The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer
Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99(m)Tc-HDP bone scans to gu...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2002-01, Vol.5 (2), p.144-151 |
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| creator | Brown, R S D Dogan, A Ell, P J Payne, H A Masters, J R W Harland, S J |
| description | Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99(m)Tc-HDP bone scans to guide the procedure. All samples taken were for the purposes of research and molecular studies on HRPC. Twenty patients with HRPC had bone marrow aspirate and trephines taken from lesions in the posterior superior iliac spine or sacro-iliac region when shown on diagnostic 99(m)Tc-HDP bone scans. Three patients also underwent plain X-ray, 18F-positron emission tomography bone scan, pelvic MRI scan and 99(m)Tc nanocolloid bone marrow scans. These images were used to assess if the extra imaging information provided, such as three-dimensional localisation of the bone metastases, was of value for target bone metastases. Cancer cells were obtained in 15/20 (75%) cases in which a trephine biopsy was attempted and 0/20 of cases in which a bone marrow aspiration was attempted. The additional information provided by the range of other imaging investigations was of little benefit in obtaining tumour samples, but did suggest why negative biopsies were obtained in some cases after targeting with planar bone scans. We recommend the use of bone marrow trephine biopsy alone, guided by previous diagnostic 99(m)Tc planar bone scan as a practical method to obtain prostate cancer cells from bone metastases. |
| doi_str_mv | 10.1038/sj.pcan.4500581 |
| format | Article |
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The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99(m)Tc-HDP bone scans to guide the procedure. All samples taken were for the purposes of research and molecular studies on HRPC. Twenty patients with HRPC had bone marrow aspirate and trephines taken from lesions in the posterior superior iliac spine or sacro-iliac region when shown on diagnostic 99(m)Tc-HDP bone scans. Three patients also underwent plain X-ray, 18F-positron emission tomography bone scan, pelvic MRI scan and 99(m)Tc nanocolloid bone marrow scans. These images were used to assess if the extra imaging information provided, such as three-dimensional localisation of the bone metastases, was of value for target bone metastases. Cancer cells were obtained in 15/20 (75%) cases in which a trephine biopsy was attempted and 0/20 of cases in which a bone marrow aspiration was attempted. The additional information provided by the range of other imaging investigations was of little benefit in obtaining tumour samples, but did suggest why negative biopsies were obtained in some cases after targeting with planar bone scans. We recommend the use of bone marrow trephine biopsy alone, guided by previous diagnostic 99(m)Tc planar bone scan as a practical method to obtain prostate cancer cells from bone metastases.</description><identifier>ISSN: 1365-7852</identifier><identifier>EISSN: 1476-5608</identifier><identifier>DOI: 10.1038/sj.pcan.4500581</identifier><identifier>PMID: 12497005</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal - pharmacology ; Biopsy ; Biopsy, Needle - methods ; Bone cancer ; Bone imaging ; Bone marrow ; Bone marrow examination ; Bone Marrow Examination - methods ; Bone Marrow Neoplasms - diagnostic imaging ; Bone Marrow Neoplasms - pathology ; Bone Marrow Neoplasms - secondary ; Care and treatment ; Comparative analysis ; Diagnosis ; Diagnostic systems ; Drug Resistance, Neoplasm ; Health aspects ; Humans ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Metastases ; Metastasis ; Middle Aged ; Pelvis ; Positron emission ; Positron emission tomography ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - pathology ; Radiopharmaceuticals ; Risk factors ; Scintigraphy ; Spine ; Technetium Tc 99m Medronate - analogs & derivatives ; Tomography, Emission-Computed ; Tumors</subject><ispartof>Prostate cancer and prostatic diseases, 2002-01, Vol.5 (2), p.144-151</ispartof><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group 2002</rights><rights>Macmillan Publishers Limited 2002.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-5c3baba1ba32338977a75615d09defdf59de4d2d59e902622e928e7edd37d9303</citedby><cites>FETCH-LOGICAL-c487t-5c3baba1ba32338977a75615d09defdf59de4d2d59e902622e928e7edd37d9303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12497005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, R S D</creatorcontrib><creatorcontrib>Dogan, A</creatorcontrib><creatorcontrib>Ell, P J</creatorcontrib><creatorcontrib>Payne, H A</creatorcontrib><creatorcontrib>Masters, J R W</creatorcontrib><creatorcontrib>Harland, S J</creatorcontrib><title>The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer</title><title>Prostate cancer and prostatic diseases</title><addtitle>Prostate Cancer Prostatic Dis</addtitle><description>Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99(m)Tc-HDP bone scans to guide the procedure. All samples taken were for the purposes of research and molecular studies on HRPC. Twenty patients with HRPC had bone marrow aspirate and trephines taken from lesions in the posterior superior iliac spine or sacro-iliac region when shown on diagnostic 99(m)Tc-HDP bone scans. Three patients also underwent plain X-ray, 18F-positron emission tomography bone scan, pelvic MRI scan and 99(m)Tc nanocolloid bone marrow scans. These images were used to assess if the extra imaging information provided, such as three-dimensional localisation of the bone metastases, was of value for target bone metastases. Cancer cells were obtained in 15/20 (75%) cases in which a trephine biopsy was attempted and 0/20 of cases in which a bone marrow aspiration was attempted. The additional information provided by the range of other imaging investigations was of little benefit in obtaining tumour samples, but did suggest why negative biopsies were obtained in some cases after targeting with planar bone scans. We recommend the use of bone marrow trephine biopsy alone, guided by previous diagnostic 99(m)Tc planar bone scan as a practical method to obtain prostate cancer cells from bone metastases.