Racial Differences in the Frequencies of Scleroderma‐Related Autoantibodies
Objective. To determine demographic differences in scleroderma‐related autoantibodies. Methods. One hundred fifty‐six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti—topoisomerase I (anti—topo I, or Scl‐70), antinucleolar, and anti—U1 RNP autoan...
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| Veröffentlicht in: | Arthritis and rheumatism 1992-02, Vol.35 (2), p.216-218 |
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| container_title | Arthritis and rheumatism |
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| creator | Reveille, John D. Durban, Egon Goldstein, Rose Moreda, Ramon Arnett, Frank C. |
| description | Objective. To determine demographic differences in scleroderma‐related autoantibodies.
Methods. One hundred fifty‐six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti—topoisomerase I (anti—topo I, or Scl‐70), antinucleolar, and anti—U1 RNP autoantibodies.
Results. ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti—topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti—U1 RNP autoantibodies were found.
Conclusion. These data suggest important demographic differences in scleroderma‐associated autoantibodies. |
| doi_str_mv | 10.1002/art.1780350215 |
| format | Article |
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Methods. One hundred fifty‐six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti—topoisomerase I (anti—topo I, or Scl‐70), antinucleolar, and anti—U1 RNP autoantibodies.
Results. ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti—topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti—U1 RNP autoantibodies were found.
Conclusion. These data suggest important demographic differences in scleroderma‐associated autoantibodies.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780350215</identifier><identifier>PMID: 1734910</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>African Continental Ancestry Group - genetics ; Autoantibodies - genetics ; Biological and medical sciences ; European Continental Ancestry Group - genetics ; Hispanic Americans ; Humans ; Medical sciences ; Nuclear Proteins - immunology ; Prospective Studies ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Scleroderma, Systemic - ethnology ; Scleroderma, Systemic - immunology</subject><ispartof>Arthritis and rheumatism, 1992-02, Vol.35 (2), p.216-218</ispartof><rights>Copyright © 1992 American College of Rheumatology</rights><rights>1992 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4005-34a1a278fa3963c261141f9f09f69f70aa8f46c4cc8db125278f75231e06cdd23</citedby><cites>FETCH-LOGICAL-c4005-34a1a278fa3963c261141f9f09f69f70aa8f46c4cc8db125278f75231e06cdd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780350215$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780350215$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5117665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1734910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reveille, John D.</creatorcontrib><creatorcontrib>Durban, Egon</creatorcontrib><creatorcontrib>Goldstein, Rose</creatorcontrib><creatorcontrib>Moreda, Ramon</creatorcontrib><creatorcontrib>Arnett, Frank C.</creatorcontrib><title>Racial Differences in the Frequencies of Scleroderma‐Related Autoantibodies</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective. To determine demographic differences in scleroderma‐related autoantibodies.
Methods. One hundred fifty‐six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti—topoisomerase I (anti—topo I, or Scl‐70), antinucleolar, and anti—U1 RNP autoantibodies.
Results. ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti—topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti—U1 RNP autoantibodies were found.
Conclusion. These data suggest important demographic differences in scleroderma‐associated autoantibodies.</description><subject>African Continental Ancestry Group - genetics</subject><subject>Autoantibodies - genetics</subject><subject>Biological and medical sciences</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nuclear Proteins - immunology</subject><subject>Prospective Studies</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Scleroderma, Systemic - ethnology</subject><subject>Scleroderma, Systemic - immunology</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWj-u3oQ9iLetM8km2RyL36AIVc_LNJvgyraryRbpzZ_gb_SXmNKi3jwNmXnmzfAwdogwRAB-SqEfoi5BSOAoN9gAJTc5oMBNNgCAIhfS4A7bjfElPbmQYpttoxaFQRiwuzHZhtrsvPHeBTezLmbNLOufXXYZ3Ns8dZrU6nz2YFsXutqFKX19fI5dS72rs9G872jWN5OuTtw-2_LURnewrnvs6fLi8ew6v72_ujkb3ea2AJC5KAiJ69KTMEpYrhAL9MaD8cp4DUSlL5QtrC3rCXK5RLXkAh0oW9dc7LGTVe5r6NKNsa-mTbSubWnmunmsNNeGF6X5F0TFVQlaJnC4Am3oYgzOV6-hmVJYVAjVUnSVRFe_otPC0Tp5Ppm6-hdfmU3z4_WcoqXWB0om4w8mEbVSyxizwt6b1i3--bQajR__nPANd46WXw</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>Reveille, John D.</creator><creator>Durban, Egon</creator><creator>Goldstein, Rose</creator><creator>Moreda, Ramon</creator><creator>Arnett, Frank C.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199202</creationdate><title>Racial Differences in the Frequencies of Scleroderma‐Related Autoantibodies</title><author>Reveille, John D. ; Durban, Egon ; Goldstein, Rose ; Moreda, Ramon ; Arnett, Frank C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4005-34a1a278fa3963c261141f9f09f69f70aa8f46c4cc8db125278f75231e06cdd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>African Continental Ancestry Group - genetics</topic><topic>Autoantibodies - genetics</topic><topic>Biological and medical sciences</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nuclear Proteins - immunology</topic><topic>Prospective Studies</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Scleroderma, Systemic - ethnology</topic><topic>Scleroderma, Systemic - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Reveille, John D.</creatorcontrib><creatorcontrib>Durban, Egon</creatorcontrib><creatorcontrib>Goldstein, Rose</creatorcontrib><creatorcontrib>Moreda, Ramon</creatorcontrib><creatorcontrib>Arnett, Frank C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reveille, John D.</au><au>Durban, Egon</au><au>Goldstein, Rose</au><au>Moreda, Ramon</au><au>Arnett, Frank C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Racial Differences in the Frequencies of Scleroderma‐Related Autoantibodies</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1992-02</date><risdate>1992</risdate><volume>35</volume><issue>2</issue><spage>216</spage><epage>218</epage><pages>216-218</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective. To determine demographic differences in scleroderma‐related autoantibodies.
Methods. One hundred fifty‐six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti—topoisomerase I (anti—topo I, or Scl‐70), antinucleolar, and anti—U1 RNP autoantibodies.
Results. ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti—topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti—U1 RNP autoantibodies were found.
Conclusion. These data suggest important demographic differences in scleroderma‐associated autoantibodies.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>1734910</pmid><doi>10.1002/art.1780350215</doi><tpages>3</tpages></addata></record> |
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| ispartof | Arthritis and rheumatism, 1992-02, Vol.35 (2), p.216-218 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | African Continental Ancestry Group - genetics Autoantibodies - genetics Biological and medical sciences European Continental Ancestry Group - genetics Hispanic Americans Humans Medical sciences Nuclear Proteins - immunology Prospective Studies Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - ethnology Scleroderma, Systemic - immunology |
| title | Racial Differences in the Frequencies of Scleroderma‐Related Autoantibodies |
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