Tissue localization of 11β-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor

11β-Hydroxysteroid dehydrogenase (11β-HSD) dictates specificity for the mineralocorticoid receptor (MR) by converting the active steroid cortisol to cortisone in man (corticosterone to 11-dehydrocorticosterone in rodents), leaving aldosterone to occupy the MR. However cortisol is the principal circu...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1992, Vol.41 (1), p.21-28
Hauptverfasser:	Whorwood, C.B., Franklyn, J.A., Sheppard, M.C., Stewart, P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenases Analytical, structural and metabolic biochemistry Animals Autoradiography Biological and medical sciences Blotting, Northern DNA Probes Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Hydroxysteroid Dehydrogenases - analysis Hydroxysteroid Dehydrogenases - genetics Hydroxysteroid Dehydrogenases - metabolism Kidney - enzymology Liver - enzymology Male Organ Specificity Oxidoreductases Phosphorus Radioisotopes Rats Rats, Inbred Strains Receptors, Glucocorticoid - metabolism RNA, Messenger - analysis RNA, Messenger - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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