Use of cauda epididymis extract as immunocontraceptive
The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of C...
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| Veröffentlicht in: | Contraception (Stoneham) 2002-12, Vol.66 (6), p.459-462 |
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| container_title | Contraception (Stoneham) |
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| creator | Risvanli, Ali Aydin, Muhterem Kaygusuzoglu, Erdal Bulut, Hakan Apaydin, A.Mukremin Timurkan, Huseyin |
| description | The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 × 10
9 sperm/mL, while primipara rats received injections of CEE containing 3 × 10
6 sperm/mL up to three times. Animals were tested for the presence and concentration of anti-CEE antibody by enzyme-linked immunosorbent assay (ELISA) and monitored for pregnancy following natural insemination. Results revealed that 38 (92.6%) of the 41 rats were positive for anti-CEE antibodies, regardless of animal type or immunization procedure. However, there was no relation between pregnancy rates and concentration of anti-CEE antibody in rats immunized with CEE. These results indicate that immune response against CEE may not play a major role in contraception in rats. |
| doi_str_mv | 10.1016/S0010-7824(02)00406-7 |
| format | Article |
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9 sperm/mL, while primipara rats received injections of CEE containing 3 × 10
6 sperm/mL up to three times. Animals were tested for the presence and concentration of anti-CEE antibody by enzyme-linked immunosorbent assay (ELISA) and monitored for pregnancy following natural insemination. Results revealed that 38 (92.6%) of the 41 rats were positive for anti-CEE antibodies, regardless of animal type or immunization procedure. However, there was no relation between pregnancy rates and concentration of anti-CEE antibody in rats immunized with CEE. These results indicate that immune response against CEE may not play a major role in contraception in rats.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/S0010-7824(02)00406-7</identifier><identifier>PMID: 12499040</identifier><identifier>CODEN: CCPTAY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antibodies - blood ; Antigens - immunology ; Biological and medical sciences ; Birth control ; Cauda epididymis extract ; Contraception, Immunologic ; Enzyme-Linked Immunosorbent Assay ; Epididymis - immunology ; Female ; Gynecology. Andrology. Obstetrics ; Immunization ; Immunocontraception ; Male ; Medical sciences ; Other methods of contraception. Sterilization ; Parturition ; Pregnancy ; Rat ; Rats ; Sexual Maturation ; Tissue Extracts - immunology</subject><ispartof>Contraception (Stoneham), 2002-12, Vol.66 (6), p.459-462</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-bf9db0fb641617f933816135c7f0347827b00020f5836a0a53579af320875c433</citedby><cites>FETCH-LOGICAL-c391t-bf9db0fb641617f933816135c7f0347827b00020f5836a0a53579af320875c433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0010-7824(02)00406-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14442701$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12499040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Risvanli, Ali</creatorcontrib><creatorcontrib>Aydin, Muhterem</creatorcontrib><creatorcontrib>Kaygusuzoglu, Erdal</creatorcontrib><creatorcontrib>Bulut, Hakan</creatorcontrib><creatorcontrib>Apaydin, A.Mukremin</creatorcontrib><creatorcontrib>Timurkan, Huseyin</creatorcontrib><title>Use of cauda epididymis extract as immunocontraceptive</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 × 10
9 sperm/mL, while primipara rats received injections of CEE containing 3 × 10
6 sperm/mL up to three times. Animals were tested for the presence and concentration of anti-CEE antibody by enzyme-linked immunosorbent assay (ELISA) and monitored for pregnancy following natural insemination. Results revealed that 38 (92.6%) of the 41 rats were positive for anti-CEE antibodies, regardless of animal type or immunization procedure. However, there was no relation between pregnancy rates and concentration of anti-CEE antibody in rats immunized with CEE. These results indicate that immune response against CEE may not play a major role in contraception in rats.