Growth‐inhibitory effect of quercetin and presence of type‐II estrogen‐binding sites in human colon‐cancer cell lines and primary colorectal tumors

We studied the effect of quercetin (Q) on the proliferation of HT‐29, WiDr, COLO 201, and LS‐174T human colon cancer cell lines. Q, between 10 nM and 10 μM, exerted a dose‐dependent, reversible inhibition of cell proliferation. Cell‐cycle analysis revealed that the growth‐inhibitory effect of Q was...

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Veröffentlicht in:	International journal of cancer 1992-02, Vol.50 (3), p.486-492
Hauptverfasser:	Ranelletti, Franco O., Ricci, Riccardo, Larocca, Luigi M., Maggiano, Nicola, Capelli, Arnaldo, Scambia, Giovanni, Benedetti‐Panici, Pierluigi, Mancuso, Salvatore, Rumi, Carlo, Piantelli, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Antineoplastic agents Biological and medical sciences Cell Cycle - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Estradiol - metabolism General aspects Growth Inhibitors - pharmacology Humans In Vitro Techniques Medical sciences Pharmacology. Drug treatments Quercetin - pharmacology Steroids - metabolism Tumor Cells, Cultured
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