ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature

Physiological differences between tumor and normal vasculature provide a target for drug discovery. In particular, the immature nature of tumor vasculature may render it intrinsically sensitive to disruption by agents affecting the endothelial cell cytoskeleton, including tubulin-binding agents. In...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-12, Vol.62 (24), p.7247-7253
Hauptverfasser:	DAVIS, Peter D, DOUGHERTY, Graeme J, HILL, Sally A, BLAKEY, David C, GALBRAITH, Susan M, TOZER, Gillian M, HOLDER, Angela L, NAYLOR, Matthew A, NOLAN, John, STRATFORD, Michael R. L, CHAPLIN, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - drug therapy Adenocarcinoma - pathology Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - pharmacokinetics Angiogenesis Inhibitors - pharmacology Animals Antineoplastic agents Biological and medical sciences Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Cattle Cell Survival - drug effects Chemotherapy Colchicine - analogs & derivatives Colchicine - pharmacology Dose-Response Relationship, Drug Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Female Humans Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mice, Inbred CBA Mice, SCID Necrosis Neoplasms, Experimental - blood supply Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neovascularization, Pathologic - drug therapy Organophosphorus Compounds - chemical synthesis Organophosphorus Compounds - pharmacokinetics Organophosphorus Compounds - pharmacology Pharmacology. Drug treatments Pharyngeal Neoplasms - blood supply Pharyngeal Neoplasms - drug therapy Pharyngeal Neoplasms - pathology Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Prodrugs - pharmacology Protein Binding Tubulin - metabolism Xenograft Model Antitumor Assays
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