Two-step generation of spirocyclic dipeptides from linear peptide ethyl ester precursors

Linear tri- and tetrapeptide precursors of 2,5-piperazinedione were prepared and their conversion to spirocycic dipeptides was studied. In Vitro, using purified peptidase enzymes, the spirocyclic dipeptides (SpDp) were generated from the precursors by a two-step mechanism consisting in the proteolyt...

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Veröffentlicht in:	Life sciences (1973) 1992, Vol.50 (3), p.187-193
Hauptverfasser:	KASAFIREK, E, RYBAK, M, KREJCI, I, STURC, A, KREPELA, E, SEDO, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibiotics, Antineoplastic - chemistry Biological and medical sciences Chromatography, Thin Layer dipeptides Fibrinolysin - biosynthesis General pharmacology Kallikreins - biosynthesis Medical sciences Memory - drug effects Mice Mice, Inbred C57BL Molecular Sequence Data Oligopeptides - chemistry Oligopeptides - pharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Piperazines - chemistry Spiro Compounds - administration & dosage Spiro Compounds - blood Spiro Compounds - chemical synthesis
Online-Zugang:	Volltext
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