Signal transduction by G proteins in cardiac tissues
The role of G proteins in mediating the responses of the heart to circulating catecholamines and to the influences of the autonomic nervous system is of special interest to cardiologists. It is evident that G proteins are essential links in the cascade of biochemical events that ensure when neurotra...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1992-02, Vol.85 (2), p.420-433 |
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| container_end_page | 433 |
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| container_issue | 2 |
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| container_title | Circulation (New York, N.Y.) |
| container_volume | 85 |
| creator | FLEMING, J. W WISLER, P. L WATANABE, A. M |
| description | The role of G proteins in mediating the responses of the heart to circulating catecholamines and to the influences of the autonomic nervous system is of special interest to cardiologists. It is evident that G proteins are essential links in the cascade of biochemical events that ensure when neurotransmitters and hormones interact with receptors on myocardial cells. It is likely [corrected] that dysfunction of G proteins plays a role in cardiovascular pathophysiology. With current methodologies, especially molecular biological and recombinant DNA techniques, and with transgenic animal models that can relate physiological function and specific gene dosage, some cardiovascular diseases may be traced to G protein-related defects. |
| doi_str_mv | 10.1161/01.cir.85.2.420 |
| format | Article |
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With current methodologies, especially molecular biological and recombinant DNA techniques, and with transgenic animal models that can relate physiological function and specific gene dosage, some cardiovascular diseases may be traced to G protein-related defects.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.85.2.420</identifier><identifier>PMID: 1735141</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Cardiovascular Diseases - metabolism ; Fundamental and applied biological sciences. 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With current methodologies, especially molecular biological and recombinant DNA techniques, and with transgenic animal models that can relate physiological function and specific gene dosage, some cardiovascular diseases may be traced to G protein-related defects.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GTP-Binding Proteins - analysis</subject><subject>GTP-Binding Proteins - chemistry</subject><subject>GTP-Binding Proteins - physiology</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>Heart Conduction System - anatomy & histology</subject><subject>Humans</subject><subject>Signal Transduction - physiology</subject><subject>Structure-Activity Relationship</subject><subject>Vertebrates: cardiovascular system</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo67p69iT0IN7azSSZtjnKouvCguDHOaRJKpFuuybtwf_eyC56Gmbeb2Yej5BroAVACUsKhfGhqLFghWD0hMwBmcgFcnlK5pRSmVecsXNyEeNnakte4YzMoOIIAuZEvPqPXnfZGHQf7WRGP_RZ852ts30YRuf7mPk-MzpYr002-hgnFy_JWau76K6OdUHeHx_eVk_59nm9Wd1vcyMkH_NaQi0dxbKseCso6JKhZpIJbSFNZSNqLqBsnIVGW2mRIiZ_ViJIbBvkC3J3uJu8fKW_o9r5aFzX6d4NU1QVq-oaqzqBywNowhBjcK3aB7_T4VsBVb85KQpqtXlRNSqmUk5p4-Z4emp2zv7zh2CSfnvUdTS6a1M8xsc_DBmVJUj-AzkCbeI</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>FLEMING, J. 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| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1992-02, Vol.85 (2), p.420-433 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Cardiovascular Diseases - metabolism Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - analysis GTP-Binding Proteins - chemistry GTP-Binding Proteins - physiology Heart Heart - physiology Heart Conduction System - anatomy & histology Humans Signal Transduction - physiology Structure-Activity Relationship Vertebrates: cardiovascular system |
| title | Signal transduction by G proteins in cardiac tissues |
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