Self-Administration of Cocaine, Alfentanil, and Nalbuphine Under Progressive-Ratio Schedules: Consumer Demand and Labor Supply Analyses of Relative Reinforcing Effectiveness
Progressive-ratio (PR) schedules of intravenous (IV) drug self-administration are useful for establishing the relationships between reinforcing effectiveness and pharmacological actions of abused drugs. The authors compared the reinforcing effects of the high-efficacy opioid alfentanil, the low-effi...
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| Veröffentlicht in: | Experimental and clinical psychopharmacology 2002-11, Vol.10 (4), p.367-375 |
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| container_title | Experimental and clinical psychopharmacology |
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| creator | Rowlett, James K Rodefer, Joshua S Spealman, Roger D |
| description | Progressive-ratio (PR) schedules of intravenous (IV) drug self-administration are useful for establishing the relationships between reinforcing effectiveness and pharmacological actions of abused drugs. The authors compared the reinforcing effects of the high-efficacy opioid alfentanil, the low-efficacy opioid nalbuphine, and cocaine using a PR schedule of IV drug injection in rhesus monkeys in which the response requirement increased during the experimental session and the initial response requirement (IRR) was varied. Analyses based on either consumer demand or labor supply models of behavioral economics revealed that the relative reinforcing effectiveness of cocaine and alfentanil was greater than that of nalbuphine. These results suggest that PR schedules with varying IRRs can provide meaningful estimates of the relative reinforcing effectiveness of abused drugs. |
| doi_str_mv | 10.1037/1064-1297.10.4.367 |
| format | Article |
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The authors compared the reinforcing effects of the high-efficacy opioid alfentanil, the low-efficacy opioid nalbuphine, and cocaine using a PR schedule of IV drug injection in rhesus monkeys in which the response requirement increased during the experimental session and the initial response requirement (IRR) was varied. Analyses based on either consumer demand or labor supply models of behavioral economics revealed that the relative reinforcing effectiveness of cocaine and alfentanil was greater than that of nalbuphine. These results suggest that PR schedules with varying IRRs can provide meaningful estimates of the relative reinforcing effectiveness of abused drugs.</description><subject>Alfentanil - administration & dosage</subject><subject>Alfentanil - economics</subject><subject>Animal</subject><subject>Animal Models</subject><subject>Animals</subject><subject>Cocaine</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine - economics</subject><subject>Discrimination (Psychology)</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Methods</subject><subject>Drug Administration Schedule - veterinary</subject><subject>Drugs</subject><subject>Female</subject><subject>Injections, Intravenous</subject><subject>Macaca</subject><subject>Male</subject><subject>Monkeys</subject><subject>Nalbuphine - administration & dosage</subject><subject>Nalbuphine - economics</subject><subject>Narcotics - administration & dosage</subject><subject>Narcotics - economics</subject><subject>Opiates</subject><subject>Psychopharmacology</subject><subject>Reaction Time - drug effects</subject><subject>Reinforcement Amounts</subject><subject>Reinforcement Schedule</subject><subject>Reinforcement Schedules</subject><subject>Self Administration - economics</subject><subject>Self Administration - psychology</subject><issn>1064-1297</issn><issn>1936-2293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1r3DAQhkVpaT7_QA_BlJBTvJU0jmQfl6VtCiEJTXILiLE87ip4ZUeyC_n3kbsbAj1JGj3vy_Aw9kXwheCgvwmuilzISqfnoliA0h_YvqhA5VJW8DHd34A9dhDjE-eigEp-ZntCFlUJAPvs8Y66Nl82G-ddHAOOrvdZ32ar3qLzdJ4tu5b8iN515xn6JrvGrp6GdfrLHnxDIbsN_Z9AMbq_lP-e89mdXVMzdRSP2KcWu0jHu_OQPfz4fr-6zK9ufv5aLa9yhIKPuSpriVKgAgIQVkOp084Cm7IgjrVIUF2SVg1UZIVWdVPUreVSJsbKysIhO9v2DqF_niiOZuOipa5DT_0UjZa6gguuE_j1P_Cpn4JPuxmV3JQK_kFyC9nQxxioNUNwGwwvRnAzizezVzN7nSeFSeJT6GTXPNUbat4jO9MJON0COKAZ4ovFMDqbJJlhje89r7dxibA</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Rowlett, James