Cisplatin induced alterations in oriented fibers of DNA studied by atomic force microscopy

Oriented fibers of DNA, prepared by the wet spin method, were imaged by atomic force microscopy. It was found that an oriented fiber's substructure is an array of assemblages of DNA. For native DNA, the assemblages exhibit a characteristic width of 76 nm, a thickness of 20 nm, and appear to car...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-01, Vol.182 (1), p.201-207
1. Verfasser:	Rampino, Nicholas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cisplatin - pharmacology DNA - drug effects DNA - ultrastructure Microscopy - methods
Online-Zugang:	Volltext
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