Cyclosporin A Regulates Sodium-Calcium Exchanger (NCX1) Gene Expression in Vitro and Cardiac Hypertrophy in NCX1 Transgenic Mice

: The cardiac‐specific sodium‐calcium exchanger (NCX1) is a GATA‐4 dependent gene that is upregulated during cardiac hypertrophy and heart failure. To date, lack of an appropriate inhibitor of NCX1 and embryonic lethality of NCX1 knockout mice have slowed investigation of the relation between NCX1 u...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-11, Vol.976 (1), p.259-267
Hauptverfasser:	JORDAN, MARIA C., QUEDNAU, BEATE D., ROOS, KENNETH P., ROSS, ROBERT S., PHILIPSON, KENNETH D., NICHOLAS, SUSANNE B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Natriuretic Factor - genetics Calcineurin Inhibitors cardial hypertrophy Cardiomegaly - genetics cyclosporin A Cyclosporine - pharmacology Gene Expression Regulation - drug effects Humans In Vitro Techniques Mice Mice, Transgenic Myosin Heavy Chains - genetics NCX1 Promoter Regions, Genetic Rats Recombinant Proteins - metabolism Sequence Deletion sodium-calcium exchanger Sodium-Calcium Exchanger - genetics transgenic mice
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