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents, Hormonal - pharmacology</subject><subject>Biopsy</subject><subject>Biopsy, Needle - methods</subject><subject>Bone cancer</subject><subject>Bone imaging</subject><subject>Bone marrow</subject><subject>Bone marrow examination</subject><subject>Bone Marrow Examination - methods</subject><subject>Bone Marrow Neoplasms - diagnostic imaging</subject><subject>Bone Marrow Neoplasms - pathology</subject><subject>Bone Marrow Neoplasms - secondary</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Drug Resistance, Neoplasm</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Pelvis</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Radiopharmaceuticals</subject><subject>Risk factors</subject><subject>Scintigraphy</subject><subject>Spine</subject><subject>Technetium Tc 99m Medronate - analogs & derivatives</subject><subject>Tomography, Emission-Computed</subject><subject>Tumors</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kktr3DAQx01padK0596KaCE3b_SwLOkYQl8Q6CU9C9kar7XYlitpU_Ip-pU7yy6kKS0SjJB-_3lpquotoxtGhb7Ku83au2XTSEqlZs-qc9aotpYt1c_xLFpZKy35WfUq5x2l1DBDX1ZnjDdGoeK8-nU3AunjvLrkSrgHcu-mPWQSB9LFBcjsUoo_ictrQACIWzwpCdYx4OMQE4ldcWEJy_bIZ8ymLi5toYAnMxSXcaPDIcWZjDHNSNUJhuT6EtMDWVNEAj2jsIf0unoxuCnDm5O9qL5_-nh386W-_fb56831bd03WpVa9qJznWOdE1wIbZRySrZMemo8DH6QaBrPvTRgKG85B8M1KPBeKG8EFRfV5dEvxv-BBRc7h9zDNLkF4j5bxZVpjRYIfvgL3MV9WjA3y9tGYnhNW6Te_5filLVSK_7oausmsGEZYsEuHOLaa06p0prpBqnNPyhcHubQY_eGgPdPBJd_CEZwUxlznPYlxCU_Ba-OYI89z_gHdk0BP_jBMmoP42Tzzh7GyZ7GCRXvTmXtuxn8I3-aH_EbFKjHGw</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Brown, R S D</creator><creator>Dogan, A</creator><creator>Ell, P J</creator><creator>Payne, H A</creator><creator>Masters, J R W</creator><creator>Harland, S J</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer</title><author>Brown, R S D ; Dogan, A ; Ell, P J ; Payne, H A ; Masters, J R W ; Harland, S J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-5c3baba1ba32338977a75615d09defdf59de4d2d59e902622e928e7edd37d9303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents, Hormonal - pharmacology</topic><topic>Biopsy</topic><topic>Biopsy, Needle - methods</topic><topic>Bone cancer</topic><topic>Bone imaging</topic><topic>Bone marrow</topic><topic>Bone marrow examination</topic><topic>Bone Marrow Examination - methods</topic><topic>Bone Marrow Neoplasms - diagnostic imaging</topic><topic>Bone Marrow Neoplasms - pathology</topic><topic>Bone Marrow Neoplasms - secondary</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Drug Resistance, Neoplasm</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Pelvis</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Radiopharmaceuticals</topic><topic>Risk factors</topic><topic>Scintigraphy</topic><topic>Spine</topic><topic>Technetium Tc 99m Medronate - analogs & derivatives</topic><topic>Tomography, Emission-Computed</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, R S D</creatorcontrib><creatorcontrib>Dogan, A</creatorcontrib><creatorcontrib>Ell, P J</creatorcontrib><creatorcontrib>Payne, H A</creatorcontrib><creatorcontrib>Masters, J R W</creatorcontrib><creatorcontrib>Harland, S J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, R S D</au><au>Dogan, A</au><au>Ell, P J</au><au>Payne, H A</au><au>Masters, J R W</au><au>Harland, S J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>5</volume><issue>2</issue><spage>144</spage><epage>151</epage><pages>144-151</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract>Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99(m)Tc-HDP bone scans to guide the procedure. All samples taken were for the purposes of research and molecular studies on HRPC. Twenty patients with HRPC had bone marrow aspirate and trephines taken from lesions in the posterior superior iliac spine or sacro-iliac region when shown on diagnostic 99(m)Tc-HDP bone scans. Three patients also underwent plain X-ray, 18F-positron emission tomography bone scan, pelvic MRI scan and 99(m)Tc nanocolloid bone marrow scans. These images were used to assess if the extra imaging information provided, such as three-dimensional localisation of the bone metastases, was of value for target bone metastases. Cancer cells were obtained in 15/20 (75%) cases in which a trephine biopsy was attempted and 0/20 of cases in which a bone marrow aspiration was attempted. The additional information provided by the range of other imaging investigations was of little benefit in obtaining tumour samples, but did suggest why negative biopsies were obtained in some cases after targeting with planar bone scans. We recommend the use of bone marrow trephine biopsy alone, guided by previous diagnostic 99(m)Tc planar bone scan as a practical method to obtain prostate cancer cells from bone metastases.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>12497005</pmid><doi>10.1038/sj.pcan.4500581</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Antineoplastic Agents, Hormonal - pharmacology Biopsy Biopsy, Needle - methods Bone cancer Bone imaging Bone marrow Bone marrow examination Bone Marrow Examination - methods Bone Marrow Neoplasms - diagnostic imaging Bone Marrow Neoplasms - pathology Bone Marrow Neoplasms - secondary Care and treatment Comparative analysis Diagnosis Diagnostic systems Drug Resistance, Neoplasm Health aspects Humans Magnetic Resonance Imaging Male Medical imaging Metastases Metastasis Middle Aged Pelvis Positron emission Positron emission tomography Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Radiopharmaceuticals Risk factors Scintigraphy Spine Technetium Tc 99m Medronate - analogs & derivatives Tomography, Emission-Computed Tumors |
| title | The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer |
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