DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group
The mutant allele pso3-1 of Saccharomyces cerevisiae confers sensitivity to treatment with UV365nm (UVA) light-activated mono- and bi-functional psoralens. When pso3-1 is combined in double mutants with selected rad and pso mutant alleles and subjected to 8-MOP + UVA treatment, epistatic interaction...
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| Veröffentlicht in: | Current genetics 1992, Vol.21 (1), p.85-90 |
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| container_title | Current genetics |
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| creator | Benfato, M.S Brendel, M Henriques, J.A.P |
| description | The mutant allele pso3-1 of Saccharomyces cerevisiae confers sensitivity to treatment with UV365nm (UVA) light-activated mono- and bi-functional psoralens. When pso3-1 is combined in double mutants with selected rad and pso mutant alleles and subjected to 8-MOP + UVA treatment, epistatic interaction with regard to survival is observed with pso1, pso2, and rad3. With the same treatment the combination of pso3-1 with rad6 and rad52 leads to synergistic interaction. For the monofunctional agent 3-carbethoxypsoralen (3-CPs) the analysis of double mutants yields the same results as with the bifunctional 8-methoxypsoralen (8-MOP) with the exception of the pso1-1pso3-1 double mutant. Here we find an additive interaction, i.e., the sensitivities of both parental strains are summed in the double mutant, which indicates a different substrate specificity of the repair activity encoded by the PSO1 and PSO3 genes. |
| doi_str_mv | 10.1007/BF00318660 |
| format | Article |
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When pso3-1 is combined in double mutants with selected rad and pso mutant alleles and subjected to 8-MOP + UVA treatment, epistatic interaction with regard to survival is observed with pso1, pso2, and rad3. With the same treatment the combination of pso3-1 with rad6 and rad52 leads to synergistic interaction. For the monofunctional agent 3-carbethoxypsoralen (3-CPs) the analysis of double mutants yields the same results as with the bifunctional 8-methoxypsoralen (8-MOP) with the exception of the pso1-1pso3-1 double mutant. Here we find an additive interaction, i.e., the sensitivities of both parental strains are summed in the double mutant, which indicates a different substrate specificity of the repair activity encoded by the PSO1 and PSO3 genes.</description><identifier>ISSN: 0172-8083</identifier><identifier>EISSN: 1432-0983</identifier><identifier>DOI: 10.1007/BF00318660</identifier><identifier>PMID: 1735129</identifier><identifier>CODEN: CUGED5</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>3-carboxypsoralen ; Alleles ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; DNA Damage ; DNA Repair ; DNA, Fungal - genetics ; DNA, Fungal - metabolism ; epistasis ; Epistasis, Genetic ; Fundamental and applied biological sciences. Psychology ; Furocoumarins - pharmacology ; genes ; Genes, Fungal ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; methoxsalen ; Methoxsalen - pharmacology ; mutagenicity ; mutants ; Mutation ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae - radiation effects ; ultraviolet radiation ; Ultraviolet Rays</subject><ispartof>Current genetics, 1992, Vol.21 (1), p.85-90</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-3d7c7ec4d4f593e501f272b6a4fcda02469f745003cf09ab279ba48e02dd00903</citedby><cites>FETCH-LOGICAL-c335t-3d7c7ec4d4f593e501f272b6a4fcda02469f745003cf09ab279ba48e02dd00903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5162205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1735129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benfato, M.S</creatorcontrib><creatorcontrib>Brendel, M</creatorcontrib><creatorcontrib>Henriques, J.A.P</creatorcontrib><title>DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group</title><title>Current genetics</title><addtitle>Curr Genet</addtitle><description>The mutant allele pso3-1 of Saccharomyces cerevisiae confers sensitivity to treatment with UV365nm (UVA) light-activated mono- and bi-functional psoralens. When pso3-1 is combined in double mutants with selected rad and pso mutant alleles and subjected to 8-MOP + UVA treatment, epistatic interaction with regard to survival is observed with pso1, pso2, and rad3. With the same treatment the combination of pso3-1 with rad6 and rad52 leads to synergistic interaction. For the monofunctional agent 3-carbethoxypsoralen (3-CPs) the analysis of double mutants yields the same results as with the bifunctional 8-methoxypsoralen (8-MOP) with the exception of the pso1-1pso3-1 double mutant. Here we find an additive interaction, i.e., the sensitivities of both parental strains are summed in the double mutant, which indicates a different substrate specificity of the repair activity encoded by the PSO1 and PSO3 genes.