Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists
We optimized a capillary zone electrophoretic method for separation of six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan, irbesartan, losartan potassium, telmisartan, and valsartan. A three-level, full-factorial design was applied to study the effect of the pH and molarity o...
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| Veröffentlicht in: | Journal of Chromatography A 2002-12, Vol.979 (1), p.323-333 |
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| container_title | Journal of Chromatography A |
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| creator | Hillaert, S Van den Bossche, W |
| description | We optimized a capillary zone electrophoretic method for separation of six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan, irbesartan, losartan potassium, telmisartan, and valsartan. A three-level, full-factorial design was applied to study the effect of the pH and molarity of the running buffer on separation. Combination of the studied parameters permitted the separation of the six ARA-IIs, which was best carried out using 60 m
M sodium phosphate buffer (pH 2.5). The same system can also be applied for the quantitative determination of these compounds, but only for the more soluble ones. Some parameters (linearity, precision and accuracy) were validated. |
| doi_str_mv | 10.1016/S0021-9673(02)01247-5 |
| format | Article |
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M sodium phosphate buffer (pH 2.5). The same system can also be applied for the quantitative determination of these compounds, but only for the more soluble ones. Some parameters (linearity, precision and accuracy) were validated.</description><subject>Analysis</subject><subject>Angiotensin II - metabolism</subject><subject>Angiotensin II receptor antagonists</subject><subject>Angiotensin Receptor Antagonists</subject><subject>Biological and medical sciences</subject><subject>Electrophoresis, Capillary - methods</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Angiotensin - metabolism</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1u1DAQgH0AtaXwCCBfQHBIGTuxHZ9QVfGzUqUeCmfL60y6RokdbO9K7QP0ufF2V_TIaTSjb_4-Qt4yuGDA5OdbAM4aLVX7EfgnYLxTjXhBzv6VT8mrnH8DMAWKn5DTSuiey-6MPN4sxc_-wRYfA7VhoDs7-eGQxpFa6uzip8mme_oQA1Kc0JUUl01MWLyjM5ZNHOgYEy0brBPsdJ993vdm3GGyU63d-VgwZB-a1apJ6HAplbeh2LsYfC75NXk52injm2M8J7--ff159aO5vvm-urq8blwnVGl01_ct5yB60AKElcL1dlCdBRjbljnJtZTIVcuURujWnPVacNBKd2vFrWjPyYfD3CXFP1vMxcw-O6z_BYzbbBSvKICsoDiALsWcE45mSX6uFgwDs5dunqSbvV0D3DxJN_sF744LtusZh-euo_EKvD8CNjs7jckG5_Mz1wETUqnKfTlwWHXsPCaTncfgcPBVYDFD9P855S_sfKE-</recordid><startdate>20021206</startdate><enddate>20021206</enddate><creator>Hillaert, S</creator><creator>Van den Bossche, W</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021206</creationdate><title>Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists</title><author>Hillaert, S ; Van den Bossche, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-948832205809505a65c8ad74a00f331c62966e273179e04b21895209794b72a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analysis</topic><topic>Angiotensin II - metabolism</topic><topic>Angiotensin II receptor antagonists</topic><topic>Angiotensin Receptor Antagonists</topic><topic>Biological and medical sciences</topic><topic>Electrophoresis, Capillary - methods</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Angiotensin - metabolism</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillaert, S</creatorcontrib><creatorcontrib>Van den Bossche, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillaert, S</au><au>Van den Bossche, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2002-12-06</date><risdate>2002</risdate><volume>979</volume><issue>1</issue><spage>323</spage><epage>333</epage><pages>323-333</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>We optimized a capillary zone electrophoretic method for separation of six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan, irbesartan, losartan potassium, telmisartan, and valsartan. A three-level, full-factorial design was applied to study the effect of the pH and molarity of the running buffer on separation. Combination of the studied parameters permitted the separation of the six ARA-IIs, which was best carried out using 60 m
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| ispartof | Journal of Chromatography A, 2002-12, Vol.979 (1), p.323-333 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Angiotensin II - metabolism Angiotensin II receptor antagonists Angiotensin Receptor Antagonists Biological and medical sciences Electrophoresis, Capillary - methods General pharmacology Hydrogen-Ion Concentration Medical sciences Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Receptors, Angiotensin - metabolism Reference Standards Reproducibility of Results |
| title | Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists |
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