K</creator><creator>Rodefer, Joshua S</creator><creator>Spealman, Roger D</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>200211</creationdate><title>Self-Administration of Cocaine, Alfentanil, and Nalbuphine Under Progressive-Ratio Schedules</title><author>Rowlett, James K ; Rodefer, Joshua S ; Spealman, Roger D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a340t-68b2a21a63e331c73872971ad84e0ab1340b8e76d39ec176bd4bfc02271ac29c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alfentanil - administration & dosage</topic><topic>Alfentanil - economics</topic><topic>Animal</topic><topic>Animal Models</topic><topic>Animals</topic><topic>Cocaine</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine - economics</topic><topic>Discrimination (Psychology)</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Methods</topic><topic>Drug Administration Schedule - veterinary</topic><topic>Drugs</topic><topic>Female</topic><topic>Injections, Intravenous</topic><topic>Macaca</topic><topic>Male</topic><topic>Monkeys</topic><topic>Nalbuphine - administration & dosage</topic><topic>Nalbuphine - economics</topic><topic>Narcotics - administration & dosage</topic><topic>Narcotics - economics</topic><topic>Opiates</topic><topic>Psychopharmacology</topic><topic>Reaction Time - drug effects</topic><topic>Reinforcement Amounts</topic><topic>Reinforcement Schedule</topic><topic>Reinforcement Schedules</topic><topic>Self Administration - economics</topic><topic>Self Administration - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowlett, James K</creatorcontrib><creatorcontrib>Rodefer, Joshua S</creatorcontrib><creatorcontrib>Spealman, Roger D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PsycArticles (via ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowlett, James K</au><au>Rodefer, Joshua S</au><au>Spealman, Roger D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-Administration of Cocaine, Alfentanil, and Nalbuphine Under Progressive-Ratio Schedules: Consumer Demand and Labor Supply Analyses of Relative Reinforcing Effectiveness</atitle><jtitle>Experimental and clinical psychopharmacology</jtitle><addtitle>Exp Clin Psychopharmacol</addtitle><date>2002-11</date><risdate>2002</risdate><volume>10</volume><issue>4</issue><spage>367</spage><epage>375</epage><pages>367-375</pages><issn>1064-1297</issn><eissn>1936-2293</eissn><abstract>Progressive-ratio (PR) schedules of intravenous (IV) drug self-administration are useful for establishing the relationships between reinforcing effectiveness and pharmacological actions of abused drugs. The authors compared the reinforcing effects of the high-efficacy opioid alfentanil, the low-efficacy opioid nalbuphine, and cocaine using a PR schedule of IV drug injection in rhesus monkeys in which the response requirement increased during the experimental session and the initial response requirement (IRR) was varied. Analyses based on either consumer demand or labor supply models of behavioral economics revealed that the relative reinforcing effectiveness of cocaine and alfentanil was greater than that of nalbuphine. These results suggest that PR schedules with varying IRRs can provide meaningful estimates of the relative reinforcing effectiveness of abused drugs.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>12498333</pmid><doi>10.1037/1064-1297.10.4.367</doi><tpages>9</tpages></addata></record> |
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| subjects | Alfentanil - administration & dosage Alfentanil - economics Animal Animal Models Animals Cocaine Cocaine - administration & dosage Cocaine - economics Discrimination (Psychology) Dose-Response Relationship, Drug Drug Administration Methods Drug Administration Schedule - veterinary Drugs Female Injections, Intravenous Macaca Male Monkeys Nalbuphine - administration & dosage Nalbuphine - economics Narcotics - administration & dosage Narcotics - economics Opiates Psychopharmacology Reaction Time - drug effects Reinforcement Amounts Reinforcement Schedule Reinforcement Schedules Self Administration - economics Self Administration - psychology |
| title | Self-Administration of Cocaine, Alfentanil, and Nalbuphine Under Progressive-Ratio Schedules: Consumer Demand and Labor Supply Analyses of Relative Reinforcing Effectiveness |
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