Mechanisms of corticosteroid action in immune thrombocytopenic purpura (ITP) : experimental studies using ITP-prone mice, (NZW × BXSB) F1

To determine the mechanism by which platelet counts increase after corticosteroid therapy for human immune thrombocytopenic purpura (ITP), we studied the platelet kinetics using prednisolone (PDN)-treated ITP-prone mice, (NZW x BXSB) F1 (W/B F1). An increase in platelet counts was observed in W/B F1...

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Veröffentlicht in:	Blood 1992-02, Vol.79 (4), p.942-947
Hauptverfasser:	MIZUTANI, H, FURUBAYASHI, T, IMAI, Y, KASHIWAGI, H, HONDA, S, TAKE, H, KURATA, Y, YONEZAWA, T, TARUI, S, IKEHARA, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - blood Biological and medical sciences Blood Platelets - drug effects Blood Platelets - immunology Blood Platelets - physiology Cell Survival - drug effects Erythrocytes - immunology Female Flow Cytometry Hematologic and hematopoietic diseases Immunoglobulin G Liver - physiopathology Macrophages - drug effects Macrophages - physiology Male Medical sciences Mice Mice, Inbred BALB C Phagocytosis - drug effects Platelet Count Platelet diseases and coagulopathies Prednisolone - pharmacology Prednisolone - therapeutic use Purpura, Thrombocytopenic, Idiopathic - blood Purpura, Thrombocytopenic, Idiopathic - drug therapy Purpura, Thrombocytopenic, Idiopathic - physiopathology Receptors, Fc - metabolism
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