Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias

The synthesis of 8-hydroxy and 8-methoxy analogues of some substituted 5-aminoimidazoacridinones (4) is described. The synthesis was carried out by a three-step sequence from the corresponding 1-chloro-4-nitro-9(10H)-acridinone precursors (1). The annulation of the imidazolo ring onto the aminoacrid...

Ausführliche Beschreibung