Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens

Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens

The effects of acute IP administration (0.5, 1.0 or 2.0 g/kg) and local perfusion (25, 50 or 100 mM) of ethanol on the extracellular concentrations of dopamine (DA), serotonin (5-HT) and their metabolites in the nucleus accumbens (ACC) of the rat were studied with in vivo microdialysis coupled with...

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Veröffentlicht in:Alcohol (Fayetteville, N.Y.) N.Y.), 1992, Vol.9 (1), p.17-22
Hauptverfasser: Yoshimoto, K., McBride, W.J., Lumeng, L., Li, T.-K.
Format: Artikel
Sprache:eng
Schlagworte:
3,4-Dihydroxyphenylacetic Acid - metabolism
5-HT 3 receptors
Alcohol
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Chromatography, High Pressure Liquid
Dialysis
Dopamine
Dopamine - metabolism
Ethanol - pharmacology
Homovanillic Acid - metabolism
Hydroxyindoleacetic Acid - metabolism
In vivo release
Kinetics
Male
Medical sciences
Microdialysis
Nucleus accumbens
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Rats
Rats, Inbred Strains
Serotonin
Serotonin - metabolism
Toxicology
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Zusammenfassung:The effects of acute IP administration (0.5, 1.0 or 2.0 g/kg) and local perfusion (25, 50 or 100 mM) of ethanol on the extracellular concentrations of dopamine (DA), serotonin (5-HT) and their metabolites in the nucleus accumbens (ACC) of the rat were studied with in vivo microdialysis coupled with a small-bore HPLC electrochemical detection procedure. The IP administration of 1.0 and 2.0 g/kg ethanol significantly ( p
ISSN:0741-8329
1873-6823
DOI:10.1016/0741-8329(92)90004-T