</description><subject>Animals</subject><subject>Antibodies - blood</subject><subject>Antigens - immunology</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Cauda epididymis extract</subject><subject>Contraception, Immunologic</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epididymis - immunology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Immunization</subject><subject>Immunocontraception</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other methods of contraception. Sterilization</subject><subject>Parturition</subject><subject>Pregnancy</subject><subject>Rat</subject><subject>Rats</subject><subject>Sexual Maturation</subject><subject>Tissue Extracts - immunology</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotlYfQZmNoovRk8tMJiuR4g0KLrTrkMkkEJlLTWaKfXvTdtClqxzC95_z8yF0juEWA87v3gEwpLwg7BrIDQCDPOUHaIoLLlLIcHGIpr_IBJ2E8AkAXGT8GE0wYULEyBTly2CSziZaDZVKzMpVrto0LiTmu_dK94kKiWuaoe10125_zKp3a3OKjqyqgzkb3xlaPj1-zF_Sxdvz6_xhkWoqcJ-WVlQl2DJnOMfcCkqLONBMcwuUxWa8jKUI2KyguQKV0YwLZSmBgmeaUTpDV_u9K999DSb0MnbTpq5Va7ohSE64YIQWEcz2oPZdCN5YufKuUX4jMcitMLkTJrc2JBC5EyZ5zF2MB4ayMdVfajQUgcsRUEGr2nrVahf-OMYY4YAjd7_nTNSxdsbLoJ1ptamcN7qXVef-qfIDK-iFEA</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Risvanli, Ali</creator><creator>Aydin, Muhterem</creator><creator>Kaygusuzoglu, Erdal</creator><creator>Bulut, Hakan</creator><creator>Apaydin, A.Mukremin</creator><creator>Timurkan, Huseyin</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Use of cauda epididymis extract as immunocontraceptive</title><author>Risvanli, Ali ; Aydin, Muhterem ; Kaygusuzoglu, Erdal ; Bulut, Hakan ; Apaydin, A.Mukremin ; Timurkan, Huseyin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-bf9db0fb641617f933816135c7f0347827b00020f5836a0a53579af320875c433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antibodies - blood</topic><topic>Antigens - immunology</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Cauda epididymis extract</topic><topic>Contraception, Immunologic</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epididymis - immunology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Immunization</topic><topic>Immunocontraception</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other methods of contraception. Sterilization</topic><topic>Parturition</topic><topic>Pregnancy</topic><topic>Rat</topic><topic>Rats</topic><topic>Sexual Maturation</topic><topic>Tissue Extracts - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Risvanli, Ali</creatorcontrib><creatorcontrib>Aydin, Muhterem</creatorcontrib><creatorcontrib>Kaygusuzoglu, Erdal</creatorcontrib><creatorcontrib>Bulut, Hakan</creatorcontrib><creatorcontrib>Apaydin, A.Mukremin</creatorcontrib><creatorcontrib>Timurkan, Huseyin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Risvanli, Ali</au><au>Aydin, Muhterem</au><au>Kaygusuzoglu, Erdal</au><au>Bulut, Hakan</au><au>Apaydin, A.Mukremin</au><au>Timurkan, Huseyin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of cauda epididymis extract as immunocontraceptive</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>66</volume><issue>6</issue><spage>459</spage><epage>462</epage><pages>459-462</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 × 10
9 sperm/mL, while primipara rats received injections of CEE containing 3 × 10
6 sperm/mL up to three times. Animals were tested for the presence and concentration of anti-CEE antibody by enzyme-linked immunosorbent assay (ELISA) and monitored for pregnancy following natural insemination. Results revealed that 38 (92.6%) of the 41 rats were positive for anti-CEE antibodies, regardless of animal type or immunization procedure. However, there was no relation between pregnancy rates and concentration of anti-CEE antibody in rats immunized with CEE. These results indicate that immune response against CEE may not play a major role in contraception in rats.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12499040</pmid><doi>10.1016/S0010-7824(02)00406-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Antibodies - blood Antigens - immunology Biological and medical sciences Birth control Cauda epididymis extract Contraception, Immunologic Enzyme-Linked Immunosorbent Assay Epididymis - immunology Female Gynecology. Andrology. Obstetrics Immunization Immunocontraception Male Medical sciences Other methods of contraception. Sterilization Parturition Pregnancy Rat Rats Sexual Maturation Tissue Extracts - immunology |
| title | Use of cauda epididymis extract as immunocontraceptive |
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