Characterization of Acetylcholine-Induced Membrane Hyperpolarization in Endothelial Cells

The characteristics of the hyperpolarization response to acetylcholine (ACh) in endothelial cells from the guinea pig coronary artery were studied by microelectrode recording technique. ACh (30 nM to 3 μM) induced membrane hyperpolarization in a dose-dependent manner. The sustenance of the response...

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Veröffentlicht in:	Circulation research 1992-02, Vol.70 (2), p.257-263
Hauptverfasser:	Chen, Guifa, Cheung, Donald W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Arginine - analogs & derivatives Biological and medical sciences Blood vessels and receptors Calcium - pharmacology Electrophysiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Guinea Pigs Male Potassium - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - physiology Vertebrates: cardiovascular system
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