Cisplatin induced alterations in oriented fibers of DNA studied by atomic force microscopy

Oriented fibers of DNA, prepared by the wet spin method, were imaged by atomic force microscopy. It was found that an oriented fiber's substructure is an array of assemblages of DNA. For native DNA, the assemblages exhibit a characteristic width of 76 nm, a thickness of 20 nm, and appear to car...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-01, Vol.182 (1), p.201-207
1. Verfasser:	Rampino, Nicholas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cisplatin - pharmacology DNA - drug effects DNA - ultrastructure Microscopy - methods
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creator	Rampino, Nicholas J.
description	Oriented fibers of DNA, prepared by the wet spin method, were imaged by atomic force microscopy. It was found that an oriented fiber's substructure is an array of assemblages of DNA. For native DNA, the assemblages exhibit a characteristic width of 76 nm, a thickness of 20 nm, and appear to carry a right handed twist. Treatment with the anticancer drug cisplatin prior to wet spinning induces geometric irregularities, in the form of kinks and width distortions, into the assemblages of DNA.
doi_str_mv	10.1016/S0006-291X(05)80131-7
format	Article
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subjects	Cisplatin - pharmacology DNA - drug effects DNA - ultrastructure Microscopy - methods
title	Cisplatin induced alterations in oriented fibers of DNA studied by atomic force microscopy
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