Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex
GABA is the main inhibitory neurotransmitter in the adult brain. However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression of cation–Cl co-transporters regulating neuronal Cl homeostasis underlie the ontogeny of GABAergic functions....
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| Veröffentlicht in: | Neuroreport 2002-12, Vol.13 (18), p.2433-2437 |
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| container_title | Neuroreport |
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| creator | Shimizu-Okabe, Chigusa Yokokura, Masamichi Okabe, Akihito Ikeda, Masahiko Sato, Kohji Kilb, Werner Luhmann, Heiko J Fukuda, Atsuo |
| description | GABA is the main inhibitory neurotransmitter in the adult brain. However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression of cation–Cl co-transporters regulating neuronal Cl homeostasis underlie the ontogeny of GABAergic functions. The developmental changes in the expressions of Cl co-transporter mRNAs in the neocortex were in opposite directions for NKCC1 (Cl uptake) and KCC2 (Cl extrusion). In the newborn, NKCC1 mRNA expression was highest in ventricular zone followed by cortical plate, and then by Layer V/VI, while the reverse was true for KCC2 mRNA. The [Cl]i levels were in the same rank order as for NKCC1 mRNA. Thus, the ontogeny of Cl homeostasis in neocortical neurons could be regulated via the differential expression of NKCC1 and KCC2. |
| doi_str_mv | 10.1097/00001756-200212200-00012 |
| format | Article |
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However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression of cation–Cl co-transporters regulating neuronal Cl homeostasis underlie the ontogeny of GABAergic functions. The developmental changes in the expressions of Cl co-transporter mRNAs in the neocortex were in opposite directions for NKCC1 (Cl uptake) and KCC2 (Cl extrusion). In the newborn, NKCC1 mRNA expression was highest in ventricular zone followed by cortical plate, and then by Layer V/VI, while the reverse was true for KCC2 mRNA. The [Cl]i levels were in the same rank order as for NKCC1 mRNA. Thus, the ontogeny of Cl homeostasis in neocortical neurons could be regulated via the differential expression of NKCC1 and KCC2.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200212200-00012</identifier><identifier>PMID: 12499844</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Animals, Newborn ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Cerebral Cortex - metabolism ; Chlorides - metabolism ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - physiology ; Gene Expression Regulation, Developmental ; K Cl- Cotransporters ; Male ; Rats ; Rats, Wistar ; RNA, Messenger - analysis ; Sodium-Potassium-Chloride Symporters - genetics ; Sodium-Potassium-Chloride Symporters - metabolism ; Solute Carrier Family 12, Member 2 ; Symporters - genetics ; Symporters - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2002-12, Vol.13 (18), p.2433-2437</ispartof><rights>2002 Lippincott Williams & Wilkins, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3672-5e86b25ed318b3c0f6e75709655c006d4743ef0e7bf4b5311e9c94fcdf8567bc3</citedby><cites>FETCH-LOGICAL-c3672-5e86b25ed318b3c0f6e75709655c006d4743ef0e7bf4b5311e9c94fcdf8567bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14533684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12499844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu-Okabe, Chigusa</creatorcontrib><creatorcontrib>Yokokura, Masamichi</creatorcontrib><creatorcontrib>Okabe, Akihito</creatorcontrib><creatorcontrib>Ikeda, Masahiko</creatorcontrib><creatorcontrib>Sato, Kohji</creatorcontrib><creatorcontrib>Kilb, Werner</creatorcontrib><creatorcontrib>Luhmann, Heiko J</creatorcontrib><creatorcontrib>Fukuda, Atsuo</creatorcontrib><title>Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>GABA is the main inhibitory neurotransmitter in the adult brain. However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression of cation–Cl co-transporters regulating neuronal Cl homeostasis underlie the ontogeny of GABAergic functions. The developmental changes in the expressions of Cl co-transporter mRNAs in the neocortex were in opposite directions for NKCC1 (Cl uptake) and KCC2 (Cl extrusion). In the newborn, NKCC1 mRNA expression was highest in ventricular zone followed by cortical plate, and then by Layer V/VI, while the reverse was true for KCC2 mRNA. The [Cl]i levels were in the same rank order as for NKCC1 mRNA. Thus, the ontogeny of Cl homeostasis in neocortical neurons could be regulated via the differential expression of NKCC1 and KCC2.