</description><subject>3-carboxypsoralen</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA Damage</subject><subject>DNA Repair</subject><subject>DNA, Fungal - genetics</subject><subject>DNA, Fungal - metabolism</subject><subject>epistasis</subject><subject>Epistasis, Genetic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Furocoumarins - pharmacology</subject><subject>genes</subject><subject>Genes, Fungal</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>methoxsalen</subject><subject>Methoxsalen - pharmacology</subject><subject>mutagenicity</subject><subject>mutants</subject><subject>Mutation</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae - radiation effects</subject><subject>ultraviolet radiation</subject><subject>Ultraviolet Rays</subject><issn>0172-8083</issn><issn>1432-0983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0ctP5DAMB-AILYLhceGONge0h5UKzqNNexzeSAgQA-fKTZ2hqDMpSWcl_nuymhGcfPBnS_6ZsSMBpwLAnJ1fAyhRFgVssYnQSmZQleoXm4AwMiuhVLtsL8Z3ACHLyuywHWFULmQ1YS-XD1MeaMAu8DktiT_NHhX3js_Q2jcMfvFpKXJLgf51sUPiDfV-OY989Hx8I_48vVSchi6OGLvI58GvhgO27bCPdLip--z1-url4ja7f7y5u5jeZ1apfMxUa6whq1vt8kpRDsJJI5sCtbMtgtRF5YzO023WQYWNNFWDuiSQbQtQgdpnf9Z7h-A_VhTHetFFS32PS_KrWJs0kctCJvh3DW3wMQZy9RC6BYbPWkD9P8L6J8KEjzdbV82C2h-6ziz1TzZ9jBZ7F3Bpu_jNclFICXliv9fMoa9xHhJ5nUkQKj1Fa53EFzHdfzs</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Benfato, M.S</creator><creator>Brendel, M</creator><creator>Henriques, J.A.P</creator><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group</title><author>Benfato, M.S ; Brendel, M ; Henriques, J.A.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-3d7c7ec4d4f593e501f272b6a4fcda02469f745003cf09ab279ba48e02dd00903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>3-carboxypsoralen</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA Damage</topic><topic>DNA Repair</topic><topic>DNA, Fungal - genetics</topic><topic>DNA, Fungal - metabolism</topic><topic>epistasis</topic><topic>Epistasis, Genetic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Furocoumarins - pharmacology</topic><topic>genes</topic><topic>Genes, Fungal</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human</topic><topic>methoxsalen</topic><topic>Methoxsalen - pharmacology</topic><topic>mutagenicity</topic><topic>mutants</topic><topic>Mutation</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae - radiation effects</topic><topic>ultraviolet radiation</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benfato, M.S</creatorcontrib><creatorcontrib>Brendel, M</creatorcontrib><creatorcontrib>Henriques, J.A.P</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benfato, M.S</au><au>Brendel, M</au><au>Henriques, J.A.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group</atitle><jtitle>Current genetics</jtitle><addtitle>Curr Genet</addtitle><date>1992</date><risdate>1992</risdate><volume>21</volume><issue>1</issue><spage>85</spage><epage>90</epage><pages>85-90</pages><issn>0172-8083</issn><eissn>1432-0983</eissn><coden>CUGED5</coden><abstract>The mutant allele pso3-1 of Saccharomyces cerevisiae confers sensitivity to treatment with UV365nm (UVA) light-activated mono- and bi-functional psoralens. When pso3-1 is combined in double mutants with selected rad and pso mutant alleles and subjected to 8-MOP + UVA treatment, epistatic interaction with regard to survival is observed with pso1, pso2, and rad3. With the same treatment the combination of pso3-1 with rad6 and rad52 leads to synergistic interaction. For the monofunctional agent 3-carbethoxypsoralen (3-CPs) the analysis of double mutants yields the same results as with the bifunctional 8-methoxypsoralen (8-MOP) with the exception of the pso1-1pso3-1 double mutant. Here we find an additive interaction, i.e., the sensitivities of both parental strains are summed in the double mutant, which indicates a different substrate specificity of the repair activity encoded by the PSO1 and PSO3 genes.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>1735129</pmid><doi>10.1007/BF00318660</doi><tpages>6</tpages></addata></record> |
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| ispartof | Current genetics, 1992, Vol.21 (1), p.85-90 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | 3-carboxypsoralen Alleles Biological and medical sciences Classical genetics, quantitative genetics, hybrids DNA Damage DNA Repair DNA, Fungal - genetics DNA, Fungal - metabolism epistasis Epistasis, Genetic Fundamental and applied biological sciences. Psychology Furocoumarins - pharmacology genes Genes, Fungal Genetics of eukaryotes. Biological and molecular evolution Human methoxsalen Methoxsalen - pharmacology mutagenicity mutants Mutation Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - radiation effects ultraviolet radiation Ultraviolet Rays |
| title | DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group |
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