Steroidal Glycosides from the Leaves of Cestrum nocturnum
Further phytochemical analysis aimed at the steroidal glycoside constituents of the leaves of Cestrum nocturnum has resulted in the isolation of eight new steroidal glycosides (1-8), which were classified into a spirostanol saponin (1), a furostanol saponin (2), a pseudo-furostanol saponin (3), two...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2002-12, Vol.65 (12), p.1863-1868 |
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| container_end_page | 1868 |
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| container_issue | 12 |
| container_start_page | 1863 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 65 |
| creator | MIMAKI, Yoshihiro WATANABE, Kazuki SAKAGAMI, Hiroshi SASHIDA, Yutaka |
| description | Further phytochemical analysis aimed at the steroidal glycoside constituents of the leaves of Cestrum nocturnum has resulted in the isolation of eight new steroidal glycosides (1-8), which were classified into a spirostanol saponin (1), a furostanol saponin (2), a pseudo-furostanol saponin (3), two pregnane glycosides (4, 5), two cholestane glycosides (6, 7), and pregnane-carboxylic acid gamma-lactone glycoside (8), and of two known spirostanol glycosides (9, 10). The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence. |
| doi_str_mv | 10.1021/np020276f |
| format | Article |
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The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np020276f</identifier><identifier>PMID: 12502329</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acetylation ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Carcinoma, Squamous Cell ; Catalysis ; Cestrum - chemistry ; Doxorubicin - pharmacology ; Drug Screening Assays, Antitumor ; General pharmacology ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Humans ; Hydrolysis ; Japan ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. 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Drug treatments ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; Stereoisomerism ; Steroids - chemistry ; Steroids - isolation & purification ; Steroids - pharmacology ; Tumor Cells, Cultured - drug effects</subject><ispartof>Journal of natural products (Washington, D.C.), 2002-12, Vol.65 (12), p.1863-1868</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14464741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12502329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIMAKI, Yoshihiro</creatorcontrib><creatorcontrib>WATANABE, Kazuki</creatorcontrib><creatorcontrib>SAKAGAMI, Hiroshi</creatorcontrib><creatorcontrib>SASHIDA, Yutaka</creatorcontrib><title>Steroidal Glycosides from the Leaves of Cestrum nocturnum</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Further phytochemical analysis aimed at the steroidal glycoside constituents of the leaves of Cestrum nocturnum has resulted in the isolation of eight new steroidal glycosides (1-8), which were classified into a spirostanol saponin (1), a furostanol saponin (2), a pseudo-furostanol saponin (3), two pregnane glycosides (4, 5), two cholestane glycosides (6, 7), and pregnane-carboxylic acid gamma-lactone glycoside (8), and of two known spirostanol glycosides (9, 10). The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence.</description><subject>Acetylation</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell</subject><subject>Catalysis</subject><subject>Cestrum - chemistry</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Leaves - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Stereoisomerism</subject><subject>Steroids - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz8lOwzAQBmALgWhZDrwAygVugfGeHKGCFlGxtYijZdyxCGQpdoLo2xOpBU6_RvPp1wwhRxTOKDB6Xi-BAdPKb5EhlQxSBUxukyFQxVOeKTEgezG-AwCHXO6SAWUSGGf5kOSzFkNTLGyZjMuVa2KxwJj40FRJ-4bJFO1XPzc-GWFsQ1cldePaLtRddUB2vC0jHm5ynzxfX81Hk3R6P74ZXUzTgmnZphYs18pqLpRTznvMmM9RoJcqA8GUol7myuV99hQsIhcgJS6kQuqp5vvkdN27DM1n119hqiI6LEtbY9NFo1kGVGe8h8cb2L1WuDDLUFQ2rMzvsz042QAbnS19sLUr4r8TQgktaO_StStii99_exs-jNJcSzN_mJk7evsyeXyS5pL_AJ0zcLc</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>MIMAKI, Yoshihiro</creator><creator>WATANABE, Kazuki</creator><creator>SAKAGAMI, Hiroshi</creator><creator>SASHIDA, Yutaka</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Steroidal Glycosides from the Leaves of Cestrum nocturnum</title><author>MIMAKI, Yoshihiro ; WATANABE, Kazuki ; SAKAGAMI, Hiroshi ; SASHIDA, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i275t-a0a376a7346c6cffe82f9e4ef568042661f596c961fa0a0aee34055ed56e1f173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetylation</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell</topic><topic>Catalysis</topic><topic>Cestrum - chemistry</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General pharmacology</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Leaves - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Stereoisomerism</topic><topic>Steroids - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIMAKI, Yoshihiro</creatorcontrib><creatorcontrib>WATANABE, Kazuki</creatorcontrib><creatorcontrib>SAKAGAMI, Hiroshi</creatorcontrib><creatorcontrib>SASHIDA, Yutaka</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIMAKI, Yoshihiro</au><au>WATANABE, Kazuki</au><au>SAKAGAMI, Hiroshi</au><au>SASHIDA, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroidal Glycosides from the Leaves of Cestrum nocturnum</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>65</volume><issue>12</issue><spage>1863</spage><epage>1868</epage><pages>1863-1868</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Further phytochemical analysis aimed at the steroidal glycoside constituents of the leaves of Cestrum nocturnum has resulted in the isolation of eight new steroidal glycosides (1-8), which were classified into a spirostanol saponin (1), a furostanol saponin (2), a pseudo-furostanol saponin (3), two pregnane glycosides (4, 5), two cholestane glycosides (6, 7), and pregnane-carboxylic acid gamma-lactone glycoside (8), and of two known spirostanol glycosides (9, 10). The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>12502329</pmid><doi>10.1021/np020276f</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2002-12, Vol.65 (12), p.1863-1868 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Acetylation Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Carcinoma, Squamous Cell Catalysis Cestrum - chemistry Doxorubicin - pharmacology Drug Screening Assays, Antitumor General pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans Hydrolysis Japan Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry Stereoisomerism Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology Tumor Cells, Cultured - drug effects |
| title | Steroidal Glycosides from the Leaves of Cestrum nocturnum |
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