Voltage-addressable on/off microvalves for high-pressure microchip separations
We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid contr...
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| Veröffentlicht in: | Journal of Chromatography A 2002-12, Vol.979 (1), p.147-154 |
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| container_end_page | 154 |
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| container_title | Journal of Chromatography A |
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| creator | Kirby, Brian J Shepodd, Timothy J Hasselbrink, Ernest F |
| description | We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid control elements, which are opened and closed by electrokinetic pressures. The glass substrates and crosslinked polymer monoliths operate in water–acetonitrile mixtures and have been shown to hold off pressures as high as 350 bar (5000 p.s.i.). Open/closed flow ratios of 10
4 to 10
6 have been demonstrated over the pressure range 1.5–70 bar (20–1000 p.s.i.), and the pressure–leak relationship shows the potential for valving control of flow through packed or monolithic chromatography columns. We expect that this valve platform will enable multiplexing of multiple chromatographic separations on single microchips. |
| doi_str_mv | 10.1016/S0021-9673(02)01453-X |
| format | Article |
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4 to 10
6 have been demonstrated over the pressure range 1.5–70 bar (20–1000 p.s.i.), and the pressure–leak relationship shows the potential for valving control of flow through packed or monolithic chromatography columns. We expect that this valve platform will enable multiplexing of multiple chromatographic separations on single microchips.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(02)01453-X</identifier><identifier>PMID: 12498243</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analytical chemistry ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, High Pressure Liquid - instrumentation ; Equipment Design ; Exact sciences and technology ; Other chromatographic methods ; Semiconductors</subject><ispartof>Journal of Chromatography A, 2002-12, Vol.979 (1), p.147-154</ispartof><rights>2002</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e7ec01b2f57af2cc0361d0e2dd61b203625c30de0f4dbc5c01fa9701013343353</citedby><cites>FETCH-LOGICAL-c391t-e7ec01b2f57af2cc0361d0e2dd61b203625c30de0f4dbc5c01fa9701013343353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0021-9673(02)01453-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14015656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12498243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirby, Brian J</creatorcontrib><creatorcontrib>Shepodd, Timothy J</creatorcontrib><creatorcontrib>Hasselbrink, Ernest F</creatorcontrib><title>Voltage-addressable on/off microvalves for high-pressure microchip separations</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid control elements, which are opened and closed by electrokinetic pressures. The glass substrates and crosslinked polymer monoliths operate in water–acetonitrile mixtures and have been shown to hold off pressures as high as 350 bar (5000 p.s.i.). Open/closed flow ratios of 10
4 to 10
6 have been demonstrated over the pressure range 1.5–70 bar (20–1000 p.s.i.), and the pressure–leak relationship shows the potential for valving control of flow through packed or monolithic chromatography columns. We expect that this valve platform will enable multiplexing of multiple chromatographic separations on single microchips.</description><subject>Analytical chemistry</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Equipment Design</subject><subject>Exact sciences and technology</subject><subject>Other chromatographic methods</subject><subject>Semiconductors</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhn0AQVkeAZQLCA6hYztLc0IIsUkIDiziZjn2uDVK42CnlXh73KaCIyfLM994fn-EHFG4oECL8QsAo2lVlPwM2DnQLOfpxxYZ_ZZ3yV4InwC0hJLtkF3KsmrCMj4iT--u6eUUU6m1xxBk3WDi2rEzJplb5d1SNksMiXE-mdnpLO1W1MLj0FUz2yUBO-llb10bDsi2kU3Aw825T95ub16v79PH57uH66vHVPGK9imWqIDWzOSlNEwp4AXVgEzrIlbjjeWKg0Ywma5VHlkjqxLiZznPOM_5Pjkd3u28-1pg6MXcBoVNI1t0iyBKVk6qSUEjmA9gDBuCRyM6b-fSfwsKYiVPrOWJlSUBTKzliY84d7xZsKjnqP-mNuYicLIBZFCyMV62yoY_LgOaF3kRucuBw6hjadGLoCy2CrX1qHqhnf0nyg-nEo52</recordid><startdate>20021206</startdate><enddate>20021206</enddate><creator>Kirby, Brian J</creator><creator>Shepodd, Timothy J</creator><creator>Hasselbrink, Ernest F</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021206</creationdate><title>Voltage-addressable on/off microvalves for high-pressure microchip separations</title><author>Kirby, Brian J ; Shepodd, Timothy J ; Hasselbrink, Ernest F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e7ec01b2f57af2cc0361d0e2dd61b203625c30de0f4dbc5c01fa9701013343353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analytical chemistry</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Equipment Design</topic><topic>Exact sciences and technology</topic><topic>Other chromatographic methods</topic><topic>Semiconductors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirby, Brian J</creatorcontrib><creatorcontrib>Shepodd, Timothy J</creatorcontrib><creatorcontrib>Hasselbrink, Ernest F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirby, Brian J</au><au>Shepodd, Timothy J</au><au>Hasselbrink, Ernest F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Voltage-addressable on/off microvalves for high-pressure microchip separations</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2002-12-06</date><risdate>2002</risdate><volume>979</volume><issue>1</issue><spage>147</spage><epage>154</epage><pages>147-154</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid control elements, which are opened and closed by electrokinetic pressures. The glass substrates and crosslinked polymer monoliths operate in water–acetonitrile mixtures and have been shown to hold off pressures as high as 350 bar (5000 p.s.i.). Open/closed flow ratios of 10
4 to 10
6 have been demonstrated over the pressure range 1.5–70 bar (20–1000 p.s.i.), and the pressure–leak relationship shows the potential for valving control of flow through packed or monolithic chromatography columns. We expect that this valve platform will enable multiplexing of multiple chromatographic separations on single microchips.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12498243</pmid><doi>10.1016/S0021-9673(02)01453-X</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - instrumentation Equipment Design Exact sciences and technology Other chromatographic methods Semiconductors |
| title | Voltage-addressable on/off microvalves for high-pressure microchip separations |
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