Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases

The site of action of cysteine‐proteinases (CPs) and matrix metalloproteinases (MMPs) in the degradation of bone collagen by osteoclasts was investigated by evaluating the effects of the CP‐inhibitor trans‐epoxy‐succinyl‐L‐leucylamido (4‐guanidino)‐butane (E‐64) and the MMP‐inhibitor N‐(3‐N‐benzylox...

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Veröffentlicht in:	Journal of cellular physiology 1992-02, Vol.150 (2), p.221-231
Hauptverfasser:	Everts, Vincent, Delaissé, Jean-Marie, Korper, Wolf, Niehof, Anneke, Vaes, Gilbert, Beertsen, Wouter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Matrix - metabolism Bone Resorption Calcitonin - pharmacology Calcium - metabolism Collagen - metabolism Cysteine Proteinase Inhibitors - pharmacology Glucuronidase - metabolism In Vitro Techniques Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - metabolism Mice Osteoclasts - metabolism Parathyroid Hormone - pharmacology Space life sciences
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