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - metabolism</subject><subject>Chlorides - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>K Cl- Cotransporters</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - analysis</subject><subject>Sodium-Potassium-Chloride Symporters - genetics</subject><subject>Sodium-Potassium-Chloride Symporters - metabolism</subject><subject>Solute Carrier Family 12, Member 2</subject><subject>Symporters - genetics</subject><subject>Symporters - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9q3DAQh0VpaLZpX6Ho0t7cSNb_Y1iapLDQSwKFUoQsj4gSre1KXnbzBjn3EfMksbPb5NQ5aEB8P83wCSFMyVdKjDolU1ElZFUTUtN6Oqv5pn6DFpQrVgmhf75FC2KEqbiR4hi9L-V2Qgyh-h06pjU3RnO-QHbl7iFXZQAfQ_QYdkOGUmLf4T7gZXp8-IvH7Loy9HmEXLDrWtzGECBDN0aX8K9n6HfEscMdbJs-dzi7Efs5sPuAjoJLBT4e-gm6Pv92tbysVj8uvi_PVpVnUtWVAC2bWkDLqG6YJ0GCEopMqwtPiGy54gwCAdUE3ghGKRhvePBt0EKqxrMT9GX_7pD7Pxsoo13H4iEl10G_KVbVykhNzQTqPehzX0qGYIcc1y7fW0rsLNf-k2tf5NpnuVP002HGpllD-xo82JyAzwfAFe9SmLz5WF45LhiTeub4ntv2aZZ6lzZbyPYGXBpv7P8-lz0BKkKTpQ</recordid><startdate>20021220</startdate><enddate>20021220</enddate><creator>Shimizu-Okabe, Chigusa</creator><creator>Yokokura, Masamichi</creator><creator>Okabe, Akihito</creator><creator>Ikeda, Masahiko</creator><creator>Sato, Kohji</creator><creator>Kilb, Werner</creator><creator>Luhmann, Heiko J</creator><creator>Fukuda, Atsuo</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021220</creationdate><title>Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex</title><author>Shimizu-Okabe, Chigusa ; Yokokura, Masamichi ; Okabe, Akihito ; Ikeda, Masahiko ; Sato, Kohji ; Kilb, Werner ; Luhmann, Heiko J ; Fukuda, Atsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3672-5e86b25ed318b3c0f6e75709655c006d4743ef0e7bf4b5311e9c94fcdf8567bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - metabolism</topic><topic>Chlorides - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>K Cl- Cotransporters</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - analysis</topic><topic>Sodium-Potassium-Chloride Symporters - genetics</topic><topic>Sodium-Potassium-Chloride Symporters - metabolism</topic><topic>Solute Carrier Family 12, Member 2</topic><topic>Symporters - genetics</topic><topic>Symporters - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu-Okabe, Chigusa</creatorcontrib><creatorcontrib>Yokokura, Masamichi</creatorcontrib><creatorcontrib>Okabe, Akihito</creatorcontrib><creatorcontrib>Ikeda, Masahiko</creatorcontrib><creatorcontrib>Sato, Kohji</creatorcontrib><creatorcontrib>Kilb, Werner</creatorcontrib><creatorcontrib>Luhmann, Heiko J</creatorcontrib><creatorcontrib>Fukuda, Atsuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu-Okabe, Chigusa</au><au>Yokokura, Masamichi</au><au>Okabe, Akihito</au><au>Ikeda, Masahiko</au><au>Sato, Kohji</au><au>Kilb, Werner</au><au>Luhmann, Heiko J</au><au>Fukuda, Atsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2002-12-20</date><risdate>2002</risdate><volume>13</volume><issue>18</issue><spage>2433</spage><epage>2437</epage><pages>2433-2437</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>GABA is the main inhibitory neurotransmitter in the adult brain. However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression of cation–Cl co-transporters regulating neuronal Cl homeostasis underlie the ontogeny of GABAergic functions. The developmental changes in the expressions of Cl co-transporter mRNAs in the neocortex were in opposite directions for NKCC1 (Cl uptake) and KCC2 (Cl extrusion). In the newborn, NKCC1 mRNA expression was highest in ventricular zone followed by cortical plate, and then by Layer V/VI, while the reverse was true for KCC2 mRNA. The [Cl]i levels were in the same rank order as for NKCC1 mRNA. Thus, the ontogeny of Cl homeostasis in neocortical neurons could be regulated via the differential expression of NKCC1 and KCC2.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>12499844</pmid><doi>10.1097/00001756-200212200-00012</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Animals, Newborn Biochemistry and metabolism Biological and medical sciences Central nervous system Cerebral Cortex - metabolism Chlorides - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - physiology Gene Expression Regulation, Developmental K Cl- Cotransporters Male Rats Rats, Wistar RNA, Messenger - analysis Sodium-Potassium-Chloride Symporters - genetics Sodium-Potassium-Chloride Symporters - metabolism Solute Carrier Family 12, Member 2 Symporters - genetics Symporters - metabolism Vertebrates: nervous system and sense organs |
| title | Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex |
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