Sequence alignment of the G-protein coupled receptor superfamily
The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to i...
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| Veröffentlicht in: | DNA and cell biology 1992, Vol.11 (1), p.1-20 |
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| container_title | DNA and cell biology |
| container_volume | 11 |
| creator | PROBST, W. C SNYDER, L. A SCHUSTER, D. I BROSIUS, J SEALFON, S. C |
| description | The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for understanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling. |
| doi_str_mv | 10.1089/dna.1992.11.1 |
| format | Article |
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Genome</subject><subject>GTP-Binding Proteins</subject><subject>guanine nucleotide-binding protein</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>receptors</subject><subject>Receptors, Cell Surface</subject><subject>reviews</subject><subject>Sequence Alignment</subject><issn>1044-5498</issn><issn>1557-7430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EKqUwMiJlQGwpvtiO7Q1UQUGqxADMluNcIChf2MnQ_x5XrWBkON1J73dPT4-QS6BLoErflp1dgtbZEmAJR2QOQshUckaP4005TwXX6pSchfBFKRUZ0BmZAYu_Qs7J3St-T9g5TGxTf3QtdmPSV8n4ick6HXw_Yt0lrp-GBsvEo8Nh7H0SpgF9Zdu62Z6Tk8o2AS8Oe0HeHx_eVk_p5mX9vLrfpI5xNaY6gwLyQlUulyWjLpNaO1HEyV1RcMUViIoVPKNOAFeaOy4Z5kWJWtiS52xBbva-MVRMHEbT1sFh09gO-ykYmSmaUaX-BSFnUgGTEUz3oPN9CB4rM_i6tX5rgJpdtSZWa3bVGgADkb86GE9Fi-Ufve8y6tcH3QZnm8rbztXhFxMZ1ZwL9gMRTIBa</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>PROBST, W. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence alignment of the G-protein coupled receptor superfamily</atitle><jtitle>DNA and cell biology</jtitle><addtitle>DNA Cell Biol</addtitle><date>1992</date><risdate>1992</risdate><volume>11</volume><issue>1</issue><spage>1</spage><epage>20</epage><pages>1-20</pages><issn>1044-5498</issn><eissn>1557-7430</eissn><coden>DCEBE8</coden><abstract>The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for understanding the evolution of these genes. 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| fulltext | fulltext |
| identifier | ISSN: 1044-5498 |
| ispartof | DNA and cell biology, 1992, Vol.11 (1), p.1-20 |
| issn | 1044-5498 1557-7430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72802088 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Amino Acid Sequence Animals Biological and medical sciences comparison Fundamental and applied biological sciences. Psychology Genes. Genome GTP-Binding Proteins guanine nucleotide-binding protein Humans Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family receptors Receptors, Cell Surface reviews Sequence Alignment |
| title | Sequence alignment of the G-protein coupled receptor superfamily |
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