaJWUYNQpO3vQzZ_eLRSTHXx01Pc40rREW8kapFFlBt8cwaUZqLVz8EO2bB-DzcDbI4Axp5vTGZ2P_zmtRQ3qMPHDA0fZVjYfbHQ5b0etD-SSbSdvBdhD5fa-cnvo04K095Vbo_4CGuecJw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72802536</pqid></control><display><type>article</type><title>Atypical t(15;17)(q13;q12) in a patient with all- trans retinoic acid refractory secondary acute promyelocytic leukemia: : a case report and review of the literature</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Kurian, Sobha ; Hogan, Thomas F. ; Bleigh, Ona C. ; Dowdy, Yvonne G. ; Merghoub, Taha ; Pandolfi, Pier Paolo ; Wenger, Sharon L.</creator><creatorcontrib>Kurian, Sobha ; Hogan, Thomas F. ; Bleigh, Ona C. ; Dowdy, Yvonne G. ; Merghoub, Taha ; Pandolfi, Pier Paolo ; Wenger, Sharon L.</creatorcontrib><description>A 69-year-old woman developed microgranular acute promyelocytic leukemia (APL-M3) 10 months after receiving adjuvant cyclophosphamide, doxorubicin, and paclitaxel for breast cancer. Replicate bone marrow aspirate karyotypes contained a translocation between the long arms of chromosomes 15 and 17, but not at breakpoints typical for APL. Fluorescence in situ hybridization paints and RARα/PML cosmid probes verified that the breakpoints on chromosomes 15 and 17 were proximal to both the
PML and
RARα genes; t(15;17)(q13;12). Although the patient received induction chemotherapy and a several month trial of all-
trans retinoic acid (ATRA), there was no clinical improvement or hematological remission. We suspect that this patient developed postchemotherapy secondary APL with an atypical t(15;17), which rendered her leukemic cells unresponsive to ATRA therapy.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(02)00591-5</identifier><identifier>PMID: 12505260</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Bone Marrow - pathology ; Breast Neoplasms - complications ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Chromosome Breakage - genetics ; Chromosomes, Human, Pair 15 - genetics ; Chromosomes, Human, Pair 17 - genetics ; Drug Resistance, Neoplasm ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Leukemia, Promyelocytic, Acute - complications ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - genetics ; Medical sciences ; Pharmacology. Drug treatments ; Receptors, Retinoic Acid - genetics ; Receptors, Retinoic Acid - metabolism ; Retinoic Acid Receptor alpha ; Toxicity: blood ; Translocation, Genetic - genetics ; Tretinoin - pharmacology ; Tretinoin - therapeutic use</subject><ispartof>Cancer genetics and cytogenetics, 2002-10, Vol.138 (2), p.143-148</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-4608(02)00591-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14418035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12505260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurian, Sobha</creatorcontrib><creatorcontrib>Hogan, Thomas F.</creatorcontrib><creatorcontrib>Bleigh, Ona C.</creatorcontrib><creatorcontrib>Dowdy, Yvonne G.</creatorcontrib><creatorcontrib>Merghoub, Taha</creatorcontrib><creatorcontrib>Pandolfi, Pier Paolo</creatorcontrib><creatorcontrib>Wenger, Sharon L.</creatorcontrib><title>Atypical t(15;17)(q13;q12) in a patient with all- trans retinoic acid refractory secondary acute promyelocytic leukemia: : a case report and review of the literature</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>A 69-year-old woman developed microgranular acute promyelocytic leukemia (APL-M3) 10 months after receiving adjuvant cyclophosphamide, doxorubicin, and paclitaxel for breast cancer. Replicate bone marrow aspirate karyotypes contained a translocation between the long arms of chromosomes 15 and 17, but not at breakpoints typical for APL. Fluorescence in situ hybridization paints and RARα/PML cosmid probes verified that the breakpoints on chromosomes 15 and 17 were proximal to both the
PML and
RARα genes; t(15;17)(q13;12). Although the patient received induction chemotherapy and a several month trial of all-
trans retinoic acid (ATRA), there was no clinical improvement or hematological remission. We suspect that this patient developed postchemotherapy secondary APL with an atypical t(15;17), which rendered her leukemic cells unresponsive to ATRA therapy.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Chromosome Breakage - genetics</subject><subject>Chromosomes, Human, Pair 15 - genetics</subject><subject>Chromosomes, Human, Pair 17 - genetics</subject><subject>Drug Resistance, Neoplasm</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Leukemia, Promyelocytic, Acute - complications</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Retinoic Acid - genetics</subject><subject>Receptors, Retinoic Acid - metabolism</subject><subject>Retinoic Acid Receptor alpha</subject><subject>Toxicity: blood</subject><subject>Translocation, Genetic - genetics</subject><subject>Tretinoin - pharmacology</subject><subject>Tretinoin - therapeutic use</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAUhS0EokPhJ4C8oZpZBK5fSaZdoKqigFSJBbC2bpwb1ZDX2A7V_CD-J552Chs_pM_n-pzD2GsB7wSI8v23vJhCl1CvQW4AzFYU5glbibpShdamfMpW_5AT9iLGnwBQyW35nJ0IacDIElbsz2Xaz95hz9NamAtRbdY7oS52Qm64HznyGZOnMfE7n2459n3BU8Ax8kDJj5N3HJ1v860L6NIU9jySm8YW8wndkojPYRr21E9unzLd0_KLBo_n_DyLO4yU385TSBzHg8xvT3d86ni6Jd77RAHTEugle9ZhH-nVcT9lP64_fr_6XNx8_fTl6vKmILlVqdCdc9l_iU40tUCppelcXSrdNU50qtSa6gakrMV2q1VjoEMQrtKNaJWUYNQpO3vQzZ_eLRSTHXx01Pc40rREW8kapFFlBt8cwaUZqLVz8EO2bB-DzcDbI4Axp5vTGZ2P_zmtRQ3qMPHDA0fZVjYfbHQ5b0etD-SSbSdvBdhD5fa-cnvo04K095Vbo_4CGuecJw</recordid><startdate>20021015</startdate><enddate>20021015</enddate><creator>Kurian, Sobha</creator><creator>Hogan, Thomas F.