Comparison of cefotaxime with ceftriaxone given intramuscularly 12-hourly for community-acquired pneumonia
Cefotaxime 1 g intramuscularly (i.m.) 12-hourly was compared with ceftriaxone 1 g i.m. 12-hourly in adult patients requiring hospitalization with uncomplicated community-acquired pneumonia. Fifty-two patients were enrolled and two were subsequently withdrawn, leaving 50 patients who completed the st...
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Veröffentlicht in: | Diagnostic microbiology and infectious disease 1992, Vol.15 (1), p.81-84 |
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creator | Dansey, Roger D. Jacka, Peter J. Strachan, Simon A. Hay, Malcolm |
description | Cefotaxime 1 g intramuscularly (i.m.) 12-hourly was compared with ceftriaxone 1 g i.m. 12-hourly in adult patients requiring hospitalization with uncomplicated community-acquired pneumonia. Fifty-two patients were enrolled and two were subsequently withdrawn, leaving 50 patients who completed the study; 23 received cefotaxime and 27 received ceftriaxone. Clinical cure was achieved in 49 of the 50 patients (98%). One treatment failure occurred in a patient who received ceftriaxone. The only significant pathogen isolated from the pretreatment sputum cultures was
Streptococcus pneumoniae (50%). All isolates were sensitive to both drugs. Cefotaxime 1 g i.m. 12-hourly was as effective as ceftriaxone in the treatment of patients with uncomplicated community-acquired pneumonia requiring hospital admission. |
doi_str_mv | 10.1016/0732-8893(92)90060-7 |
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Streptococcus pneumoniae (50%). All isolates were sensitive to both drugs. Cefotaxime 1 g i.m. 12-hourly was as effective as ceftriaxone in the treatment of patients with uncomplicated community-acquired pneumonia requiring hospital admission.</description><subject>Adult</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cefotaxime - administration & dosage</subject><subject>Cefotaxime - therapeutic use</subject><subject>Ceftriaxone - administration & dosage</subject><subject>Ceftriaxone - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumonia - drug therapy</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKtvCPwApB4TKIWDH8dq-VEIrvqRKXOBsOeMJdRXbWzsu3X9Pwq7KjdPM6H1mNHoIecXoe0bZ9gOVvGuV0vxSd-80pVvayidkw5TULaWSPiWbR-Q5OS_lllLW6Z6ekTMmOWVKbcjtLoW9zb6k2KSxARzTbB98wOa3n2_Wec7ePqSIzS9_j7Hxcc421AJ1snk6NKxrb1JduzHlBlIINfr50Fq4qz6ja_YRa0jR2xfk2Wingi9P9YL8_Pzpx-5re_39y7fdx-sWuNrO7QgwMuGQuZ4JDgycVE51SjsnNZNiYLTrxUD7gQ9CgkUrrBIgNUUBDDW_IG-Pd_c53VUsswm-AE6TjZhqMbKTSm5lv4D9EYScSsk4mn32weaDYdSsis3qz6z-jO7MX8VGLmuvT_frEND9Wzo6XfI3p9wWsNOYbQRfHjHBuO4FX7CrI4aLi3uP2RTwGAHdog1m45L__x9_AEfBmhU</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Dansey, Roger D.</creator><creator>Jacka, Peter J.</creator><creator>Strachan, Simon A.</creator><creator>Hay, Malcolm</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Comparison of cefotaxime with ceftriaxone given intramuscularly 12-hourly for community-acquired pneumonia</title><author>Dansey, Roger D. ; Jacka, Peter J. ; Strachan, Simon A. ; Hay, Malcolm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-fccf15de1d4153c1cd78d8289dd79175b10245b04b3b57caea5a85c790e5c1e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cefotaxime - administration & dosage</topic><topic>Cefotaxime - therapeutic use</topic><topic>Ceftriaxone - administration & dosage</topic><topic>Ceftriaxone - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Pneumonia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dansey, Roger D.</creatorcontrib><creatorcontrib>Jacka, Peter J.</creatorcontrib><creatorcontrib>Strachan, Simon A.</creatorcontrib><creatorcontrib>Hay, Malcolm</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dansey, Roger D.</au><au>Jacka, Peter J.</au><au>Strachan, Simon A.</au><au>Hay, Malcolm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of cefotaxime with ceftriaxone given intramuscularly 12-hourly for community-acquired pneumonia</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>1992</date><risdate>1992</risdate><volume>15</volume><issue>1</issue><spage>81</spage><epage>84</epage><pages>81-84</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><abstract>Cefotaxime 1 g intramuscularly (i.m.) 12-hourly was compared with ceftriaxone 1 g i.m. 12-hourly in adult patients requiring hospitalization with uncomplicated community-acquired pneumonia. Fifty-two patients were enrolled and two were subsequently withdrawn, leaving 50 patients who completed the study; 23 received cefotaxime and 27 received ceftriaxone. Clinical cure was achieved in 49 of the 50 patients (98%). One treatment failure occurred in a patient who received ceftriaxone. The only significant pathogen isolated from the pretreatment sputum cultures was
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subjects | Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefotaxime - administration & dosage Cefotaxime - therapeutic use Ceftriaxone - administration & dosage Ceftriaxone - therapeutic use Drug Administration Schedule Humans Injections, Intramuscular Male Medical sciences Middle Aged Pharmacology. Drug treatments Pneumonia - drug therapy |
title | Comparison of cefotaxime with ceftriaxone given intramuscularly 12-hourly for community-acquired pneumonia |
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