SPARC is a key schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis

Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studies suggest that Schwann cells influence NB t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-12, Vol.62 (24), p.7357-7363
Hauptverfasser:	CHLENSKI, Alexandre, SHUQING LIU, COHN, Susan L, CRAWFORD, Susan E, VOLPERT, Olga V, DEVRIES, George H, EVANGELISTA, Amy, QIWEI YANG, SALWEN, Helen R, FARRER, Robert, BRAY, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenesis Inhibitors - biosynthesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - physiology Angiogenesis Inhibitors - secretion Animals Antineoplastic agents Biological and medical sciences Cell Differentiation - physiology Cell Division - physiology Cell Movement - drug effects Chemotherapy Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Female Humans Medical sciences Mice Mice, Nude Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neuroblastoma - blood supply Neuroblastoma - metabolism Neuroblastoma - pathology Osteonectin - biosynthesis Osteonectin - pharmacology Osteonectin - physiology Osteonectin - secretion Pharmacology. Drug treatments Schwann Cells - metabolism Schwann Cells - secretion Xenograft Model Antitumor Assays
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