</creator><creator>Bleigh, Ona C.</creator><creator>Dowdy, Yvonne G.</creator><creator>Merghoub, Taha</creator><creator>Pandolfi, Pier Paolo</creator><creator>Wenger, Sharon L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20021015</creationdate><title>Atypical t(15;17)(q13;q12) in a patient with all- trans retinoic acid refractory secondary acute promyelocytic leukemia: : a case report and review of the literature</title><author>Kurian, Sobha ; Hogan, Thomas F. ; Bleigh, Ona C. ; Dowdy, Yvonne G. ; Merghoub, Taha ; Pandolfi, Pier Paolo ; Wenger, Sharon L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e293t-4fcc1876ac1b81a2425fc8634fbc1f3644e8b022819943b50fa01c74b1d322053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Chromosome Breakage - genetics</topic><topic>Chromosomes, Human, Pair 15 - genetics</topic><topic>Chromosomes, Human, Pair 17 - genetics</topic><topic>Drug Resistance, Neoplasm</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Leukemia, Promyelocytic, Acute - complications</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Retinoic Acid - genetics</topic><topic>Receptors, Retinoic Acid - metabolism</topic><topic>Retinoic Acid Receptor alpha</topic><topic>Toxicity: blood</topic><topic>Translocation, Genetic - genetics</topic><topic>Tretinoin - pharmacology</topic><topic>Tretinoin - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>Kurian, Sobha</creatorcontrib><creatorcontrib>Hogan, Thomas F.</creatorcontrib><creatorcontrib>Bleigh, Ona C.</creatorcontrib><creatorcontrib>Dowdy, Yvonne G.</creatorcontrib><creatorcontrib>Merghoub, Taha</creatorcontrib><creatorcontrib>Pandolfi, Pier Paolo</creatorcontrib><creatorcontrib>Wenger, Sharon L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurian, Sobha</au><au>Hogan, Thomas F.</au><au>Bleigh, Ona C.</au><au>Dowdy, Yvonne G.</au><au>Merghoub, Taha</au><au>Pandolfi, Pier Paolo</au><au>Wenger, Sharon L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atypical t(15;17)(q13;q12) in a patient with all- trans retinoic acid refractory secondary acute promyelocytic leukemia: : a case report and review of the literature</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2002-10-15</date><risdate>2002</risdate><volume>138</volume><issue>2</issue><spage>143</spage><epage>148</epage><pages>143-148</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>A 69-year-old woman developed microgranular acute promyelocytic leukemia (APL-M3) 10 months after receiving adjuvant cyclophosphamide, doxorubicin, and paclitaxel for breast cancer. Replicate bone marrow aspirate karyotypes contained a translocation between the long arms of chromosomes 15 and 17, but not at breakpoints typical for APL. Fluorescence in situ hybridization paints and RARα/PML cosmid probes verified that the breakpoints on chromosomes 15 and 17 were proximal to both the
PML and
RARα genes; t(15;17)(q13;12). Although the patient received induction chemotherapy and a several month trial of all-
trans retinoic acid (ATRA), there was no clinical improvement or hematological remission. We suspect that this patient developed postchemotherapy secondary APL with an atypical t(15;17), which rendered her leukemic cells unresponsive to ATRA therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12505260</pmid><doi>10.1016/S0165-4608(02)00591-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 2002-10, Vol.138 (2), p.143-148 |
| issn | 0165-4608 1873-4456 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72802536 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Biological and medical sciences Bone Marrow - pathology Breast Neoplasms - complications Breast Neoplasms - drug therapy Breast Neoplasms - genetics Chromosome Breakage - genetics Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 17 - genetics Drug Resistance, Neoplasm Drug toxicity and drugs side effects treatment Female Humans In Situ Hybridization, Fluorescence Leukemia, Promyelocytic, Acute - complications Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Medical sciences Pharmacology. Drug treatments Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Retinoic Acid Receptor alpha Toxicity: blood Translocation, Genetic - genetics Tretinoin - pharmacology Tretinoin - therapeutic use |
| title | Atypical t(15;17)(q13;q12) in a patient with all- trans retinoic acid refractory secondary acute promyelocytic leukemia: : a case report and review of the literature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T17%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Atypical%20t(15;17)(q13;q12)%20in%20a%20patient%20with%20all-%20trans%20retinoic%20acid%20refractory%20secondary%20acute%20promyelocytic%20leukemia:%20:%20a%20case%20report%20and%20review%20of%20the%20literature&rft.jtitle=Cancer%20genetics%20and%20cytogenetics&rft.au=Kurian,%20Sobha&rft.date=2002-10-15&rft.volume=138&rft.issue=2&rft.spage=143&rft.epage=148&rft.pages=143-148&rft.issn=0165-4608&rft.eissn=1873-4456&rft.coden=CGCYDF&rft_id=info:doi/10.1016/S0165-4608(02)00591-5&rft_dat=%3Cproquest_pubme%3E72802536%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72802536&rft_id=info:pmid/12505260&rft_els_id=S0165460802005915&rfr_iscdi=true |